Serum 25-hydroxyvitamin D, parathyroid hormone, calcium intake, and bone mineral density in Spanish adults

Olmos, José M.; Hernández, José L.; García-Velasco, P.; Martínez, Josefina; Llorca, Javier; González‐Macías, Jesús

doi:10.1007/s00198-015-3219-6

Cited by 66 publications

(42 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…High prevalence of vitamin D deficiency in alcohol-abusing populations were well documented by previous studies [38,39], while some researchers argued that moderate alcohol consumption showed a positive association with plasma levels of 25(OH)D [40,41]. In line with the findings by Olmos and et al [29], it was shown in our study that alcohol drinking was an independent factor inversely associated with the serum concentrations of 25(OH)D (β=-3.126, P=0.031). Neupane and et al found that shorter time since last alcohol intake was related to having lower 25(OH)D levels [38].…”

Section: Discussionsupporting

confidence: 77%

“…Therefore, an inverse association between serum 25(OH)D and PTH has been well established [28]. In accordance with the results by Olmos and coworkers [29], we found that serum PTH was an independent factor (β=-0.072, P=0.002) negatively associated with the serum levels of 25(OH)D. As expected, we also demonstrated that serum calcium was an independent factor positively associated with the serum concentrations of 25(OH)D (β=17.429, P＜0.0001) in the study. Consequently, to keep adequate serum calcium levels may be an approach to sufficient serum 25(OH)D, by means of increasing the intake of dietary calcium or taking calcium supplements [30].…”

Section: Discussionsupporting

confidence: 74%

See 1 more Smart Citation

Independent factors associated with serum levels of 25- Hydroxyvitamin D in very elderly Chinese males

Bian¹,

Shou²,

Wang³

et al. 2017

Rheumatol Orthop Med

View full text Add to dashboard Cite

Background: Vitamin D deficiency has been associated with a wide variety of chronic diseases and even all-cause mortality. Data on serum 25-hydroxyvitamin D [25(OH)D] and its independent factors in very elderly (aged 80 years or more) males remain to be fully explored. This study was designed to identify independent factors associated with the serum levels of 25(OH)D in very elderly Chinese males.

show abstract

Section: Discussionsupporting

confidence: 77%

Section: Discussionsupporting

confidence: 74%

Independent factors associated with serum levels of 25- Hydroxyvitamin D in very elderly Chinese males

Bian¹,

Shou²,

Wang³

et al. 2017

Rheumatol Orthop Med

View full text Add to dashboard Cite

show abstract

“…Finally we compared our data on calcidiol plasma levels with those of a healthy cohort with 657 men and 1,154 women recently published in Spain by Olmos et al [21].…”

Section: Resultsmentioning

confidence: 99%

“…G3a (Mildly to moderately decreased, 45-59), G3b (Moderately to severely decreased, [30][31][32][33][34][35][36][37][38][39][40][41][42][43][44], G4 (Severely decreased [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29] and G5 (Kidney failure <15). CKD is defined as either an eGFR <60 ml/min/1.73 m 2 or evidence of kidney injury such as a urinary albumin/creatinine ratio (UACR) >30 mg/g [1].…”

Section: The Kdigo 2012 Clinical Practice Guidelines For the Evaluatimentioning

confidence: 99%

Important abnormalities of bone mineral metabolism are present in patients with coronary artery disease with a mild decrease of the estimated glomerular filtration rate

et al. 2015

View full text Add to dashboard Cite

Chronic kidney disease mineral bone disorder (CKD-MBD) is characterized by increased circulating levels of parathormone (PTH) and fibroblast growth factor-23 (FGF23), bone disease and vascular calcification, and is associated with adverse outcomes. We studied the prevalence of mineral metabolism disorders, and the potential relationship between decreased estimated glomerular filtration rate (eGFR) and CKD-MBD in coronary artery disease patients in a cross-sectional study of 704 outpatients 7.5±3.0 months after an acute coronary syndrome. Mean eGFR (CKD-EPI formula) was 75.8±19.1 ml/min/1.73 m 2 . Our patients showed lower calcidiol plasma levels than a healthy cohort from the same geographical area. In the case of men, this finding was present in spite of similar creatinine levels in both groups and older age of the healthy subjects. Most patients (75.5%) had an eGFR<90 ml/min/1.73 m 2 (G2-G5 CKD stages) vitamin D levels were the main independent determinants of serum PTH. Mean FGF23 levels were 69.9 (54.5-96.3) RU/ml, and 33% of patients had FGF23>85.5 RU/mL. This value was 18.4% in G1, 30.0% in G2, and 59.2% in G3-5 (p<0.001). In multivariate analysis, eGFR was the main predictor of PTH and FGF23 levels. Increased phosphate levels were present in 0.7% of the whole sample, 0% in G1, 0.3% in G2 and 2.8% in G3-5 (p=0.011). Ninety-nine percent of cases showed calcidiol insufficiency without significant differences among the different degrees of eGFR. In conclusion, in patients 4 with coronary artery disease there is a large prevalence of increased FGF23 and PTH levels. These findings have an independent relationship with decreased eGFR, and are evident at eGFR 60-89 ml/min/1.73 m 2 . Then, mild decrements in eGFR must be taken in consideration by the clinician, since they are associated with progressive abnormalities of mineral metabolism.

