Serum adipocyte fatty acid-binding protein levels are independently associated with sarcopenic obesity

Kim, Tae Nyun; Won, Jong Chul; Kim, You Jeong; Lee, Eun Ju; Kim, Mi-Kyung; Park, Man Sik; Lee, Seong Keon; Kim, Jung Min; Ko, Kyung Soo; Rhee, Byoung Doo

doi:10.1016/j.diabres.2013.05.014

Cited by 23 publications

(25 citation statements)

References 38 publications

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“…In individuals with SO the relative scarcity of myokines comparedto adipokines increase the risk of CVD and CMD (32,40). A new adipokine, A-FABP (adipocyte fatty acid-binding protein), has been described as a link between obesity, inflammatoty process and insulin resistance and may be involved in the pathogenesis of SO (12). It is predominantly expressed in the adipocyte and macrophage and a significant portion is released in the bloodstream.…”

Section: Sarcopenic Obesity (Definition Diagnosis and Physiopathology)mentioning

confidence: 99%

“…It is possible that A-FABP works as a lipid hormone transporter or in an hormone-like fashion to modulate the systemic insulin sensibility and the energy metabolism. Some studies show that A-FABP are positively associated to body fat and negatively to MM and in human, it is associated with severity of insulin resistance and its consequences (12). Besides the inflammatory process and insulin resistance, leptin is highlighted in the physiopathology of SO.…”

Section: Sarcopenic Obesity (Definition Diagnosis and Physiopathology)mentioning

confidence: 99%

“…The main changes of BC are related to excess of adipose tissue (AT) and/or the deficit of muscular mass (MM), defined as obesity, sarcopenia or sarcopenic obesity (SO), when both conditions appear simultaneously (1). The prevalence of SO has increased in industrialized countries due to the high number of cases of obesity and sarcopenia in obese people, ranging from 4.4% to 42.9%, depending on the diagnostic methods and on the studied population (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21). There is not a consensus between the definition and classification of SO, and this gap contributes to the inconsistent findings in its association with clinical outcomes (22)(23)(24).…”

Section: Introductionmentioning

confidence: 99%

“…Knowledge about the consequences of the SO to health were initially limited to functional outcomes. Recently, the associations between this condition and cardiometabilic disease (CMD), cardiovascular disease (CVD) and mortality has been the target of growing attention (12,22,25), justifying the study of these relationship since SO can be prevented or treated.…”

Section: Introductionmentioning

confidence: 99%

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Association between sarcopenic obesity and cardiovascular risk: where are we?

Gusmão-Sena¹,

Curvello-Silva

Barreto-Medeiros

et al. 2016

Nutr Hosp

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ResumenIntroducción: los principales cambios en la composición del cuerpo refi eren el incremento de tejido adiposo y/o la disminución de masa muscular, y estos cambios tienen efecto en varios resultados clínicos. La obesidad sarcopénica (OS) consiste en la presencia simultánea del exceso de tejido adiposo y el défi cit de masa muscular. Las personas con OS pueden tener un efecto sinérgico debido a la obesidad y la sarcopenia, lo que incrementa el riesgo de enfermedad cardiovascular, más que la obesidad en sí. Objetivo: describir los hallazgos en la literatura científi ca sobre la asociación de la SO y los factores de riesgo y/o ECM (enfermedad cardiometabólica) o enfermedad cardiovascular (ECV). Métodos: se realizó una búsqueda electrónica en las siguientes bases de datos: MEDLINE, Scopus, SciELO, LILACS y Web of Science, usando las expresiones coincidentes y los operadores booleanos: "obesidad sarcopénica" o " sarcopénica obesidad ", en los títulos de los estudios, y "enfermedad cardiometabólica" o "enfermedad cardiovascular" o "síndrome metabólico" o "resistencia a la insulina", en el abstract. Resultados: la mayoría de los estudios son de corte transversales y presentan diferentes criterios de diagnóstico para la OS. Fue posible verifi car la asociación de la OS y los factores de riesgo y/o ECM o ECV. Conclusión: la OS está asociada con los factores de riesgo y/o ECM o ECV. La falta de un consenso sobre esta defi nición pone en peligro la efectividad de la práctica clínica y la investigación sobre el tema. AbstractIntroduction: The main changes in the body composition refer to the increase of adipose tissue and/or the decrease of muscular mass, and these changes have effect in many clinical outcomes. Sarcopenic obesity (SO) consists of the presence of excessive adipose tissue and defi cit of muscular mass simultaneously. People with SO may have synergistic effect due to obesity and sarcopenia, with increases cardiovascular risk more than obesity itself. Objective: To describe the fi ndings in the literature about the association between SO and risk factors and/or cardiometabolic disease (CMD) or cardiovascular disease (CVD). Methods: An electronic search was done on the following databases: MEDLINE, Scopus, SciELO, LILACS and Web of Science, using the matching expressions and Boolean operators: "obesity sarcopenic" OR "sarcopenic obesity", in the titles of the studies, AND "cardiometabolic disease" OR "cardiovascular disease" OR "metabolic syndrome" OR "insulin resistance", in the abstract. Results: Most of studies are cross-sectional and present many different diagnosis criteria for SO. It was possible to verify the association of the SO and the risk factors and/or CMD or CVD. Conclusion: SO is associated with risk factors and/or CMD or CVD. The lack of a consensus about this defi nition jeopardizes the effective clinical practice and the research about the subject.

