Serum 25-hydroxyvitamin D concentrations are inversely associated with body adiposity measurements but the association with bone mass is non-linear in postmenopausal women

Ganji, Vijay; Shi, Zumin; Alshami, Hanadi; Ajina, Sarah; Albakri, Shayma; Jasim, Zahra

doi:10.1016/j.jsbmb.2021.105923

Cited by 4 publications

(2 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Results revealed that the prevalence of increased waist circumference (WC), insulin resistance, and vitamin D deficiency was high in postmenopausal women. Recently, a study reported an inverse relationship between serum vitamin D concentrations and body adiposity markers such as BMI ( p < 0.0005), WC ( p < 0.044), fat mass ( p < 0.003), android fat ( p < 0.009), and gynecoid fat ( p < 0.001) in postmenopausal Qatari women [ 38 ]. Using the data from the Korean National Health and Nutrition Examination Survey, investigators have reported that MetSyn markers and the MetSyn risk were statistically different in postmenopausal women between those who are vitamin D deficient and sufficient.…”

Section: Results Of Studies On Hypovitaminosis D and Metsyn In Postme...mentioning

confidence: 99%

Hypovitaminosis D and Metabolic Syndrome in Postmenopausal Women

2022

View full text Add to dashboard Cite

Metabolic syndrome (MetSyn) is a precursor for several cardiometabolic diseases. The prevalence of MetSyn is higher in postmenopausal women compared to premenopausal women. The role of vitamin D in postmenopausal women is not clearly understood. Hypovitaminosis is more prevalent in postmenopausal women compared to premenopausal women. For this review, Pubmed, Cochrane, SCOPUS, Embase, and Google Scholar databases were searched up to August 2022. Findings from one randomized controlled trial (RCT) and ten cross-sectional studies were included in this review. Several cross-sectional studies (8 out of 10 reviewed) unequivocally demonstrated an inverse association between serum vitamin D concentrations and MetSyn. However, RCTs are severely lacking in the effect of vitamin D intake on the biomarkers of MetSyn and the prevalence of MetSyn. Therefore, caution should be used in recommending mega doses of vitamin D supplements for postmenopausal women because of the potential adverse effects associated with this vitamer.

show abstract

Section: Results Of Studies On Hypovitaminosis D and Metsyn In Postme...mentioning

confidence: 99%

Hypovitaminosis D and Metabolic Syndrome in Postmenopausal Women

2022

View full text Add to dashboard Cite

show abstract

“…Estrogen also increases norepinephrine activity in the brain, perhaps by decreasing reuptake and degradation due to inhibition of MAO and catechol-O-methyltransferase 23). Decrease in estrogen is also related to a decrease in serum vitamin D. During menopause, women experience thinner skin and lower ability to produce vitamin D, in addition to reduced intestinal absorption of vitamin D and decreased vitamin D hydroxylation in the liver and kidneys 24). Vitamin D reportedly reduces depressive symptoms in postmenopausal women by controlling the concentration of the neurotransmitter, serotonin, which increases the production of sex…”

mentioning

confidence: 99%

The Difference between Serum Vitamin D Level and Depressive Symptoms in Korean Adult Women before and after Menopause: The 5th (2010–2012) Korean National Health and Nutrition Examination Survey

Lee¹,

Choi²,

Bae³

et al. 2023

Korean J Health Promot

View full text Add to dashboard Cite

Background: The relationship between serum vitamin D levels and depressive symptoms has not been consistent in previous studies in Korean women. Menopause is known to be related to depression and vitamin D.Methods: This study included 11,573 women from the 5th Korea National Health and Nutrition Examination Survey. Serum vitamin D levels were divided into four groups according to quartiles, and depressive symptoms were collected into two groups. Multiple logistic regression analysis was conducted in each group of women before and after menopause.Results: Compared with the highest vitamin D group, the lowest vitamin D group did not show significant differences in all females (odds ratio [OR], 0.98; 95% confidence interval [CI], 0.78-1.22). In premenopausal women, compared to the first quartile, ORs were presented in the second quartile (OR, 0.75; 95% CI, 0.53-1.07), third quartile (OR, 0.70; 95% CI, 0.49-1.00) and fourth quartile (OR, 0.62; 95% CI, 0.43-0.92) respectively, and they were statistically significant (<i>P</i>=0.016). In postmenopausal women, compared to the first quartile, ORs were presented in the second quartile (OR, 1.06; 95% CI, 0.78-1.44), third quartile (OR, 1.18; 95% CI, 0.87-1.61), and fourth quartile (OR, 1.27; 95% CI, 0.98-1.66) respectively; however, they were not statistically significant (<i>P</i>=0.057).Conclusions: Depression symptoms increased with a decrease in serum vitamin D in premenopausal women, but the opposite trend was observed in postmenopausal women. In future studies, if the relationship between blood vitamin D and depression is studied, the menopausal status of women can be used as an important criterion.

show abstract