Serum 25-Hydroxyvitamin D Levels in Pediatric Burn Patients

Abstract

BackgroundPrevious studies have implicated the important and active role of vitamin D in the immune system.ObjectivesThe aim of this study was to evaluate serum levels of 25-hydroxyvitamin D in children with burn injuries.Materials and MethodsIn this cross-sectional study, 118 patients with various degrees of burn injuries were enrolled. A checklist consisting of demographic data, total body surface area (TBSA) affected by burn, degree of burn, serum level of 25(OH)D, total protein, albumin, electrolytes, and parathyroid hormone was recorded for each patient.ResultsSixty-eight (57.6%) males and 50 (42.4%) females with a mean age of 4.04 years (SD = 3.04) were evaluated. The mean level of 25(OH)D was 14.58 ng/mL (SD = 6.94). Levels of 25(OH)D in four (3.39%) cases were higher than 30 ng/mL, while 95 (81.35%) cases had levels lower than 20 ng/mL, and 19 (16.10%) cases had levels of 21 - 30 ng/mL. The level of 25(OH)D was below recommended levels in 96.61% of cases, while 81.34% had vitamin D deficiency and 16.1% had insufficiency. We found a significant correlation between vitamin 25(OH)D and total protein, albumin, and total and ionized calcium (P < 0.001). There was also a significant negative correlation between 25(OH)D and TBSA affected by burn (P = 0.001).ConclusionsThe levels of 25(OH)D in children suffering from severe burns were low. Supplementation might be useful in patients with very low levels of serum vitamin D.

Calcemic response to burns differs between adults and children: A review of the literature

“…Surprisingly, even the PTH values in the paper of Sobouti et al. [13] were in the low range of the other assays using the same units of expression [4] , [13] even though the normal range for those in the study of Sobouti et al. [13] was not provided.…”

“… [13] were in the low range of the other assays using the same units of expression [4] , [13] even though the normal range for those in the study of Sobouti et al. [13] was not provided. In our adult study [8] , when PTH units were converted from pmol/L to pg/mL, the values of 114.1 ± 96 pg/mL were similar to those given by Rousseau et al.…”

“…A paper by Sobouti et al. [13] included 118 pediatric subjects but half of the study subjects had burns between 1% and 30% total body surface area. This was the only pediatric paper we encountered that published data on patients with minor burns.…”

“… [12] from Shriners Burns Hospital in Cincinnati, which studied 50 subjects, giving a total of 60 subjects in all and the one by Sobouti et al. [13] adding another 118 subjects. For the adults there were 4 studies, that from our institution [8] and that of Rousseau et al.…”

The Prevalence of Vitamin D Deficiency Among Children of 1 - 6 Years Old, Tehran, Iran

“…In this regard, three studies were conducted in On the other hand, some studies showed higher prevalence rates for vitamin D deficiency in children compared with the present study; however, they have overlooked the effective health factor of the major organs in vitamin D production cycle. Sobouti et al (24) studied 118 children with a mean age of 4.04 years old with different degrees of burns in Tehran for two years. The prevalence of vitamin D deficiency (level lower than 30 ng/mL) was reported 96.61%.…”