Serum 25-hydroxyvitamin D concentrations in dogs with osteosarcoma do not differ from those of age- and weight-matched control dogs

Willcox, Jennifer L.; Hammett‐Stabler, Catherine A.; Hauck, Marlene

doi:10.1016/j.tvjl.2016.10.005

Cited by 8 publications

(9 citation statements)

References 8 publications

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“…Others reported lower plasma 25(OH)D concentrations in dogs with several cancer types compared to healthy dogs . However, this finding could not be confirmed in dogs with osteosarcoma . These studies did not include blood ICa concentrations as covariates in the statistical analysis, and direct comparisons between results cannot be made.…”

Section: Discussionmentioning

confidence: 92%

“…[14][15][16][17] However, this finding could not be confirmed in dogs with osteosarcoma. 29 These studies did not include blood ICa concentrations as covariates in the statistical analysis, and direct comparisons between results cannot be made. Although an effect of plasma ICa status on plasma 25(OH)D concentrations makes biological sense (circulating ICa tightly regulates 1,25(OH) 2 D production 30 which may affect 25(OH)D concentrations), no other studies examining correlations between ICa and 25(OH) D concentrations in healthy dogs or in dogs with disease are available.…”

Section: Discussionmentioning

confidence: 99%

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Influence of Various Factors on Circulating 25(OH) Vitamin D Concentrations in Dogs with Cancer and Healthy Dogs

Weidner

Woods

Conlon

et al. 2017

Veterinary Internal Medicne

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BackgroundLow blood 25‐hydroxyvitamin D (25(OH)D) concentrations have been associated with cancer in dogs. Little research has examined what other factors may affect 25(OH)D concentrations.Objectives(1) To determine whether the presence of cancer (lymphoma, osteosarcoma, or mast cell tumor [MCT]) in dogs is associated with plasma 25(OH)D concentrations and (2) identify other factors related to plasma 25(OH)D concentrations in dogs.AnimalsDogs newly diagnosed with osteosarcoma (n = 21), lymphoma (n = 27), and MCT (n = 21) presented to a tertiary referral oncology center, and healthy, client‐owned dogs (n = 23).MethodsAn observational study design was used. Dietary vitamin D intake, sex, age, body condition score (BCS), muscle condition score (MCS), and plasma concentrations of 25(OH)D, 24,25‐dihydroxyvitamin D (24,25(OH)2D) (a marker of CYP24A1 activity), as well as ionized calcium (ICa), parathyroid hormone, and parathyroid hormone‐related protein concentrations were measured. An analysis of covariance was used to model plasma 25(OH)D concentrations.ResultsCancer type (P = 0.004), plasma 24,25(OH)2D concentrations (P < 0.001), and plasma ICa concentrations (P = 0.047) had significant effects on plasma 25(OH)D concentrations. Effects of age, sex, body weight, BCS, MCS, and plasma PTH concentrations were not identified. A significant interaction between ICa and cancer was found (P = 0.005). Plasma 25(OH)D concentrations increased as ICa concentrations increased in dogs with cancer, whereas plasma 25(OH)D concentrations decreased as ICa concentrations increased in healthy dogs.Conclusions and Clinical ImportanceResults support a relationship between cancer and altered vitamin D metabolism in dogs, mediated by plasma ICa concentrations. The CYP24A1 activity and plasma ICa should be measured in studies examining plasma 25(OH)D concentrations in dogs.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Influence of Various Factors on Circulating 25(OH) Vitamin D Concentrations in Dogs with Cancer and Healthy Dogs

Weidner

Woods

Conlon

et al. 2017

Veterinary Internal Medicne

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“…Wakshlag et al (2011) evaluated the relationship between serum concentrations of 25(OH)D and mastocytoma in Labrador Retrievers.In total, 33 animals affected by this disease were evaluated and compared with a control group that was composed of 54 healthy animals, and lower serum concentrations 25(OH)D were observed in dogs with mastocytoma.In another study conducted bySelting et al (2016), the 25(OH) D serum concentrations from a group of healthy dogs (control group; n = 282) were compared to 25(OH)D serum concentrations from a group of dogs with splenic malignancies (all-cancer group; n = 40) and with another group of dogs with benign neoplasms (benign group; n = 22). In contrast,Willcox, Hammett-Stabler, and Hauck (2016) found no difference in serum concentrations of 25(OH)D in 20 dogs affected by osteosarcoma, compared with a control group matched for age and body weight.Studies have demonstrated in vitro antineoplastic effects of calcitriol for various types of canine tumours, including osteosarcoma(Barroga, Kadosawa, Okumura, & Fujinaga, 1999), squamous cell carcinoma(Kunakornsawat et al, 2001), prostatic epithelial tumour(Kunakornsawat et al, 2004), anal sac adenocarcinoma(Kunakornsawat et al, 2002), mammary gland cancer(Rassnick et al, 2008) and mastocytoma(Malone et al, 2010). The control group presented higher 25(OH)D serum concentrations when compared to all other groups.…”

