Serum 25-hydroxyvitamin D is associated with obesity and metabolic parameters in US children

Zhi, Fachao; Xu, Cheng; Shu, Yaqin; Xie, Zongyun; Lu, Changgui; Mo, Xuming

doi:10.1017/s1368980019001137

Cited by 33 publications

(36 citation statements)

References 55 publications

(58 reference statements)

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“…Here, we found vitamin D insufficiency was associated with abnormal TC only in girls. The gender difference may be due to reduced intake of vitamin D and the lack of outdoor activity 9. A Mendelian randomization study48 has provided the evidence that single nucleotide polymorphisms causing variations in 25(OH)D can lead to a genetically increased remnant lipoprotein-cholesterol.…”

Section: Discussionmentioning

confidence: 99%

“…The cellular effects of vitamin D which are mediated by ubiquitous vitamin D receptor were found in the heart, kidneys, brain and muscles 4. It has been demonstrated that vitamin D deficiency may be associated with several cardiovascular-related conditions such as metabolic syndrome, diabetes mellitus, hypertension and coronary artery disease 5–9. In adults, longitudinal associations between serum 25-hydroxyvitamin D (25(OH)D) concentration and cardiometabolic risk factors were observed in a number of cohort studies 10–12.…”

Section: Introductionmentioning

confidence: 99%

“…Muscle is also a storage site for vitamin D metabolites by taking it up and releasing it into the circulation 19. Low 25(OH)D concentration, which represents the sum of 25-hydroxyergocalciferol and 25-hydroxycholecalciferol, was reported to be associated with cardiovascular risk factors in children 5 6 8 9 20 21. However, few studies have controlled for effect of body composition on the association between vitamin D deficiency and cardiovascular risk.…”

Section: Introductionmentioning

confidence: 99%

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Adequate 25-hydroxyvitamin D levels are inversely associated with various cardiometabolic risk factors in Chinese children, especially obese children

Xiao

Dong

et al. 2020

BMJ Open Diab Res Care

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ObjectiveVitamin D deficiency has recently evolved as a major public health issue worldwide. But the relationship between vitamin D and cardiovascular health in children remains unclear. Accordingly, we aimed to examine the associations between 25-hydroxyvitamin D (25(OH)D) concentrations and cardiometabolic risk factors, and to assess the possible effect modification of obesity on the associations in a Chinese pediatric population.Research design and methodsA cross-sectional sample of 6091 children aged 6–18 years was obtained using a cluster sampling method. The 25(OH)D concentrations, and metabolic risk factors, including waist to height ratio, blood pressure, blood lipids, fasting blood glucose (FBG), and insulin were measured. Adjusted ORs and multiplicative or additive interaction were calculated to assess the associations and effect modification, respectively.ResultsTriglycerides, FBG, insulin, and homeostasis model assessment of insulin resistance were inversely associated with 25(OH)D concentrations (p<0.05) in both sexes. The OR of hyperglycemia among individuals with insufficient vitamin D was higher than those with adequate vitamin D after adjusting for covariates (OR: 1.47; 95% CI 1.26 to 1.70). Moreover, girls with insufficient vitamin D had significantly higher odds for hypertension and high total cholesterol than those with adequate vitamin D, which was not observed in boys. Thirty-two percent (95% CI 14% to 51%) of the increased odds of hyperglycemia can be explained by the interaction between insufficient vitamin D and obesity.ConclusionsVitamin D insufficiency is associated with increased odds of various cardiometabolic risk factors in Chinese children and has a synergistic effect on hyperglycemia with obesity.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Adequate 25-hydroxyvitamin D levels are inversely associated with various cardiometabolic risk factors in Chinese children, especially obese children

Xiao

Dong

et al. 2020

BMJ Open Diab Res Care

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“…The chronic inflammation that accompanied obesity develop to insulin resistance by the increased production of inflammatory cytokines from immune cell such as macrophages and adipocytes (Peterson et al, 2014). Similar to a study in China, it was stated that children with vitamin D deficiency had 4.15 times more at risk of developing insulin resistance than children without vitamin D deficiency (Fu et al, 2020). On the contrary, a study on 301 children aged 11-18 years in Turkey showed no significant relationship between insulin resistance and vitamin D status.…”

