Serum 25(OH)D and incident type 2 diabetes: a cohort study

Husemoen, L L N; Skaaby, Tea; Thuesen, Betina Heinsbæk; Jørgensen, Torben; Fenger, Runa Vavia; Linneberg, Allan

doi:10.1038/ejcn.2012.134

Cited by 52 publications

(35 citation statements)

References 33 publications

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“…Apart from its key role in growth and maintenance of the skeleton, vitamin D affects a great number of genes including genes involved in angiogenesis and cellular proliferation, differentiation, and apoptosis [2]. Circulating vitamin D may play a role in all-cause mortality and diseases like cardiovascular disease (CVD) and diabetes [2,5,[8][9][10][11][12], chronic obstructive pulmonary disease [13], cancer [14], and autoimmune disease [6].…”

Section: Introductionmentioning

confidence: 99%

Longitudinal associations between lifestyle and vitamin D: A general population study with repeated vitamin D measurements

et al. 2015

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Several lifestyle factors have been found to be associated with vitamin D status in cross-sectional studies, but it is not clear whether a change in these factors can actually affect the vitamin D level. We investigated the association between repeated measurements of physical activity, body mass index (BMI), diet, alcohol consumption, and smoking habits, and corresponding levels of vitamin D during 5 years of follow-up of a large general population sample. We included 4185 persons who participated and had vitamin D (serum-25-hydroxyvitamin D, 25-OH-D) measurements in the Inter99 study at baseline (1999-2001) and 5-year follow-up. In a subsample, 25-OH-D was also measured at 1- and 3-year follow-ups. We used mixed models to examine the association between repeated measurements of lifestyle factors and 25-OH-D levels. In multivariable analyses of repeated measurements, the difference in 25-OH-D was -0.32 ng/ml (95 % CI -0.37, -0.28) per 1 kg/m(2) increase in BMI; 4.50 ng/ml (95 % CI 3.84, 5.15) for persons moderately/vigorously physically active versus sedentary; 1.82 ng/ml (95 % CI 1.09, 2.56) for persons with healthy versus unhealthy dietary habits; 0.05 ng/ml (95 % CI 0.03, 0.07) per 1 standard drink/weak increase in alcohol consumption; and 0.86 ng/ml (95 % CI 0.36, 1.35) for never smokers versus daily smokers. Our study shows that lower BMI, a higher level of physical activity, a healthier diet and possibly a higher alcohol intake, and not smoking, are associated with higher 25-OH-D levels.

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Section: Introductionmentioning

confidence: 99%

Longitudinal associations between lifestyle and vitamin D: A general population study with repeated vitamin D measurements

et al. 2015

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“…Moreover, vitamin D can prevent the destruction of pancreatic betacells and reduce the incidence of diabetes mellitus, possibly secondary to inhibition of proinflammatory cytokines [8][9][10]. Higher concentrations of proinflammatory cytokines (such as IL-6, TNF-α) and hs-CRP have been noted especially in subjects with low concentrations of vitamin D [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Effect of Vitamin D Supplementation on Some Inflammatory Biomarkers in Type 2 Diabetes Mellitus Subjects: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Tian

Xiao

et al. 2018

Ann Nutr Metab

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Background/Aims: The mechanism, by which vitamin D influences inflammatory biomarkers in type 2 diabetes mellitus (T2DM), is not very well known. Thus, a meta-analysis of randomized controlled trials was conducted to assess the effect of vitamin D supplementation on some inflammatory biomarkers in T2DM subjects. Methods: We searched randomized controlled trials from PubMed and the Cochrane Library in October 2017 and conducted a meta-analysis to evaluate the effectiveness of vitamin D supplementation on high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6). Either a fixed-effects or a random-effects model was used to calculate pooled effects. Results: We identified 13 studies that met our inclusion criteria. The results indicated that the vitamin D supplementation significant decreased the hs-CRP level by 0.45 μg/mL, whereas the vitamin D supplementation did not influence the TNF-α and IL-6. Subgroup analysis showed that vitamin D significantly lowered hs-CRP by 0.34 μg/mL among trials with a daily vitamin D dose ≤4,000 IU and by 0.31 μg/mL among trials with time of vitamin D supplementation > 12 weeks. Conclusions: Vitamin D supplementation is beneficial for the reduction of hs-CRP inT2DM subjects but does not have a significant influence on TNF-α and IL-6 in T2DM subjects.

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“…The vitamin D receptor is found in most cells of the body and many tissues can convert vitamin D to its active form (1). Vitamin D insufficiency and deficiency are common worldwide and are associated with a number of common diseases, such as cardiovascular risk factors (e.g., hyperlipidemia and albuminuria), diabetes, cardiovascular disease, and mortality (1)(2)(3)(4)(5)(6)(7).…”

Section: Introductionmentioning

confidence: 99%

Prospective Population-Based Study of the Association between Serum 25-Hydroxyvitamin-D Levels and the Incidence of Specific Types of Cancer

Skaaby¹,

Husemoen²,

Thuesen³

et al. 2014

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Observational studies have suggested an inverse association between vitamin D status and cancer. We investigated the prospective associations between vitamin D status and the total and specific type of cancer in three cohorts from the general Danish population.Methods: A total of 12,204 individuals 18 to 71 years old were included. The level of 25-hydroxyvitamin D was measured at baseline, and information about cancer was obtained from the Danish Cancer Registry.Results: During the 11.3-year median follow-up time, there were 1,248 incident cancers. HRs [95% confidence intervals (CI)] per 10 nmol/L higher baseline vitamin D level were: for all cancers (HR ¼ 1.02; 95% CI, 0.99-1.04), all cancers excluding non-melanoma skin cancer, NMSC (HR ¼ 1.00; 95% CI, 0.97-1.03), head and neck cancer (HR ¼ 0.97; 95% CI, 0.84-1.12), colorectal cancer (HR ¼ 0.95; 95% CI, 0.88-1.02), cancer of bronchus and lung (HR ¼ 0.98; 95% CI, 0.91-1.05), breast cancer (HR ¼ 1.02; 95% CI, 0.96-1.09), cancer of the uterus (HR ¼ 1.10; 95% CI, 0.95-1.27), prostate cancer (HR ¼ 1.00; 95% CI, 0.93-1.08), cancer of the urinary organs (HR ¼ 1.01; 95% CI, 0.90-1.14), NMSC (HR ¼ 1.06; 95% CI, 1.02-1.10), and malignant melanoma (HR ¼ 1.06; 95% CI, 0.95-1.17).Conclusions: Apart from a significantly higher risk for NMSC with higher vitamin D status, we found no statistically significant associations between vitamin D status and total or specific cancers.Impact: Our results do not indicate that there is an impact of vitamin D on total cancer incidence. Cancer Epidemiol Biomarkers Prev; 23(7); 1220-9. Ó2014 AACR.

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Serum 25(OH)D and incident type 2 diabetes: a cohort study

Cited by 52 publications

References 33 publications

Longitudinal associations between lifestyle and vitamin D: A general population study with repeated vitamin D measurements

Longitudinal associations between lifestyle and vitamin D: A general population study with repeated vitamin D measurements

Effect of Vitamin D Supplementation on Some Inflammatory Biomarkers in Type 2 Diabetes Mellitus Subjects: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Prospective Population-Based Study of the Association between Serum 25-Hydroxyvitamin-D Levels and the Incidence of Specific Types of Cancer

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