show abstract

“…Sin embargo, los porcentajes de riesgo de ingestas marginales de calcio, al comparar con las EAR, es del 41% de las mujeres menopáusicas. Otros estudios muestran ingestas de Ca que oscilan entre 626 y 644 mg/día en mujeres posmenopáusicas y hombres mayores de 50 años, o el estudio INDICAP en población adulta española, que observa ingestas de 991 mg/día (14)(15)(16)(17).…”

Section: Ingestas De Calcio En Españaunclassified

El calcio, esencial para la salud

Victoria¹

2016

Nutr Hosp

View full text Add to dashboard Cite

Calcium (Ca) is the most abundant mineral element in our body. It accounts for about 2% of body weight. The functions of calcium are: a) functions skeletal and b) regulatory functions. Bone consists of a protein matrix that mineralizes mainly with calcium (the most abundant), phosphate and magnesium, for it is essential an adequate dietary intake of Ca, phosphorus and vitamin D. The ionic Ca (Ca 2+ ) is essential to maintain and / or perform different specialized functions of, virtually, all body cells cellular. Because of its important functions Ca 2+ must be closely regulated, keeping plasma concentrations within narrow ranges. For this reason there is an accurate response against hypocalcemia or hypercalcemia in which the parathormone, calcitriol, calcitonin and vitamin K are involved. Ca intakes in the Spanish population are low in a signifi cant percentage of the older adult's population, especially in women. The main source of Ca in the diet is milk and milk derivatives. Green leafy vegetables, fruits and legumes can be important sources of Ca in a Mediterranean dietary pattern. The bioavailability of dietary Ca depends on physiological and dietary factors. Physiological include age, physiological status (gestation and lactation) Ca and vitamin D status and disease. Several studies relate Ca intake in the diet and various diseases, such as osteoporosis, cancer, cardiovascular disease and obesity. ResumenEl calcio (Ca) es el elemento mineral más abundante en nuestro organismo, ya que forma parte importante del esqueleto y los dientes. Supone alrededor del 2% del peso corporal. Las funciones del calcio son: a) funciones esqueléticas y b) funciones reguladoras. El hueso está formado por una matriz proteica que se mineraliza de forma mayoritaria con calcio (el más abundante), fosfato y magnesio; para ello es imprescindible un correcto aporte dietético de Ca, fósforo y vitamina D. El Ca iónico (Ca 2+ ) es un componente celular imprescindible para mantener y/o realizar las diferentes funciones especializadas de prácticamente todas las células del organismo. Debido a sus importantes funciones, el Ca 2+ debe estar estrechamente regulado, manteniéndose sus concentraciones plasmáticas dentro de unos rangos estrechos. Para ello existe una respuesta precisa frente a la hipocalcemia o la hipercalcemia, en la que intervienen la parathormona, el calcitriol, la calcitonina y la vitamina K. Las ingestas de Ca en la población española son bajas en un porcentaje signifi cativo de la población, especialmente en adultos mayores, sobre todo en las mujeres. La principal fuente de Ca en la dieta son la leche y todos sus derivados. Las verduras de hoja verde, frutas y legumbres pueden tener importancia como fuentes de Ca en un patrón alimentario mediterráneo. La biodisponibilidad del Ca de la dieta depende de factores fi siológicos y dietéticos. Los fi siológicos incluyen la edad, situación fi siológica (gestación y lactación), el estatus de Ca y vitamina D y la enfermedad. Diversos estudios relacionan la ingesta de Ca en ...

show abstract

Serum 25-hydroxyvitamin D, parathyroid hormone, calcium intake, and bone mineral density in Spanish adults

Cited by 66 publications

References 45 publications

Independent factors associated with serum levels of 25- Hydroxyvitamin D in very elderly Chinese males

Independent factors associated with serum levels of 25- Hydroxyvitamin D in very elderly Chinese males

Important abnormalities of bone mineral metabolism are present in patients with coronary artery disease with a mild decrease of the estimated glomerular filtration rate

El calcio, esencial para la salud

Contact Info

Product

Resources

About