Serum 25-hydroxyvitamin D concentration and its determinants in the very old: the Newcastle 85+ Study

Hill, Thomas; Granic, Antoneta; Davies, Karen; Collerton, Joanna; Martin-Ruiz, Carmen; Siervo, Mario; Mathers, John C.; Adamson, Ashley; Francis, Roger M.; Pearce, Simon H. S.; Razvi, Salman; Kirkwood, Thomas B. L.; Jagger, Carol

doi:10.1007/s00198-015-3366-9

Cited by 30 publications

(34 citation statements)

References 34 publications

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“…We are aware of only one study of adults aged ≥80 from Belgium that found no association between 25(OH)D concentration and several measures of muscle performance in cross-sectional analyses, but interpretation of these findings may be complicated by the high prevalence of severe vitamin D deficiency (<25 nmol/L) in this cohort, especially in winter [48]. Because of pronounced seasonal variations in 25(OH)D in our study (51% had concentrations <30 nmol/L in spring, and 23% in autumn) [33], we used season-specific quartiles—a preferred method to adjust for the cyclical nature of 25(OH)D [38]. We also repeated the analysis for GS using pre-defined cut-offs [5,10], and did not find greater benefits for muscle strength in participants with 25(OH)D ≥75nmo/L.…”

Section: Discussionmentioning

confidence: 66%

“…The intake of vitamin D supplements and medication was an important determinant of 25(OH)D status in this cohort [22,23,33], especially in women, and was mainly related to diagnosis of osteoporosis [35]. However, similar acceleration in the rate of GS decline was observed in all participants and in those who were not supplemented with vitamin D, suggesting that supplementation did not attenuate the findings and that other sources of vitamin D (diet and sun exposure) may be more relevant for musculoskeletal health.…”

Section: Discussionmentioning

confidence: 99%

“…Only a few have included the very old (aged ≥ 85) [24,26,27,29], despite this being the age group at greatest risk of muscle mass and strength loss [30,31], functional decline [32], and, perhaps, low 25(OH)D status [33]. …”

Section: Introductionmentioning

confidence: 99%

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Vitamin D Status, Muscle Strength and Physical Performance Decline in Very Old Adults: A Prospective Study

et al. 2017

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Mixed reports exist about the role of 25-hydroxyvitamin D (25(OH)D) in muscle ageing and there are few prospective studies involving the very old (aged ≥ 85) who are at highest risk of low 25(OH)D, loss of muscle mass and strength, and physical performance decline. In the Newcastle 85+ Study (n = 845), we aimed to determine the association between 25(OH)D season-specific quartiles (hereafter SQ1–SQ4), grip strength (GS) and physical performance decline (Timed Up-and-Go Test, TUG) over 5 years using mixed models. In the time-only models with linear and quadratic slopes, SQ1 and SQ4 of 25(OH)D were associated with weaker GS initially in men (SQ1: β (SE) = −2.56 (0.96); SQ4: −2.16 (1.06)) and women (SQ1: −1.10 (0.52); SQ4: −1.28 (0.50)) (all p ≤ 0.04). In the fully adjusted models, only men in SQ1 had a significant annual decline in GS of 1.41 kg which accelerated over time (−0.40 (0.1)), (both p ≤ 0.003) compared with those in combined middle quartiles. Only women in SQ1 and SQ4 of 25(OH)D had worse TUG times initially, but the rate of TUG decline was not affected. Low baseline 25(OH)D may contribute to muscle strength decline in the very old and particularly in men.

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Section: Discussionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 99%

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Vitamin D Status, Muscle Strength and Physical Performance Decline in Very Old Adults: A Prospective Study

et al. 2017

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“…No/irregular use of supplements was a strong common predictor of subclinical 25OHD and folate and vitamin B 12 deficiencies. Prior studies in older adults have found that supplement use is a major predictor of vitamin D status [14,17] and is linked to higher vitamin B 12 and folate levels [54,55]. Although 44.7% of KORA-Age participants used supplements containing vitamins or minerals [36], only around 10% took supplements containing vitamin D, folate and vitamin B 12 , respectively.…”

Section: No/irregular Use Of Supplementsmentioning

confidence: 99%

Prevalence and predictors of subclinical micronutrient deficiency in German older adults: Results from the population-based KORA-Age study

Conzade

Köenig

Heier

et al. 2018

Revue d'Épidémiologie et de Santé Publique

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Subclinical micronutrient deficiency in older adults is associated with chronic age-related diseases and adverse functional outcomes. In Germany, the older population is at risk of insufficient micronutrient intake, but representative studies on micronutrient status in old and very old adults are scarce. This study's objectives were to estimate the prevalence of subclinical vitamin D, folate, vitamin B 12 and iron deficiencies among older adults, aged 65 to 93, from the KORA-Age study in Augsburg, Germany (n = 1079), and to examine associated predictors, using multiple logistic regression. Serum concentrations of 25-hydroxyvitamin D (25OHD), folate, vitamin B 12 , and iron were analyzed. The prevalence of subclinical vitamin D and vitamin B 12 deficiencies were high, with 52.0% and 27.3% of individuals having low 25OHD (<50 nmol/L) and low vitamin B 12 concentrations (<221 pmol/L), respectively. Furthermore, 11.0% had low iron (men <11.6 µmol/L, women <9.0 µmol/L) and 8.7% had low folate levels (<13.6 nmol/L). Common predictors associated with subclinical micronutrient deficiency included very old age, physical inactivity, frailty and no/irregular use of supplements. Subclinical micronutrient deficiency is a public health concern among KORA-Age participants, especially for vitamins D and B 12 . The predictors identified provide further rationale for screening high-risk subgroups and developing targeted public health interventions to tackle prevailing micronutrient inadequacies among older adults.

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“…It reflects vitamin D produced cutaneously and that obtained from food and supplements, and has a fairly long circulating half-life of 15 days [19]. Despite the fact that many studies have reported factors associated with serum 25(OH)D concentrations such as age, body mass index, ethnicity, skin pigmentation, latitude, altitude and season [20], to our knowledge, data on serum 25-hydroxyvitamin D [25(OH)D] and its independent factors in very elderly (aged 80 years or more) males remain to be fully explored [21]. and detected the serum levels of bone turnover markers (BTMS), biochemical parameters and sex steroid hormones in 903 very elderly Chinese males.…”

Section: Introductionmentioning

confidence: 99%

Independent factors associated with serum levels of 25- Hydroxyvitamin D in very elderly Chinese males

Bian¹,

Shou²,

Wang³

et al. 2017

Rheumatol Orthop Med

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Background: Vitamin D deficiency has been associated with a wide variety of chronic diseases and even all-cause mortality. Data on serum 25-hydroxyvitamin D [25(OH)D] and its independent factors in very elderly (aged 80 years or more) males remain to be fully explored. This study was designed to identify independent factors associated with the serum levels of 25(OH)D in very elderly Chinese males.

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Serum 25-hydroxyvitamin D concentration and its determinants in the very old: the Newcastle 85+ Study

Cited by 30 publications

References 34 publications

Vitamin D Status, Muscle Strength and Physical Performance Decline in Very Old Adults: A Prospective Study

Vitamin D Status, Muscle Strength and Physical Performance Decline in Very Old Adults: A Prospective Study

Prevalence and predictors of subclinical micronutrient deficiency in German older adults: Results from the population-based KORA-Age study

Independent factors associated with serum levels of 25- Hydroxyvitamin D in very elderly Chinese males

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