Serum 25-hydroxyvitamin D levels and peripheral neuropathy in patients with type 2 diabetes: a systematic review and meta-analysis

Lv, Wenshan; Zhao, Wenjuan; Gong, S. L.; Fang, Dongdong; Wang, B.; Fu, Zhengju; Yan, Shushan; Wang, Y. G.

doi:10.1007/s40618-014-0210-6

Cited by 81 publications

(50 citation statements)

References 29 publications

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“…Furthermore, a meta-analysis in type 2 diabetes (n ¼ 1484) confirmed a significant correlation between serum vitamin D 3 levels and the risk for DPN. 187 An open-label, prospective study conducted in Pakistan found a single IM-administered dose of 600,000 IU of vitamin D 3 provided significant pain relief in painful DPN. 188 More data are required before the role of vitamin D supplementation in painful DPN is established.…”

Section: Intravenous Lidocainementioning

confidence: 99%

Diabetic Peripheral Neuropathy: Epidemiology, Diagnosis, and Pharmacotherapy

Iqbal

Azmi

Yadav

et al. 2018

Clinical Therapeutics

375

249

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Section: Intravenous Lidocainementioning

confidence: 99%

Diabetic Peripheral Neuropathy: Epidemiology, Diagnosis, and Pharmacotherapy

Iqbal

Azmi

Yadav

et al. 2018

Clinical Therapeutics

375

249

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“…Although previous studies have evaluated only DN-related pain, our study is the first to evaluate both neuropathic pain and balance. [12][13][14][15]21 Our results showed a significant improvement in the total DN4 questionnaire scores that indicates the presence of neuropathic pain and Berg balance test scores that determines balance after vitamin D replacement therapy. Various considerations are available regarding the dose, administration route, and duration of vitamin D replacement therapy.…”

Section: Discussionmentioning

confidence: 56%

“…Electrophysiological data suggest that the time needed to document the changes in Berg balance test scores is >8 weeks, which corresponds to axonal regeneration time. 21 In the present study, the follow-up examinations were performed after 12 weeks, which allowed for the completion of axonal regeneration. This may explain the discrepancy observed between the results of the present study and those of some previous studies.…”

Section: Discussionmentioning

confidence: 99%

<p>Does Vitamin D Affect Diabetic Neuropathic Pain and Balance?</p>

Sarı¹,

Altun²,

Karaman³

et al. 2020

JPR

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Purpose: This randomized, placebo-controlled study examined the effect of vitamin D replacement therapy on neuropathic symptoms and balance in patients with diabetic neuropathic pain and low vitamin D levels. Patients and Methods: Among the 258 patients, the results in a total of 57 volunteers (32 in the treatment and 25 in the control arm) meeting the inclusion criteria are reported. Symptoms of neuropathic pain were assessed using Douleur Neuropathique 4 (DN4) questionnaire, and presence of polyneuropathy (PNP) was determined by performing electromyography (EMG). Balance was assessed using Berg balance test (BBT). After undergoing these examinations, the patients in the treatment group were intramuscularly (IM) injected with 300,000 IU vitamin D in a liquid formulation and those in the placebo group were IM injected with physiological saline. The DN4 and BBT were repeated after 12 weeks, and the results were compared. Results: The patients in the treatment group showed a significant decrease in total DN4 scores from baseline to the study endpoint compared with the patients in the placebo group (p=0.008). The patients in the treatment group also showed a significant increase in BBT scores from baseline to the study endpoint compared with the patients in the placebo group (p=0.001). Furthermore, in subgroup analysis, these patients showed a significant decrease in electric shock and burning sensation scores from baseline to the study endpoint compared with the patients in the placebo group (p=0.006, p=0.001, respectively). Conclusion: In patients with diabetic neuropathic pain, vitamin D levels should be measured and vitamin D replacement therapy should be administered as required to resolve neuropathic symptoms and to improve balance.

