Serum 25-OH vitamin D and insulin resistance in women with polycystic ovary syndrome

Abstract

Background: This was a prospective case control study conducted in the department of obstetrics and gynecology, Era’s Lucknow Medical College and Hospital from November 2018 to March 2020. Aim was to find whether there was a link between serum 25-OH vitamin D levels, and insulin resistance in women with polycystic ovarian syndrome (PCOS). Methods: 30 newly diagnosed cases of PCOS and 30 women without PCOS were enrolled. Their clinical details as well as BMI and waist hip ratio were noted. The biochemical parameters which were measured included fasting glucose, fasting insulin, serum 25-OH vitamin D. The insulin resistance was calculated. Results: 50% of the PCOS had insulin resistance and also deficient /or insufficient vitamin D levels, versus 16.7% in the control group. This association was statistically highly significant with p value as 0.00016. No statistical significance was found with regard to the mean serum 25-OH vitamin D level. 53.4%, of the PCOS women had hirsutism versus 3.3% in the control group and was statistically significant, p value <0.0001. 20% of PCOS women had acne in contrast to 3.3% in the control group which was statistically significant with p value 0.0443. Conclusions: Hirsutism and acne were important clinical signs of PCOS. There was a negative correlation between insulin resistance and serum 25-OH vitamin D levels. Thus, vitamin D may be an important link in the genesis of PCOS. Larger randomised case control studies need to be done to understand PCOS.

Exploring Serum Vitamin D, Sex Hormones, and Lipid Profile Disparities in Women With and Without Polycystic Ovarian Syndrome: A Case-Control Study

“…Vitamin D deficiency has been suggested to contribute to the pathogenesis of insulin resistance and PCOS [10]. Vitamin D deficiency, implicated in PCOS pathogenesis, was evident in our study, aligning with prior research [9,15,22].…”

“…Vitamin D deficiency, implicated in PCOS pathogenesis, was evident in our study, aligning with prior research [9,15,22]. However, discordant findings regarding vitamin D levels among PCOS subjects exist in the literature [10,11,20], underscoring the complexity of this relationship.…”

“…Lifestyle disparities among study populations may contribute to this inconsistency. Notably, acne prevalence was significantly higher in PCOS-affected women in our study compared to controls; this observation was consistent with the findings of Ansari and Chandra [10] and Yadav and Tarware [16]. Similarly, the increased incidence of irregular menstrual cycles in the PCOS…”

“…Unlike Sukul et al and Ezeiruka and Onitsha, who reported a significant disparity in BMI between PCOS subjects and controls [9,14], our study, aligning with Ansari and Chandra [10] and Bindayel [15], observed no significant BMI difference between the two groups. Lifestyle disparities among study populations may contribute to this inconsistency.…”

“…The symptoms of PCOS, including irregular menstruation, decreased chances of getting pregnant, hirsutism, hyperandrogenism, obesity, and elevated risk factors for cardiovascular disease, have been linked to lower vitamin D levels [8]. Nevertheless, inconsistent reports on the prevalence of vitamin D deficiency in PCOS patients have been documented [9][10][11].…”