Serum 25-Hydroxyvitamin D, Osteocalcin, and Parathormone Status in Children with Meningomyelocele

Okurowska-Zawada, Bożena; Kozerska, Agata; Żelazowska, Beata; Kułak, Wojciech; Wasilewska, Anna; Wysocka, Jolanta

doi:10.1055/s-0032-1327126

Cited by 10 publications

(18 citation statements)

References 29 publications

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“…Of these, 11 articles met the inclusion criteria [13][14][15][16][17][29][30][31][32][33][34]. Although not yielded by the search criteria, five additional articles on this topic were identified and included [35][36][37][38][39]. Thus, 16 articles about BMD and SB were analysed in detail.…”

Section: Resultsmentioning

confidence: 99%

“…Bone densitometry has been the technique of choice for the evaluation of BMD in studies involving patients with MMC. However, the available studies have used either single-energy beam absorptiometry [13,36,37] or dual-energy beam absorptiometry (DXA) [14,29,31,33,35] as well as different types of apparatuses, making it difficult to compare the results.…”

Section: Bmd Assessmentmentioning

confidence: 99%

“…A decrease in BMD is correlated with an increase in the neurological level of the lesion [17,35,36,41] and with lower ambulatory ability [14,33,36,41].…”

Section: Evaluation Of Bmd In Sb -General Conceptsmentioning

confidence: 99%

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Update on bone fragility in spina bifida

Marreiros¹

2018

PRM

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BACKGROUND CONTEXT: Patients with spina bifida (SB) are at risk for pathological fractures and low bone mineral density (BMD). PURPOSE AND METHODS: This article reviews the literature and provides a comprehensive overview of how the characteristics of SB and its associated comorbidities intersect with bone fragility to identify possible pathophysiological mechanisms of fractures and low BMD. RESULTS: Bone fragility occurs early in the life of patients with SB as a result of a disturbance that determines changes in bone shape, quantity, and quality, as poor mineralization reduces bone stiffness. Bone fragility in SB occurs due to local and systemic factors and may be considered a state of impaired bone quality of multifactorial aetiology, with complex interacting influences of neurological, metabolic, and endocrinological origins and the presence of smaller bones. Bone fragility should be evaluated globally according to skeletal age and Tanner staging. The phases of the evolution of Charcot joints seem to intercept the evolution of epiphyseal fractures. Charcot arthropathy in SB may be initiated by the occurrence of repetitive trauma and fractures in epiphyseal and subepiphyseal regions, where there is a deficit of bone mineralization and greater bone mass deficits. CONCLUSION: Bone fragility in MMC potentially has a multifactorial neuro-endocrinological-metabolic-renal dimension, with smaller bones, lower bone mass, and mineralization deficits affecting bone strength.

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Section: Resultsmentioning

confidence: 99%

Section: Bmd Assessmentmentioning

confidence: 99%

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Update on bone fragility in spina bifida

Marreiros¹

2018

PRM

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“…There was a significant correlation between serum 25-hydroxyvitamin D (25[OH]D) and osteoporosis, concluding that vitamin D supplementation may be helpful. 3 There is insufficient evidence that weight-bearing activities are an effective intervention to improve bone density; however, there is also inadequate evidence to support the use of vitamin D supplementation to decrease fractures. 4 A general rule is to supplement with double the recommended dietary allowance amount for age ( Table 2).…”

Section: Musculoskeletal Complicationsmentioning

confidence: 99%

Common Complications of Pediatric Neuromuscular Disorders

Skalsky¹,

Dalal²

2015

Physical Medicine and Rehabilitation Clinics of North America

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“…The estimated prevalence of MMC is 1/700 live births. MMC remains the most severe form of neural tube defects, involving dysfunctions of many organs and structures [2].…”

Section: Introductionmentioning

confidence: 99%

The role of selected parental and perinatal factors in the future mobility of children with myelomeningocele

Korzeniecka‐Kozerska¹,

Bagińska²,

Liszewska³

et al. 2016

fmpcr

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A -study Design, B -Data Collection, C -statistical analysis, D -Data interpretation, E -Manuscript Preparation, F -Literature search, G -Funds Collection Background. Myelomenigocele (MMC) is the most severe form of spina bifida, caused by genetic and environmental components; it has many serious complications in a patient's future life, where dysfunctional mobility is one of the most troublesome. Objectives. The aim of our study was to explore the role of selected factors: parental and perinatal in children with myelomenigocele and correlate them with their future motor function. Material and methods. This retrospective analysis was based on 95 births that occurred from 1985 to 2013. Clinical data were collected using medical records and supplemented by a questionnaire for parents. standard deviation of WHo scores (Z-scores) for weight, length, and body mass index (BMi) at birth were calculated. Hoffer's scale was used to assess MMC children's motor function.Results. There were no statistically significant differences between 53 girls and 42 boys who were enrolled in the study, excluding the month of conception. The tested parameters did not vary substantially according to maternal age. Maternal age correlated positively with paternal age at conception, birth order, and stillbirth rate. Mode of delivery was strongly associated with apgar scale and birth weight. apgar score, birth length, and thus WHo Z-score for length-for-age had positive correlations with future mobility of MMC children. Conclusions. 1. Perinatal factors have a significant effect on children's physical activity. 2. There is no clinical evidence that cesarean section improves early neurological outcome of MMC infants. 3. Parental factors, particularly maternal age, do not determine the future mobility of children with myelomeningocele. Key words: myelomeningocele, parental factors, perinatal factors, motor function.Wstęp. Przepuklina oponowo-rdzeniowa jest najcięższą postacią rozszczepu kręgosłupa, której przyczyny mogą być genetyczne i środowiskowe; daje wiele ciężkich powikłań w przyszłym życiu pacjentów, wśród których trudności w poruszaniu się są jednymi z najbardziej uciążliwych. Cel pracy. ocena wybranych czynników: rodzicielskich i okołoporodowych i ich korelacja z czynnością motoryczną dzieci z przepukliną oponowo-rdzeniową. Materiał i metody. Retrospektywnej analizie poddano 95 historii pacjentów objętych opieką w latach od 1985 do 2013. Dane zostały uzupełnione wywiadem od rodziców dzieci. Dla takich parametrów jak: ciężar ciała, długość oraz wskaźnik masy ciała (BMi) w momencie urodzenia wyliczono odchylenia standardowe według WHo. Do oceny czynności motorycznej uży-to skali Hoffera. Wyniki. nie wykazano istotnych statystycznie różnic między 53 dziewczynkami i 42 chłopcami, z wyjątkiem miesiąca urodzenia. Wartości badanych parametrów nie różniły się istotnie w zależności od wieku matki. Wiek matki korelował pozytywnie z wiekiem ojca w momencie poczęcia dziecka, rodzajem porodu i częstością poronień. Rodzaj porodu korelował ze skalą ...

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Serum 25-Hydroxyvitamin D, Osteocalcin, and Parathormone Status in Children with Meningomyelocele

Cited by 10 publications

References 29 publications

Update on bone fragility in spina bifida

Update on bone fragility in spina bifida

Common Complications of Pediatric Neuromuscular Disorders

The role of selected parental and perinatal factors in the future mobility of children with myelomeningocele

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