Serum 25-hydroxyvitamin D predict prognosis in radioiodine therapy of Graves’ disease

Li, X.; Wang, G.; Lu, Zheng‐Hong; Chen, M.; Tan, Juan; Fang, Xiaonan

doi:10.1007/s40618-015-0252-4

Cited by 19 publications

(18 citation statements)

References 34 publications

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“…Several studies have reported low serum levels of vitamin D in hypothyroid patients which in turn may lead to some musculoskeletal complaints in these patients. [ 8 9 ] Other studies have demonstrated that the patients with Graves’ disease also have low serum levels of vitamin D.[ 10 11 ] There are two mechanisms that may explain why serum levels of vitamin D is low in hypothyroid patients; one is that the low levels of vitamin D may be due to poor absorption of vitamin D from the intestine and the other is the body of these patients may not activate vitamin D properly. [ 8 ] In a study by Chaudhary et al .…”

Section: B Ackgroundmentioning

confidence: 99%

The effects of Vitamin D supplementation on thyroid function in hypothyroid patients: A randomized, double-blind, placebo-controlled trial

Talaei

Ghorbani

Asemi

2018

Indian J Endocr Metab

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Background:Data on the effects of vitamin D supplementation on thyroid function in hypothyroid patients are scarce.Objective:This study was done to evaluate the effects of vitamin D supplementation on thyroid function in hypothyroid patients.Material and Methods:This randomized double-blind, placebo-controlled trial was conducted on 201 hypothyroid patients aged 20–60 years old. Subjects were randomly assigned into two groups to intake either 50,000 IU vitamin D supplements (n = 102) or placebo (n = 99) weekly for 12 weeks. Markers of related with thyroid function were assessed at first and 12 weeks after the intervention.Results:After 12 weeks of intervention, compared to the placebo, vitamin D supplementation resulted in significant increases in serum 25-hydroxyvitamin D (+26.5 ± 11.6 vs. 0.0 ± 0.0 ng/mL, P < 0.001) and calcium (+0.4 ± 0.7 vs. 0.1 ± 0.6 mg/dL, P = 0.002), and a significant decrease in serum thyroid-stimulating hormone (TSH) levels (−0.4 ± 0.6 vs. +0.1 ± 2.0 μIU/mL, P = 0.02). A trend towards a greater decrease in serum parathyroid hormone (PTH) levels was observed in vitamin D group compared to placebo group (−3.8 vs. +1.9, P = 0.07). We did not observe any significant changes in serum T3, T4, alkaline phosphatase (ALP) and albumin levels following supplementation of vitamin D compared with the placebo.Conclusion:Overall, the current study demonstrated that vitamin D supplementation among hypothyroid patients for 12 weeks improved serum TSH and calcium concentrations compared with the placebo, but it did not alter serum T3, T4, ALP, PTH, and albumin levels.

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Section: B Ackgroundmentioning

confidence: 99%

The effects of Vitamin D supplementation on thyroid function in hypothyroid patients: A randomized, double-blind, placebo-controlled trial

Talaei

Ghorbani

Asemi

2018

Indian J Endocr Metab

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“…Genetic variation in genes involved in vitamin D metabolism has been associated with several autoimmune disorders including autoimmune thyroid disease [2-7]. Several studies suggest that individuals with Graves disease (GD) have lower vitamin D levels than the general population [8-11]; however, data on the relationship between the levels of vitamin D and clinical parameters in GD [12, 13] or therapeutic issues [14-16] are limited. The aim of the present study was to compare vitamin D levels in a large number of newly diagnosed patients with GD with those of the general population and to correlate the vitamin D levels at diagnosis with laboratory and clinical parameters in patients with GD.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D in Graves Disease: Levels, Correlation with Laboratory and Clinical Parameters, and Genetics

