Serum 25-hydroxyvitamin D but not dietary vitamin D intake is associated with hemoglobin in women of reproductive age in rural northern Vietnam

Michalski, Ellen S.; Nguyen, Phuong Hong; González-Casanova, Inés; Nguyen, Son; Martorell, Reynaldo; Tangpricha, Vin; Ramakrishnan, Usha

doi:10.1016/j.jcte.2017.05.001

Cited by 8 publications

(7 citation statements)

References 36 publications

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“…Furthermore, it was difficult to replace vitamin D content of food based on the food composition databases from other countries due to the vast difference of food (containing vitamin D) among Chinese people, especially commercial food and fortified food. In general, the main source of vitamin D is the synthesis mediated by UVB radiation and dietary vitamin D intake may not be a good proxy for vitamin D status [71,72]. Thus, we were more inclined to use serum 25-hydroxyvitamin D to assess vitamin D status.…”

Section: Limitationsmentioning

confidence: 99%

Dietary Micronutrients Intake Status among Chinese Elderly People Living at Home: Data from CNNHS 2010–2012

et al. 2019

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The aim of this study was to examine the status of usual dietary micronutrient intakes among Chinese elderly living at home. The data was based on China National Nutrition and Health Survey (CNNHS) 2010–2012. We analyzed data from the participants aged 60-year-old and more (n = 16,612) living at home, who provided dietary data on three days 24 h dietary survey combining with the household weighing method. The means and distribution percentiles for usual intakes of dietary micronutrients were estimated using the Multiple Source Method (MSM). The prevalence of inadequacy for the selected micronutrients was expressed using the proportion of individuals with usual intakes below the Estimated Average Requirement (EAR). For vitamin E, sodium and potassium, the means and the distribution of intakes were compared to the Adequate Intake (AI) level. Usual dietary intakes of most micronutrients were inadequate in the participants, especially folate, calcium, vitamin B6 and vitamin B2, with the prevalence of inadequacy more than 90%. However, dietary sodium intake was extremely high with an average usual intake of 4702 mg/day. The usual dietary intakes of all selected micronutrients in old males were higher than females, and the prevalence of inadequacy of most micronutrients was higher in old women (p < 0.01). The subjects aged 60–74 years tended to have higher usual dietary micronutrient intakes and lower prevalence of inadequate micronutrients than those aged 75 years and over (p < 0.01). Higher usual dietary intakes and lower prevalence of inadequacy of most micronutrients were found in the elderly living in the southern region (p < 0.01). The average usual intakes of most micronutrients declined with socioeconomic status. The prevalence of inadequate vitamin A, B2, C, calcium and selenium below EAR increased with socioeconomic status (p < 0.01, p for trend < 0.01). Thus, essential micronutrients insufficient intake is a public health concern among Chinese community-dwelling old population, especially the females, older people, the elderly in undeveloped areas or living in northern regions. Nutrition education and appropriate approach should be undertaken to address these problems.

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Section: Limitationsmentioning

confidence: 99%

Dietary Micronutrients Intake Status among Chinese Elderly People Living at Home: Data from CNNHS 2010–2012

et al. 2019

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“…Vitamin D deficiency and anemia frequently coexist [1,2,3,4,5]. A number of mechanisms could explain this association [1] and recent data provide evidence for a direct role of vitamin D in the suppression of hepcidin: the primary regulator of systemic iron homeostasis.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Vitamin D Supplementation on Hepcidin, Iron Status, and Inflammation in Pregnant Women in the United Kingdom

