Serum 25-Hydroxyvitamin D Measurement in a Large Population Survey with Statistical Harmonization of Assay Variation to an International Standard

Hyppönen, Elina; Turner, Steve; Cumberland, Phillippa; Power, Christine; Gibb, I

doi:10.1210/jc.2007-1279

Cited by 70 publications

(55 citation statements)

References 23 publications

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“…Thrailkill et al (34) found increased urinary excretion of vitamin D binding protein (DBP) in type 1 diabetes patients presenting with albuminuria. This recent finding suggests that reduced levels of 25-OHD might be explained in part by urinary loss of DBP or increased catabolism of vitamin D (34,35). The mechanisms responsible for these lower levels requires further study and are important to undertake given that lower levels of vitamin D are known to contribute to osteoporosis, a late complications of diabetes and diabetic cardiovascular and renal disease (36e38).…”

Section: Discussionmentioning

confidence: 99%

Type 1 Diabetes as a Risk Factor for Impaired Vitamin D Status in a Multi-Ethnic Cohort of Canadian Adolescents

Yeshayahu

Sochett

Deda

et al. 2012

Canadian Journal of Diabetes

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Section: Discussionmentioning

confidence: 99%

Type 1 Diabetes as a Risk Factor for Impaired Vitamin D Status in a Multi-Ethnic Cohort of Canadian Adolescents

Yeshayahu

Sochett

Deda

et al. 2012

Canadian Journal of Diabetes

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“…Serum 25(OH)D concentrations were measured using an automated IDS OCTEIA ELISA with a Dade-Behring BEP2000 analyzer, standardized according to the mean vitamin D external quality assessment scheme (32). Serum IGF-1 concentration was measured using the Nichols Advantage IGF-1 chemiluminescence immunoassay referenced against World Health Organization 1st International Reference Reagent 1988; IGF-1 87/518.…”

Section: Methodsmentioning

confidence: 99%

25-Hydroxyvitamin D, IGF-1, and Metabolic Syndrome at 45 Years of Age

Hyppönen¹,

et al. 2008

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OBJECTIVE-Hypovitaminosis D and reduced IGF-1 are associated, individually, with metabolic syndrome. Physiological interactions between vitamin D and IGF-1 are reported; this is the first study to investigate their combined associations with metabolic syndrome prevalence. RESEARCH DESIGN AND METHODS-Data on 25-hydroxyvitamin D (25(OH)D), IGF-1, and metabolic syndrome abnormalities (abdominal obesity; raised A1C, blood pressure, and triglycerides; and low HDL cholesterol) were collected from 6,810 British white subjects in the 1958 cohort, surveyed during 2002-2004 (age 45 years). RESULTS-IGF-1 concentrations increased with 25(OH)D up toϳ75-85 nmol/l but not thereafter. Both 25(OH)D and IGF-1 were inversely associated with metabolic syndrome. There was an interaction between 25(OH)D and IGF-1 (P ϭ 0.025) on metabolic syndrome prevalence: IGF-1 was not significantly associated with metabolic syndrome among those with the lowest levels of 25(OH)D (P Ͼ 0.09), whereas higher 25(OH)D was associated with metabolic syndrome at all IGF-1 concentrations (P Յ 0.006). Metabolic syndrome prevalence was lowest for participants with the highest concentrations of both 25(OH)D and IGF-1 (odds ratio for highest vs. lowest third of both 0.26 [95% CI 0.17-0.40], P Ͻ 0.0001; adjusted for sex, month, hour, inactivity, alcohol consumption, smoking, and social class). 25(OH)D was associated with the prevalence of high A1C, blood pressure, and triglycerides after adjustment for IGF-1, obesity, and social and lifestyle variations (P Յ 0.004 for all comparisons). (1,2); however, for both factors, lower concentrations have been associated with disturbed glucose metabolism (3-8), high blood pressure (9 -11), adverse lipid profiles (2,12,13), and cardiovascular disease (8,14,15) independently of body mass. The evidence for associations between vitamin D and IGF-1 axes with metabolic risk includes prospective studies, clinical trials, and dose-related effects, suggesting that associations may prove to be causal. Mechanisms by which vitamin D and IGF-1 axes may lead to human disease are, however, not fully understood, and despite evidence for physiological interaction between these risk factors (16 -18), little is known about their joint effects, and we can find no previous studies investigating their combined associations with metabolic syndrome. CONCLUSIONS-SerumVitamin D is a hormone precursor, which before exerting its metabolic effects undergoes two successive hydroxylations.

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“…Программа присуждает сертифи-кат качества, если целевая производительность ла-боратории соответствовала нахождению 80% всех результатов в диапазоне ± 30% от ALTM, что в 2013 г. было достигнуто только 59% лабораторий [79,80]. Таким образом, одним из путей может быть полу-чение статистического фактора коррекции между методами [81].…”

Section: клинические рекомендацииunclassified

Russian Association of Endocrinologists recommendations for diagnosis, treatment and prevention of vitamin D deficiency in adults

Pigarova¹,

Рожинская²,

Белая³

et al. 2016

Probl Endokrinol (Mosk)

144

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Background. Adequate intake of vitamin D and its concentration in serum is important for the health of bones and calcium-phosphorus metabolism and for the optimal functioning of many organs and tissues. Most epidemiological studies have shown that vitamin D deficiency is widespread among the population in Russian Federation.Material and methods. We reviewed relevant literature on the epidemiology of insufficiency and deficiency, skeletal and extraskeletal effects of vitamin D and summarized recommendations for the diagnosis, prevention and treatment of vitamin D deficiency in the general population, which were subsequently discussed and amended in conjunction with leading endocrinologists of the Russian Federation who are experts in this subject.Results. The optimal concentration of 25(OH)D in the serum as the best indicator of vitamin D body stores is recognized as 30—100 ng/ml (75—250 nmol/l), insufficiency — from 20 to 30 ng/ml (50 to 75 nmol/l), deficiency — less than 20 ng/ml (less than 50 nmol/l). In prevention and treatment it is recommended to stick to the target serum levels of 25(OH)D in the range of 30—60 ng/ml (75—150 nmol/l). We’ve developed a general practice recommendations for the prevention, diagnosis and treatment of vitamin D deficiency in adults, including pregnant and lactating women, persons over 50 years old and subjects suffering from various diseases affecting the metabolism of vitamin D.Conclusions. Increased sufficiency of vitamin D in the population should be included as one of the priorities of modern healthcare due to proven preventive health effects on the musculoskeletal system and the potential positive impact on many socially significant diseases. This publication is a detailed version of the Federal Guideline.

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Serum 25-Hydroxyvitamin D Measurement in a Large Population Survey with Statistical Harmonization of Assay Variation to an International Standard

Abstract: Differences between assays have implications for public health messages about hypovitaminosis D. Harmonization of results with DEQAS enabled the use of previously determined cutoffs for hypovitaminosis D.

Cited by 70 publications

References 23 publications

Type 1 Diabetes as a Risk Factor for Impaired Vitamin D Status in a Multi-Ethnic Cohort of Canadian Adolescents

Type 1 Diabetes as a Risk Factor for Impaired Vitamin D Status in a Multi-Ethnic Cohort of Canadian Adolescents

25-Hydroxyvitamin D, IGF-1, and Metabolic Syndrome at 45 Years of Age

Russian Association of Endocrinologists recommendations for diagnosis, treatment and prevention of vitamin D deficiency in adults

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