Serum 25-hydroxyvitamin D status and wheezing in pre-school children, Kuwait

Abdelkader, Alaa; Nassar, May Fouad

doi:10.26719/emhj.18.031

Cited by 5 publications

(3 citation statements)

References 26 publications

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“…Взаимосвязь бронхообструктивного синдрома с высокой частотой развития рекуррентных заболеваний может быть обусловлена также низкой обеспеченностью гидроксихолекальциферолом [37,38] [39,40].…”

Section: факторы риска развития рецидивирующего бронхообструктивного ...unclassified

Bronchial obstruction in pre-school children

Markovskaya

Potapova

Гаймоленко

et al. 2022

Ross. vestn. perinatol. pediatr.

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Based on the analysis of foreign and domestic literature, the authors present the approaches to determining the phenotypes of bronchial obstructive syndrome in preschool children. They outline the data on the main foreign studies devoted to the peculiarities of the bronchial obstruction syndrome course depending on age and clinical outcome. They discuss the risk factors leading to the recurrent course of bronchial obstruction, tools for predicting bronchial asthma, and the choice of phenotype-dependent therapy strategy.

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Section: факторы риска развития рецидивирующего бронхообструктивного ...unclassified

Bronchial obstruction in pre-school children

Markovskaya

Potapova

Гаймоленко

et al. 2022

Ross. vestn. perinatol. pediatr.

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“…[7]; Children whose mothers had sufficient vitamin D status (25Hydroxyvitamin D ≥ 30 ng/mL) at early and late pregnancy and had cord blood vitamin D sufficiency demonstrated a lower risk of asthma/recurrent wheeze than children who had insufficient cord blood vitamin D status at birth [8]; The assessment of circulating 25(OH)D concentration and the optimisation of vitamin D status to prevent acute respiratory tract infections [9]; Serum 25(OH)D was significantly lower in the wheezing group, and its decrease was a risk factor for wheezing. [10]; Lower vitamin D levels in children with STRA were associated with increased ASM mass and worse asthma control and lung function. [11]; Vitamin D deficiency is common among UK adults with ICS-treated asthma, and classical environmental determinants of serum 25(OH)D operate in this population.…”

Section: Introductionmentioning

confidence: 97%

Association Between Asthma Control Status and Lung Function with Vitamin D Level in Children with Bronchial Asthma

Bugadze¹,

Manjavidze²,

Joliani³

2021

ASS

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Bronchial asthma is one of the most common chronic diseases in childhood. Pooled vitD levels were positively correlated with pooled ACT scores, Treg counts, FEV1% values and VDBP levels. Vitamin D supplementation reduced the rate of asthma exacerbation, especially in patients with vitamin D insufficiency. The 25-OH vitamin D levels were lower in pediatric asthma patients with worse spirometry results. Lower vitamin D levels in children with STRA were associated with increased ASM mass and worse asthma control and lung function. Materials and methods: The study was performed in children aged 6 -15 years old, including patients with asthma (n=50), who referred to Sachkhere medical center for a visit. The status of asthma control in the basic group was classified as controlled (n=31) and uncontrolled (n=19). The children underwent serum vitamin D and IgE level, spirometry and skin prick tests for the study. Results: Using the multivariate logistic regression analysis, the presence of asthma was associated with the reduced level of vitamin D (OR=1.35, 95% CI (1,14-1.58) P=0.011; X²=6.78; F-0.022) in children with uncontrolled bronchial asthma. 48% of the patients in the group-controlled asthma (n=15) had vitamin D deficit, and in 52% of the cases (n=16) was confirmed with vitamin D insufficient. In the groupuncontrolled asthma -5% of the patients (n=1) had Vitamin D insufficiency in blood serum. In 95% (n=18) of the patients vitamin D level was significantly low < 20 ng/ml. According the results, decreased pulmonary function (p-0.039; x2-3.12) is strongly associated with low level of vitamin D; but neither serum IgE level (p-0.54; x2-10.9), nor skin prick test result on dust mite (p-0.50, x2-5.12) was correlations with serum vitamin D low level. Conclusion: The presence of vitamin D deficiency effectively predict increased risk of uncontrolled bronchial asthma in children. Serum vitamin D level is related to lung function too. Therefore, by normalize vitamin D level in blood serum maybe improve lung function and control status in children with bronchial asthma.

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“…Public health and environmental factors are examined from two points of view in this issue; first, a therapeutic approach to wheezing among pre-school children through possible benefits of vitamin D supplements, as outlined in the article "Serum 25-hydroxyvitamin D status and wheezing in pre-school children, Kuwait" (5). Second, the implementation of proper waste management practices in hospitals to prevent landfill hazards to local populations, is the focus of the article entitled: "Field lessons in surveying healthcare waste management activities in Pakistan" (6).…”

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confidence: 99%

Editorial

2019

East Mediterr Health J

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The Eastern Mediterranean Health Journal examines a diverse number of topics in this issue that underpin public health-related activities in the Eastern Mediterranean Region (EMR), including research methods, communicable disease prevention, drug administration, and palliative care. In fact, the EMR continues to have some of the most pressing public health challenges brought about by social conflict and health systems degradation, exacerbated by natural disasters, including desertification, floods, earthquakes, and soil erosion. The issue of non-adherence to medication schedules by patients is a topic that receives relatively little attention, yet its observation highlights the added healthcare costs through poor clinical outcomes and higher hospitalization rates. An example of non-compliance with prescribed medication is examined in the article "Adherence to levothyroxine among patients with hypothyroidism in Lebanon" (1), with particular relevance to the growing number of cases of thyroid-related pathologies in the Region. Still, if patients are failing to follow prescriptions from their physicians diligently, then this is not helped by irrational prescription of antibiotics by some physicians, which may result in antibiotic resistance, an issue examined in the article "Practice implications of an antimicrobial stewardship intervention in a tertiary care teach hospital, Qatar" (2). The article "Agenda setting analysis for maternal mortality reduction: exploring influential factors using Kingdon's Stream Model" (3) is a comparative study that analysed the agenda setting process in nine successful countries that achieved MDG 5, looking at similarities and differences in the agenda setting process, and concluded that political stability and commitment are core to its success. Continuing the theme of maternal

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Serum 25-hydroxyvitamin D status and wheezing in pre-school children, Kuwait

Abstract: It included 244 Kuwaiti preschool children (age 2 to 5 years) who presented at the outpatient clinic for vitamin D status evaluation, and were recruited after obtaining consents from the parents or care givers. Full demographic and social data were collected

Cited by 5 publications

References 26 publications

Bronchial obstruction in pre-school children

Bronchial obstruction in pre-school children

Association Between Asthma Control Status and Lung Function with Vitamin D Level in Children with Bronchial Asthma

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