Serum 25-hydroxyvitamin D, bone turnover markers and bone mineral density in postmenopausal women with hip fractures

Fan, Jixing; Li, Ning; Gong, Xiaofeng; He, Li

doi:10.1016/j.cca.2017.12.015

Cited by 23 publications

(30 citation statements)

References 35 publications

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“…The results revealed that 25(OH)D was negatively correlated with β-CTX and N-MID, which suggests that 25(OH)D levels could affect the levels of relevant BTMs. [24]. In addition, the present study also found that 25(OH)D was positively correlated with total hip and femoral neck BMD, which is consistent with previous studies.…”

Section: Discussionsupporting

confidence: 93%

“…[31] The present study demonstrated that of 25(OH)D levels in the case group were signi cantly lower than those in the control group, which suggests that 25(OH)D level is also associated with hip fractures in elderly women. [21,24,32,33] In addition, the AUC for 25(OH)D was signi cantly higher than that of femoral neck BMD and height, indicating that 25(OH)D may be a more dependable and effective indicator in the assessment of hip fractures in elderly Chinese women. In our present study, we selected participants with age paired to eliminate the impact of age on each indicator.…”

Section: Discussionmentioning

confidence: 98%

“…Controversy, however, persists about whether BTMs are associated with hip fractures in the elderly. [13,[24][25][26][27][28][29][30] The reasons for this controversy may be attributed to study design (i.e., prospective or retrospective), sample size, differences in metabolic indices selected, and whether a su cient number of confounding factors of bone metabolism have been taken into account. As a blood-based biochemical index, BTMs can be affected by many factors including age, sex, drug use, metabolic disease, circadian rhythm, and exercise level, among others.…”

Section: Discussionmentioning

confidence: 99%

“…[26] However, our result was inconsistent with that of Fan et.al. [24] One possible reason for the differences may be the sampling time. In our patients, blood samples were all obtained on the next morning at fasting status after fractures, while theirs were collected within one week after admission in the study by Fan.…”

Section: Discussionmentioning

confidence: 99%

“…In our patients, blood samples were all obtained on the next morning at fasting status after fractures, while theirs were collected within one week after admission in the study by Fan. [24] As time progresses, the impact of fracture on bone turnover is increasingly obvious. [19] Therefore, the concentration of BTMs may be severely affected by fracture status, which would lead to an acceleration in the bone turnover process, resulting in an increase in β-CTX and N-MID levels.…”

Section: Discussionmentioning

confidence: 99%

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Analysis of combined indicators for risk of osteoporotic hip fractures in elderly women

Zhao¹,

Shi²,

Jiang³

et al. 2020

Preprint

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Background Hip fractures in the elderly population has become a global issue due to its high morbidity and mortality. Although an increasing number of researchers are devoting attention to identify risk factors in attempts to reduce the incidence of hip fractures in the elderly, only few studies have investigated combined indicators in elderly hip fractures. The objective of the present study was to compare the accuracy of combined independent risk factors in assessing the risk of hip fractures in elderly women. Methods Ninety elderly females who sustained hip fractures and 110 female outpatients who fulfilled the inclusion criteria were included in our cross-sectional study. Bone mineral density (BMD), Beta-carboxy terminal telopeptide(β-CTX), N-terminal/mid region (N-MID), and 25(OH)D levels were analyzed. A novel evaluation model was established to evaluate combined indicators in assessing hip fractures in elderly women. Results Compared with the control group, taller height, higher levels of β-CTX, and lower levels of total hip BMD, femoral neck BMD, and 25(OH)D were found in the facture group. After adjustment for confounding factors, logistic regression analysis revealed that 25(OH)D, femoral neck BMD and height remained risk factors for hip fractures in elderly women. Then a model including independent risk factors was established. DeLong test showed the area under the ROC(AUC) of 25(OH)D was significantly greater than that for femoral neck BMD (p < 0.01) and height (p < 0.01). AUC of model including 25(OH)D and height was significantly greater than that of other combinations (p < 0.01). Conclusion 25(OH)D, femoral neck BMD and height were associated with the occurrence of hip fractures in elderly women even after adjustment for confounding factors, and model including 25(OH)D and height could provide better associated power than other combinations in the assessment of elderly hip fractures. β-CTX and N-MID were not independent risk factors for hip fractures in elderly women.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Analysis of combined indicators for risk of osteoporotic hip fractures in elderly women

Zhao¹,

Shi²,

Jiang³

et al. 2020

Preprint

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Bone Turnover Markers Are Not Associated With Hip Fracture Risk: A Case-Control Study in the Women's Health Initiative

Crandall

Vasan

LaCroix

et al. 2018

Journal of Bone and Mineral Research

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Current guidelines recommend that serum C-terminal telopeptide of type I collagen (CTX) and serum procollagen type 1 aminoterminal propeptide (PINP), measured by standardized assays, be used as reference markers in observational and interventional studies. However, there are limited data to determine whether serum CTX and PINP are associated with hip fracture risk among postmenopausal women. We determined the associations of serum CTX and serum PINP with hip fracture risk among postmenopausal women aged 50 to 79 years at baseline. We performed a prospective case-control study (400 cases, 400 controls) nested in the Women's Health Initiative Observational Study, which enrolled participants at 40 US clinical centers. Cases were women with incident hip fracture not taking osteoporosis medication; hip fractures were confirmed using medical records. Untreated controls were matched by age, race/ethnicity, and date of blood sampling. Serum CTX and serum PINP were analyzed on 12-hour fasting blood samples. The main outcome measure was incident hip fracture risk (mean follow-up 7.13 years). After adjustment for body mass index, smoking, frequency of falls, history of fracture, calcium and vitamin D intake, and other relevant covariates, neither serum CTX level nor serum PINP level was statistically significantly associated with hip fracture risk (CTX p = 0.22, PINP p = 0.53). Our results do not support the utility of serum CTX level or PINP level to predict hip fracture risk in women in this age group. These results will inform future guidelines regarding the potential utility of these markers in fracture prediction. © 2018 American Society for Bone and Mineral Research.

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Fracture risk prediction in old Chinese people—a narrative review

Su,

Zhou,

Kwok

2023

Arch Osteoporos

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Serum 25-hydroxyvitamin D, bone turnover markers and bone mineral density in postmenopausal women with hip fractures

Cited by 23 publications

References 35 publications

Analysis of combined indicators for risk of osteoporotic hip fractures in elderly women

Analysis of combined indicators for risk of osteoporotic hip fractures in elderly women

Bone Turnover Markers Are Not Associated With Hip Fracture Risk: A Case-Control Study in the Women's Health Initiative

Fracture risk prediction in old Chinese people—a narrative review

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