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confidence: 59%

“…In addition, an increased relative risk (RR) for cancer was observed as serum 25(OH)D levels decreased; therefore, the RR of cancer for 25(OH)D below 40 ng/ml of all-cancer group and of HAS group were 3.9 and 4.1, respectively, compared with that of the control group. In contrast,Willcox, Hammett-Stabler, and Hauck (2016) found no difference in serum concentrations of 25(OH)D in 20 dogs affected by osteosarcoma, compared with a control group matched for age and body weight.Studies have demonstrated in vitro antineoplastic effects of calcitriol for various types of canine tumours, including osteosarcoma(Barroga, Kadosawa, Okumura, & Fujinaga, 1999), squamous cell carcinoma(Kunakornsawat et al, 2001), prostatic epithelial tumour(Kunakornsawat et al, 2004), anal sac adenocarcinoma(Kunakornsawat et al, 2002), mammary gland cancer(Rassnick et al, 2008) and mastocytoma(Malone et al, 2010). These findings reinforce the hypothesis that low concentrations of vitamin D may increase the risk of developing cancer.…”

mentioning

confidence: 59%

Vitamin D metabolism in dogs and cats and its relation to diseases not associated with bone metabolism

Zafalon

Risolia

Pedrinelli

et al. 2019

Animal Physiology Nutrition

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Due to the presence of receptors in the cells of numerous body tissues, vitamin D is associated with several physiological functions that go beyond calcium and phosphorus homoeostasis and control of bone metabolism in the body. In humans, several studies have associated lower vitamin D concentrations with numerous diseases, such as cancer, heart disease, autoimmune diseases and infectious diseases, and also with an increase in the total mortality rate of the population. Recently, this nutrient started to gain importance in veterinary medicine, and several articles have shown a correlation between low vitamin D status and diseases unrelated to bone metabolism. The present review aims to highlight the recent publications that investigated this relationship, bringing the evidence that exists so far in dogs and cats. K E Y W O R D S1,25(OH)2D, 25(OH)D, calcidiol, calcitriol, cholecalciferol, hypovitaminosis D

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“…No reference range exists for 3-epi-25(OH)D3 in humans, therefore data from a systemic review which reported ranges from several studies was used (see Bailey et al (2013) [79]). The number of studies included to provide data for each of the veterinary species are as follows: (A) dogs n = 8 [80][81][82][83][84][85][86][87], cats n = 1 [85], horses n = 1 [88], sheep n = 4 [30,[89][90][91], cattle n = 2 [92,93], pigs n = 1 [94], poultry n = 2 [95,96] and nonhuman primates n = 2 [97,98]; (B) dogs n = 2 [81,85] and cats n = 1 [85]; and C. dogs n = 1 [83]. nd = no data available for the metabolites measured by LC-MS/MS in that species.…”

Section: Comparative Differences In Vitamin D Metabolismmentioning

confidence: 99%

Vitamin D Metabolism and Profiling in Veterinary Species

2020

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The demand for vitamin D analysis in veterinary species is increasing with the growing knowledge of the extra-skeletal role vitamin D plays in health and disease. The circulating 25-hydroxyvitamin-D (25(OH)D) metabolite is used to assess vitamin D status, and the benefits of analysing other metabolites in the complex vitamin D pathway are being discovered in humans. Profiling of the vitamin D pathway by liquid chromatography tandem mass spectrometry (LC-MS/MS) facilitates simultaneous analysis of multiple metabolites in a single sample and over wide dynamic ranges, and this method is now considered the gold-standard for quantifying vitamin D metabolites. However, very few studies report using LC-MS/MS for the analysis of vitamin D metabolites in veterinary species. Given the complexity of the vitamin D pathway and the similarities in the roles of vitamin D in health and disease between humans and companion animals, there is a clear need to establish a comprehensive, reliable method for veterinary analysis that is comparable to that used in human clinical practice. In this review, we highlight the differences in vitamin D metabolism between veterinary species and the benefits of measuring vitamin D metabolites beyond 25(OH)D. Finally, we discuss the analytical challenges in profiling vitamin D in veterinary species with a focus on LC-MS/MS methods.

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Serum 25-hydroxyvitamin D concentrations in dogs with osteosarcoma do not differ from those of age- and weight-matched control dogs

Cited by 8 publications

References 8 publications

Influence of Various Factors on Circulating 25(OH) Vitamin D Concentrations in Dogs with Cancer and Healthy Dogs

Influence of Various Factors on Circulating 25(OH) Vitamin D Concentrations in Dogs with Cancer and Healthy Dogs

Vitamin D metabolism in dogs and cats and its relation to diseases not associated with bone metabolism

Vitamin D Metabolism and Profiling in Veterinary Species

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