Serum 25‐hydroxyvitamin <scp>D</scp> increases with <scp>NB‐UVB</scp> and <scp>UVA</scp>/<scp>UVB</scp> phototherapy in patients with psoriasis and atopic dermatitis in <scp>W</scp>estern <scp>A</scp>ustralia

Le, Patricia; Tu, Jenny; Gebauer, Kurt; Brown, Suzanne J.

doi:10.1111/ajd.12315

Cited by 12 publications

(9 citation statements)

References 19 publications

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“…NB-UVB (narrow-band ultraviolet B light) and UVA/UVB phototherapy, widely used in the treatment of psoriasis, are thought to mediate its beneficial effect in part by elevating the serum 25(OH)D level [72,73,74]. A clinical trial compared the efficacy and safety of various treatment regimens for psoriasis (calcipotriol monotherapy, NB-UVB phototherapy alone and combination of calcipotriol and NB-UVB) and demonstrated that the combination of calcipotriol and NB-UVB twice a week was superior to other treatment regimens in rapidly reducing the PASI score of patients [75].…”

Section: Role Of Vitamin D In Certain Inflammatory Skin Diseasesmentioning

confidence: 99%

“…In another study, Drozdenko et al [139] showed that the oral intake of vitamin D increases the frequencies of CD38+ B cells to enhance the B-cell receptor-mediated response and decreases the IFN-γ and IL-17 T-cell cytokine response in vitamin D-deficient individuals. Additionally UVA and UVB phototherapy is widely used in AD treatment because of its effects in the T cell-mediated immune response, and it is suggested that the beneficial effect of UVA/UVB phototherapy is also mediated by the correction of the vitamin D deficiency or insufficiency in AD patients [72]. An increased IgE response to common environmental and food allergens is a common feature in AD.…”

Section: Role Of Vitamin D In Certain Inflammatory Skin Diseasesmentioning

confidence: 99%

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Vitamin D and the Pathophysiology of Inflammatory Skin Diseases

Umar

Sastry

Ali

et al. 2018

Skin Pharmacol Physiol

147

135

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Background: Vitamin D is a secosteroid, which was initially known for its skeletal role; however, in recent years, its functions in different organs have been increasingly recognized. In this review, we will provide an overview of vitamin D functions in the skin physiology with specific focus on its role in certain inflammatory skin conditions such as psoriasis and atopic dermatitis. Methods: A comprehensive literature search was carried out in PubMed and Google Scholar databases using keywords like “vitamin D,” “skin,” “atopic dermatitis,” and “psoriasis.” Only articles published in English and related to the study topic were included in this review. Results: Vitamin D is integrally connected to the skin for its synthesis, metabolism, and activity. It regulates many physiological processes in the skin ranging from cellular proliferation, differentiation, and apoptosis to barrier maintenance and immune functions. Vitamin D deficiency is associated with the risk of psoriasis and atopic dermatitis, and several clinical/observational studies have suggested the beneficial effect of vitamin D in the therapy of these 2 inflammatory skin disorders. Conclusions: Vitamin D exerts a pleiotropic effect in the skin and could be an important therapeutic option for psoriasis and atopic dermatitis.

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Section: Role Of Vitamin D In Certain Inflammatory Skin Diseasesmentioning

confidence: 99%

Section: Role Of Vitamin D In Certain Inflammatory Skin Diseasesmentioning

confidence: 99%

Vitamin D and the Pathophysiology of Inflammatory Skin Diseases

Umar

Sastry

Ali

et al. 2018

Skin Pharmacol Physiol

147

135

View full text Add to dashboard Cite

show abstract

“…Skin biopsies from baseline and at week 4 of nbUVB phototherapy were analysed with RT qPCR for selected cytokine mRNA. This showed no change in IL-10, IL-13, IL-22, IL-33, or IFN-γ mRNA following nbUVB phototherapy ( (11,(21)(22)(23)(24)(25)(26). The lack of effect of FLG loss-of-function mutations on this increase contrasts with epidemiological and experimental studies that have indicated that decreased filaggrin levels in the skin cause higher nbUVB penetration (14)(15)(16)(17)(18)(19).…”

Section: Neither the Phenotype Of The Cd4 + T Cells In The Blood Nor mentioning

confidence: 87%

Increase in Vitamin D but not Regulatory T Cells following Ultraviolet B Phototherapy of Patients with Atopic Dermatitis

Simonsen

Bonefeld²,

Thyssen³

et al. 2019

Acta Derm Venerol

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SIGNIFICANCE Vitamin D synthesis is induced by ultraviolet B irradiation of the skin and may have a beneficial effect on the immune system in patients with atopic dermatitis. We measured changes in vitamin D levels and immunological markers in patients with atopic dermatitis receiving ultraviolet B photo therapy. Following ultraviolet B phototherapy, vitamin D levels were increased, as expected, but no changes were found in the immune system. Furthermore, ultraviolet B phototherapy induced equal increases in the vitamin D levels in patients with atopic dermatitis with and without a mutation that causes a defective skin barrier. This study investigated serum 25-hydroxyvitamin D (25(OH)D) concentrations and circulating regulatory T cells in patients with atopic dermatitis receiving narrow-band ultraviolet B (nbUVB) phototherapy. Thirty adult patients with atopic dermatitis were included. Blood samples were collected at baseline and at weeks 2 and 4 of nbUVB phototherapy. Skin biopsies were taken at baseline and at week 4. Serum 25(OH) D concentrations increased significantly following nbUVB phototherapy (estimate of change from baseline to week 2: 32.00 nmol/l, confidence interval (CI) 20.48-43.52, p < 0.0001, n = 25; and from baseline to week 4: 50.30 nmol/l, CI 37.28-63.33, p < 0.0001, n = 18). This increase was independent of the filaggrin gene loss-of-function mutation status. Flow cytometry showed no significant change in regulatory T cells or cytokine profiles of T cells in blood. Real-time quantitative PCR showed no change in skin cytokine levels. In conclusion, nbUVB phototherapy was associated with increased serum 25(OH)D concentrations, but not changes in circulating regulatory T cells in patients with atopic dermatitis.

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“…The beneficial effect of phototherapy on atopic dermatitis has been associated with positive contributions to vitamin D deficiency or insufficiency. 18,19 In a meta-analysis study, vitiligo was associated with vitamin D deficiency and topical vitamin D analogues and phototherapy have been shown to be effective in the treatment. 20,21 Alopecia areata is a T-cell mediated disease targeting the hair follicle.…”

Section: Discussionmentioning

confidence: 99%