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“…However, taking into account that the inclusion criteria and (Pilz et al, 2011). Finally, vitamin D deficiency could contribute to ED occurrence as a consequence of neuropathy, especially given the fact that erection is a neuro-vascular event and vitamin D deficiency is likely to be associated with neuropathy (Lv et al, 2015). Finally, vitamin D deficiency could contribute to ED occurrence as a consequence of neuropathy, especially given the fact that erection is a neuro-vascular event and vitamin D deficiency is likely to be associated with neuropathy (Lv et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

“…Notably, because not all included seven studies for the meta-analysis evaluated the testosterone levels and excluded the cases with the lower reference range testosterone levels, we were unable to give a definite conclusion that ED was resulted from testosterone deficiency solely in this case. Finally, vitamin D deficiency could contribute to ED occurrence as a consequence of neuropathy, especially given the fact that erection is a neuro-vascular event and vitamin D deficiency is likely to be associated with neuropathy (Lv et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Serum vitamin D levels and erectile dysfunction: A systematic review and meta-analysis

2018

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Suboptimal levels of serum vitamin D levels have been implied to be associated with cardiovascular diseases and endothelial dysfunction, conditions closely associated with erectile dysfunction (ED). The present systematic review and meta-analysis was performed to evaluate the vitamin D levels in subjects with ED compared to controls and the 5-item version of the international index of erectile function (IIEF-5) score in subjects with vitamin D deficiency compared to those without vitamin D deficiency in order to elucidate the role of vitamin D in the pathogenesis of ED. Studies evaluating the possible association between vitamin D levels and ED were initially screened and thus included following electronic literature search of database Cochrane Library, PUBMED, EMBASE and MEDLINE. Essential article information including outcome measures was extracted from the qualified studies by two independent authors, and STATA 12.0 software was used conducted the meta-analysis. Subgroup analyses were conducted by vitamin D detection methods and sample size. The standard mean difference (SMD) as well as the 95% confidence intervals (95% CIs) was applied to estimate the outcome measures. A total of seven articles were included in our meta-analysis with a total of 4,132 subjects. Pooled estimate was in favour of increased vitamin D levels in subjects without ED with a SMD of 3.027 ng/ml, 95%CI 2.290-3.314, p = 0.000. However, subgroup analysis showed an opposite trend, after one study with a sample size over 1,000 that could possibly influence the weight balance was excluded, with a SMD of 0.267, 95%CI −0.052 to 0.585, p = 0.101. We also identified about 0.320 higher in IIEF-5 score (95%CI = 0.146-0.494, p = 0.000) in subjects without vitamin D deficiency versus with vitamin D deficiency. Nevertheless, subgroup analysis based on vitamin D detection methods obtained differential results (radioimmunoassay subgroup, SMD(95%CI) = 0.573 (0.275-0.870), p = 0.000; immunoassay subgroup, SMD(95%CI) = 0.189 (−0.025 to 0.404), p = 0.084). In conclusion, results from the present meta-analysis did not provide a strong relationship between vitamin D and the risk of ED. However, the results should be interpreted with caution and more high quality studies are warranted. K E Y W O R D S5-item version of the international index of erection function, erectile dysfunction, metaanalysis of VD and ED, meta-analysis, vitamin D

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Serum 25-hydroxyvitamin D levels and peripheral neuropathy in patients with type 2 diabetes: a systematic review and meta-analysis

Abstract: Vitamin D is involved in the development of DPN in type 2 diabetic patients, and vitamin D deficiency is very likely to be associated with DPN in type 2 diabetic patients. Further studies are needed to validate the association between vitamin D deficiency and DPN.

Cited by 81 publications

References 29 publications

Diabetic Peripheral Neuropathy: Epidemiology, Diagnosis, and Pharmacotherapy

Diabetic Peripheral Neuropathy: Epidemiology, Diagnosis, and Pharmacotherapy

<p>Does Vitamin D Affect Diabetic Neuropathic Pain and Balance?</p>

Serum vitamin D levels and erectile dysfunction: A systematic review and meta-analysis

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