Section: Discussionmentioning

confidence: 77%

Relationship Between Vitamin D Deficiency And Insulin Resistance In Obese Children

Juliaty¹,

Gabrilasari²,

Daud³

et al. 2020

GJHS

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INTRODUCTION: Obesity represents the major risk factor for development of insulin resistance during childhood and adolescents. In obesity, adipose tissue release free fatty acids, various hormones, and cytokines, resulting in insulin resistance. This study aimed to establish the correlation between vitamin D deficiency and the incidence of insulin resistance in obese children. DESIGN AND METHOD: This analytical cross-sectional study was arranged from December 2019 - February 2020 included 96 students aged 11 - 17 years old from junior and senior high school who met the criteria for obesity in Makassar. The study subjects were parted into two groups, obese children with vitamin D deficiency (levels of 25-hydroxyvitamin D ≤ 20 ng/ml) and obese children without vitamin D deficiency group (levels of 25-hydroxyvitamin D > 20 ng/ml). Data were analyzed using univariate and bivariate analysis. RESULTS: The frequency of insulin resistance in obese children with vitamin D deficiency was 28 (54.9%), while obese children without vitamin D deficiency was 10 (22.2%). Based on statistical analysis, the frequency of the occurrence of insulin resistance in vitamin D deficiency obese children was higher than in obese children without vitamin D deficiency with OR = 4.261 (95% CI 1.744 – 10.411), p = 0.001. CONCLUSION: The risk of insulin resistance in obese children with vitamin D deficiency is 4.261 times higher than obese children without vitamin D deficiency.

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“…For more details about potential confounders in the NHANES, please refer to our previous studies [18,19]. In our analyses, we considered the following covariates: information on age (years), sex (male or female), race/ethnicity (non-Hispanic white, non-Hispanic black, Mexican American, or others), education levels (< high school, ≥high school), family poverty-income ratio (PIR), history of physiciandiagnosed diabetes (yes/no).…”

Section: Covariatesmentioning

confidence: 99%

Plasma glucose levels in the association between serum trans-β-carotene and obesity among children and adolescents

zang

Liu

Zheng

et al. 2020

Preprint

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Background Results on the association between trans-β-carotene and obesity are less clear and little is known about how their relationship may be affected by plasma glucose levels.The present study aimed to evaluate the relationships between trans-β-carotene and obesity and to investigate whether plasma glucose levels had a modifying effect on these relationships. Methods Children aged 6-18 years were selected from the National Health and Nutrition Examination Survey(NHANES) (2001–2006) (n =8030). The serum trans-β-carotene levels were divided into tertiles, and their associations with obesity were evaluated using multivariable-adjusted linear regression models adjusted for potential confounding factors. The interaction effects between trans-β-carotene levels and plasma glucose levels on obesity were further evaluated. Results In the fully adjusted model, using serum trans-β-carotene as natural log-transformed continuous variable, the negative association between trans-β-carotene level and obesity were confirmed. In addition, plasma glucose levels significantly modified the inverse association between trans-β-carotene and obesity (p value for interaction: 0.09). A stronger association of trans-β-carotene levels with obesity was found in higher plasma glucose levels (more than100 mg/dl) than in lower plasma glucose levels. Further, a non-linear relationship was detected between trans-β-carotene and obesity in participants with higher plasma glucose levels, with an inflection point of 2.7 (trans-β-carotene =14.88 ug/dl). The effect sizes and confidence intervals for the left and right sides of the inflection point were 0.10 (0.00 to 0.2) and 6.7 (0.1 to 348.2), respectively. Conclusion Our findings indicate that the association between trans-β-carotene concentration and obesity is stronger in individuals with higher plasma glucose population than in those with lower plasma glucose levels.

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Serum 25-hydroxyvitamin D is associated with obesity and metabolic parameters in US children

Cited by 33 publications

References 55 publications

Adequate 25-hydroxyvitamin D levels are inversely associated with various cardiometabolic risk factors in Chinese children, especially obese children

Adequate 25-hydroxyvitamin D levels are inversely associated with various cardiometabolic risk factors in Chinese children, especially obese children

Relationship Between Vitamin D Deficiency And Insulin Resistance In Obese Children

Plasma glucose levels in the association between serum trans-β-carotene and obesity among children and adolescents

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