Planck¹,

Shahida²,

Malm³

et al. 2017

Eur Thyroid J

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Objective: The aim was to compare the vitamin D levels in patients with Graves disease (GD) with the general population and to correlate the vitamin D levels with laboratory and clinical parameters in GD. Moreover, we examined the genetic variation in genes involved in the vitamin D metabolism and their association with GD. Methods: The levels of vitamin D were compared in 292 patients with newly diagnosed GD and 2,305 controls. Single nucleotide polymorphisms (SNPs) in the vitamin D receptor (VDR), vitamin D binding protein (DBP), and 1-α-hydroxylase (CYP27B1) were examined for association with GD and/or Graves ophthalmopathy (GO) in 708 patients and 1,178 controls. Results: Patients with GD had significantly lower vitamin D levels compared to controls (55.0 ± 23.2 vs. 87.2 ± 27.6 nmol/L, p < 0.001). In patients with GD (n = 219), there was no association between the levels of vitamin D at diagnosis and free thyroxine (fT₄), free triiodothyronine (fT₃), thyrotropin receptor antibodies (TRAb), GO at diagnosis, or relapse after terminating treatment with antithyroid drugs. Two SNPs in VDR were associated with GD: rs10735810 (OR = 1.36, 95% CI: 1.02–1.36, p = 0.02) and rs1544410 (OR = 1.47, 95% CI: 1.03–1.47, p = 0.02). There was no difference in the mean vitamin D level between genotypes in either rs10735810 or rs154410. Conclusions: Patients with GD had lower vitamin D levels compared to the general population; however, the vitamin D levels did not affect the laboratory or clinical parameters of GD. SNPs in the VDR influenced the risk of GD through mechanisms other than reducing the vitamin D levels.

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“…The association between vitamin D levels and Graves’ disease is still under debate. Wang et al [ 18 ] conducted the meta-analysis of the association between vitamin D and autoimmune thyroid disease, including the Graves’ disease with 13 studies [ 13 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 ]. However, the study [ 18 ] neither included enough references nor analyzed the sources of high heterogeneity.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D and Graves’ Disease: A Meta-Analysis Update

Cao

Yin

et al. 2015

Nutrients

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The association between vitamin D levels and Graves’ disease is not well studied. This update review aims to further analyze the relationship in order to provide an actual view of estimating the risk. We searched for the publications on vitamin D and Graves’ disease in English or Chinese on PubMed, EMBASE, Chinese National Knowledge Infrastructure, China Biology Medical and Wanfang databases. The standardized mean difference (SMD) and 95% confidence interval (CI) were calculated for the vitamin D levels. Pooled odds ratio (OR) and 95% CI were calculated for vitamin D deficiency. We also performed sensitivity analysis and meta-regression. Combining effect sizes from 26 studies for Graves’ disease as an outcome found a pooled effect of SMD = −0.77 (95% CI: −1.12, −0.42; p < 0.001) favoring the low vitamin D level by the random effect analysis. The meta-regression found assay method had the definite influence on heterogeneity (p = 0.048). The patients with Graves’ disease were more likely to be deficient in vitamin D compared to the controls (OR = 2.24, 95% CI: 1.31, 3.81) with a high heterogeneity (I2 = 84.1%, p < 0.001). We further confirmed that low vitamin D status may increase the risk of Graves’ disease.

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Serum 25-hydroxyvitamin D predict prognosis in radioiodine therapy of Graves’ disease

Abstract: Serum 25(OH)D levels were lower in patients who failed than in those who succeeded in RIT of GD. Therefore, serum 25(OH)D < 20 ng/ml might be an independent risk factor for predicting failure of RIT in GD patients.

Cited by 19 publications

References 34 publications

The effects of Vitamin D supplementation on thyroid function in hypothyroid patients: A randomized, double-blind, placebo-controlled trial

The effects of Vitamin D supplementation on thyroid function in hypothyroid patients: A randomized, double-blind, placebo-controlled trial

Vitamin D in Graves Disease: Levels, Correlation with Laboratory and Clinical Parameters, and Genetics

Vitamin D and Graves’ Disease: A Meta-Analysis Update

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