et al. 2019

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Iron and vitamin D deficiencies are common during pregnancy. Our aim was to identify whether antenatal vitamin D3 supplementation affects iron status (via hepcidin suppression) and/or inflammation. Using a subset of the UK multicenter Maternal Vitamin D Osteoporosis Study (MAVIDOS)—a double-blinded, randomized, placebo-controlled trial (ISRCTN82927713; EudraCT2007-001716-23)—we performed a secondary laboratory analysis. Women with blood samples from early and late pregnancy (vitamin D3 (1000 IU/day from ~14 weeks gestation n = 93; placebo n = 102) who gave birth in the springtime (March–May) were selected as we anticipated seeing the greatest treatment group difference in change in 25-hydroxyvitamin D (25OHD) concentration. Outcomes were hepcidin, ferritin, C-reactive protein, and α1-acid glycoprotein concentration in late pregnancy (25OHD concentration was measured previously). By late pregnancy, 25OHD concentration increased by 17 nmol/L in the vitamin D3 group and decreased by 11 nmol/L in the placebo group; hepcidin, ferritin, and inflammatory markers decreased but no treatment group differences were seen. In late pregnancy, positive relationships between 25OHD and hepcidin and 25OHD and ferritin in the placebo group were observed but not in the treatment group (group × 25OHD interaction, p < 0.02). Vitamin D3 supplementation had no effect on hepcidin, ferritin, or inflammatory status suggesting no adjunctive value of vitamin D3 in reducing rates of antenatal iron deficiency.

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“…Multiple clinical studies detected a similar association where Michalski et al (32) found low vitamin D status may be linked to reduced HC in pregnant women. Also, Yuan et al (33) reported that maternal serum 25OH-VD < 50.0 nmol/L may be a risk factor for gestational anemia, and it should be monitored for the high-risk pregnant women.…”

Section: Results:-mentioning

confidence: 64%

Can Vitamin D Supplemental Therapy Improve Pregnancy-Associated Anemia? An Interventional Prospective Clinical Trial.

MD¹,

MD²

2018

IJAR

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Objectives: To evaluate impact of vitamin D supplemental therapy (VD-ST) and iron ST (IST) on hemoglobin concentration (HC) in pregnant women. Patients & Methods: 187 women pregnant were clinically evaluated and gave blood samples at 1 st trimester for estimation of HC and serum 25OH-VD, ferritin concentration (FC), hepcidin (HPC) and interleukin-6 (IL-6). Women were categorized according to the levels of estimated parameters into control and study groups AD. Women of groups A and C received VD-ST alone, group B received IST alone and group D received both ST. At delivery, HC, extent of change and frequency of pregnancy-associated anemia (PAA) were determined. Results: At 1 st trimester, 71.7% women were anemic and 38.5% had hypoferremia, 77% had VD deficiency (VDD) and 59.4% had both VDD and PAA. Serum HPC and IL-6 levels in anemic women especially those had VDD were significantly higher than control women. At delivery, 35% of control women developed PAA and mean HC was significantly lower than 1 st trimester HC with a median deficit of 4.72 gm/dl (IQR: 2.8-6.4) among studied population. Frequency of anemic women in groups B-D was decreased at delivery by 21.7%, 30.8% and 30.6%, respectively. Statistical analyses defined high serum HPC and IL-6 levels at 1 st trimester as specific early predictors for PAA development, but early institution of ST especially VD-ST is one of the best significant predictors for improved HC at time of delivery. Conclusion: VDD, hypoferremia, higher HPC and IL-6 levels constitute a vicious circle entrapping pregnant women and inducing iron deficiency anemia at delivery. Early institution of VD-ST and IST can burst this circle and induce improvement of HC up to normal range in about 30% of women presented by PAA. Thus, early estimation of HC and serum VD can be used as a guide for early institution of ST.

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Serum 25-hydroxyvitamin D but not dietary vitamin D intake is associated with hemoglobin in women of reproductive age in rural northern Vietnam

Cited by 8 publications

References 36 publications

Dietary Micronutrients Intake Status among Chinese Elderly People Living at Home: Data from CNNHS 2010–2012

Dietary Micronutrients Intake Status among Chinese Elderly People Living at Home: Data from CNNHS 2010–2012

The Effect of Vitamin D Supplementation on Hepcidin, Iron Status, and Inflammation in Pregnant Women in the United Kingdom

Can Vitamin D Supplemental Therapy Improve Pregnancy-Associated Anemia? An Interventional Prospective Clinical Trial.

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