Serum 25–Hydroxyvitamin D3 and Mammography Density among Mexican Women

Abstract

Low circulating levels of vitamin D and high mammographic density (MD) have been associated with higher risk of breast cancer. Although some evidence suggested an inverse association between circulating vitamin D and MD, no studies have investigated this association among Mexican women. We examined whether serum 25−hydroxyvitamin D3 [25(OH)D3] levels were associated with MD in a cross-sectional study nested within the large Mexican Teacher's Cohort. This study included 491 premenopausal women with a mean age of 42.9 years. Serum 25(OH)D3 levels were measured by liquid chromatography/tandem mass spectrometry. Linear regression and non-linear adjusted models were used to estimate the association of MD with serum 25(OH)D3. Median serum 25(OH)D3 level was 27.3 (23.3–32.8) (ng/ml). Forty one (8%) women had 25(OH)D3 levels in the deficient range (< 20 ng/ml). Body mass index (BMI) and total physical activity were significantly correlated with 25(OH)D3 (r = −0.109, P = 0.019 and r = 0.095, P = 0.003, respectively). In the multivariable linear regression, no significant association was observed between 25(OH)D3 levels and MD overall. However, in stratified analyses, higher serum 25(OH)D3 levels (≥27.3 ng/ml) were significantly inversely associated with percent MD among women with BMI below the median (β = −0.52, P = 0.047). Although no significant association was observed between serum 25(OH)D3 and percent MD in the overall population, specific subgroups of women may benefit from higher serum 25(OH)D3 levels.

The Role of Diet, Physical Activity, Body Fatness, and Breastfeeding in Breast Cancer in Young Women: Epidemiological Evidence

“…In addition, a significant inverse dose-response was observed at higher levels of vitamin D associated with lower risk of BC 55 . Similarly, higher serum levels of vitamin D (> 27.3 ng/ml) were significantly inversely associated with lower percent mammographic density among young Mexican women with BMI < 27 kg/m 2 (median value), suggesting that some groups of women may benefit from vitamin D supplementation 56 . Further research is needed to determine the amount of vitamin D necessary to achieve a protective benefit against BC.…”

Impacto Da Associação Entre Vitamina D E Densidade Mamária Na Redução Do Risco De Câncer De Mama

“…Por fim, mais pesquisas são necessárias para entender o efeito da vitamina D na densidade mamográfica e determinar se a suplementação de vitamina D pode ou não desempenhar um papel preventivo no câncer de mama (AMADOU et al, 2016).…”