Serum Activity of Mitochondrial Aspartate Aminotransferase: A Sensitive Marker of Alcoholism With or Without Alcoholic Hepatitis

Nalpas, Bertrand; Vassault, Anne; Guillou, Alain Le; Lesgourgues, Bruno; Ferry, Nicolas; Lacour, Bernard; Berthelot, Pièrre

doi:10.1002/hep.1840040517

Cited by 124 publications

(58 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…25 Elevated ALT is associated with liver parenchyma injury; whereas AST in part is related to its delayed clearance 26 or mitochondrial injury due to advanced fibrosis. 27 These findings are also consistent in the previously conducted studies 23,28 including APRICOT. 13 The FIB-4 index was easy to use; its calculation was swift and simple.…”

Section: Discussionsupporting

confidence: 90%

Fib-4 Index: Diagnostic Validity for Predicting Hepatic Fibrosis in South East Asian Patients of Chronic Hepatitis C Virus (Hcv) Genotype 3 Infection

Shaikh¹,

Zeb²,

Siddiqui³

et al. 2017

TPMJ

View full text Add to dashboard Cite

ABSTRACT… Objectives:To assess the diagnostic validity of FIB-4 for predicting hepatic fibrosis in patients of chronic hepatitis C genotype 3. Study Design: Cross-sectional study. Setting: Department of Gastroenterology and Hepatology, Isra University Hospital, Hyderabad through convenient sampling. Period: June 2013 to June 2014. Methods: Diagnostic validity of FIB-4 index for predicting hepatic fibrosis was determined by measuring sensitivity, specificity, positive productive, negative predictive value, and compared these parameters with liver biopsy. The liver histology was determined by METAVIR score. Results: A total 115 patients were enrolled with mean and SD of age was 39.6 ± 9.3 years. Dividing FIB-4 index into three categories as <1.45, 1.45 -3.25, and >3.25; by using the Obuchowski method the AUROC was 0.93 (with 95% CI 0.91, 0.95). When dividing the FIB-4 index in to three categories as <1.45, 1.45 -<2.25 and >2.25; the AUROC by using Obuchowski method was 0.87 (with 95% CI 0.83, 0.91). Similarly for the diagnosis of Cirrhosis (F = 4 METAVIR) on the predictive value of the non-invasive test FIB-4 while using Obuchowski method the AUROC was 0.85 (with 95% CI 0.83, 0.87). Conclusion: The FIB-4 index is a simple, inexpensive, non-invasive, and a quick test for predicting liver fibrosis in patients of chronic Hepatitis C genotype 3. Key words:Liver biopsy, Metavir, Non-invasive, Cirrhosis, Fibrosis, Pakistan.

show abstract

Section: Discussionsupporting

confidence: 90%

Fib-4 Index: Diagnostic Validity for Predicting Hepatic Fibrosis in South East Asian Patients of Chronic Hepatitis C Virus (Hcv) Genotype 3 Infection

Shaikh¹,

Zeb²,

Siddiqui³

et al. 2017

TPMJ

View full text Add to dashboard Cite

show abstract

“…The difference in the levels of AST,ALT,GGT & AST/ALT ratio in controls and patients were statistically highly significant (p<o.ooo1) with the levels of all these parameters significantly increased in patients as compared to controls. These results were in accordance with S K DAS [22], Irie et al [23] and Nalpas et al [24]. The prevalence of alcoholic liver disease is influenced by many factors including genetic and environmental factors; however the risk of liver disease increases with the quantity and duration of alcohol intake [25].…”

Section: Discussionsupporting

confidence: 86%

Indices of Oxidative Stress and Liver Injury in Alcoholic Liver Disease

Garg¹,

Choudhary²,

Chakraborty³

et al. 2017

IJIMS

View full text Add to dashboard Cite

show abstract

“…(1) The injury to liver cell mitochondria in patients with alcoholic liver disease leads to dominant elevation of serum AST [19] ; (2) The production of aminotransferase in hepatocytes is more disturbed in ALT than in AST [20] ; (3) Patients are defined as having alcoholic liver disease based on pyridoxal 5' phosphatase deficiency, which is important in maintaining aminotransferase activity, especially that of ALT. Although these hypotheses can explain the mechanism of AST/ALT elevation in alcoholic liver disease, AST/ALT elevation cannot be elucidated in cirrhotic patients who do not consume alcohol.…”

Section: Discussionmentioning

confidence: 99%

Aspartate aminotransferase-immunoglobulin complexes in patients with chronic liver disease

Tameda

Shiraki²,

Ooi³

et al. 2005

WJG

View full text Add to dashboard Cite

AIM:To determine the complex of AST and immunoglobulin and to investigate its clinical significance in patients with liver disease. METHODS:The complex of AST and immunoglobulin was determined by encounter immunoelectrophoresis and its clinical significance was investigated in 128 patients with liver disease. RESULTS:AST was bound to immunoglobulin of antiimmunoglobulin A (IgA) class, but any binding to antiimmunoglobulin G and anti-immunoglobulin M classes was not observed. Although the incidence of ASTimmunoglobulin complex was 41.8% in chronic hepatitis (CH), the incidences in liver cirrhosis and hepatocellular carcinoma were 62.2 and 90.0%, respectively. In alcoholic liver disease with high level of serum IgA, the incidence of the complex was 66.7%, which was higher than that in CH. The ratio of binding to lambda-chain of IgA was higher than that to kappa-chain of IgA. The serum level of IgA and the ratio of AST/alanine aminotransferase (ALT) were significantly higher in patients with AST-IgA complex than in those without complex. CONCLUSION:These results suggest that AST-IgA complex in patients with progressive liver diseases and alcoholic liver injury can lead to elevation of the ratio of AST/ALT.

show abstract

Serum Activity of Mitochondrial Aspartate Aminotransferase: A Sensitive Marker of Alcoholism With or Without Alcoholic Hepatitis

Cited by 124 publications

References 15 publications

Fib-4 Index: Diagnostic Validity for Predicting Hepatic Fibrosis in South East Asian Patients of Chronic Hepatitis C Virus (Hcv) Genotype 3 Infection

Fib-4 Index: Diagnostic Validity for Predicting Hepatic Fibrosis in South East Asian Patients of Chronic Hepatitis C Virus (Hcv) Genotype 3 Infection

Indices of Oxidative Stress and Liver Injury in Alcoholic Liver Disease

Aspartate aminotransferase-immunoglobulin complexes in patients with chronic liver disease

Contact Info

Product

Resources

About