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Section: Sarcopenic Obesity (Definition Diagnosis and Physiopathology)mentioning

confidence: 99%

Section: Sarcopenic Obesity (Definition Diagnosis and Physiopathology)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Association between sarcopenic obesity and cardiovascular risk: where are we?

Gusmão-Sena¹,

Curvello-Silva

Barreto-Medeiros

et al. 2016

Nutr Hosp

View full text Add to dashboard Cite

show abstract

“…AFAs (total area of abdominal fat, visceral fat, or subcutaneous fat) can also be assessed by computed tomography (CT) to examine independent associations between blood concentrations of FABP4 and BP from abdominal fat. A recent study demonstrated that serum concentrations of FABP were independently and positively associated with sarcopenic obesity as assessed by CT (16). However, a potential association between blood concentrations of FABP4 and abdominal fat in a general population by CT has not been assessed.…”

mentioning

confidence: 99%

Serum Fatty Acid Binding Protein 4 Concentrations Are Positively and Independently Associated with Blood Pressure and Abdominal Fat among Parameters in Health Check-Ups in Ordinary Middle-Aged Japanese Males

Yamada

Mochizuki

Honma

et al. 2015

J Nutr Sci Vitaminol

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SummaryWe wished to examine potential associations among blood concentrations of fatty acid-binding protein (FABP) 4 and parameters in health check-ups such as abdominal fat area (AFA) and blood pressure (BP) in middle-aged Japanese males. We conducted a cross-sectional study of males who participated in health check-ups in Japan. We excluded participants diagnosed with metabolic diseases by the time of their check-up. A total of 305 subjects (30-64 [mean6standard deviation, 47.368.5] y) were recruited. Areas of totalabdominal, visceral and subcutaneous fat were measured using computed tomography. We compared the association of serum concentrations of FABP4 with various clinical parameters by Pearson product-moment correlation coefficient (PPMCC) analyses, and by stepwise multivariate linear regression analyses (MLRA). PPMCC analyses showed that blood concentrations of FABP4 were positively associated with: body mass index; areas of fat (total abdominal, visceral, subcutaneous); systolic BP; diastolic BP; total cholesterol; low-density lipoprotein-cholesterol; triacylglycerol; activities of g-glutamyl transpeptidase, aspartate aminotransferase and alanine aminotransferase; white blood cell count; and levels of creatinine.Step-wise MLRA showed that AFAs (visceral and subcutaneous) and diastolic BP were positively and independently associated with serum concentrations of FABP4 among the parameters tested. These data suggest that serum concentrations of FABP4 are independently and positively associated with BP and AFA among parameters measured in health check-ups in middle-aged Japanese males.

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The Implications of Sarcopenia and Sarcopenic Obesity on Cardiometabolic Disease

Kim

Choi

2015

J of Cellular Biochemistry

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182

140

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The important changes in body composition associated with aging are a decline in skeletal muscle mass and an increase in body fat. Body fat distribution also changes with age; subcutaneous fat decreases and visceral abdominal fat increase, which contributes to numerous cardiometabolic diseases (CMDs) such as type 2 diabetes, dyslipidemia, and cardiovascular disease (CVD). Sarcopenia often accompanied by an increase in body fat and vice versa, a scenario termed sarcopenic obesity (SO), which might lead to the cumulative risk of both sarcopenia and obesity. However, there is still no consensus regarding the definition and consequences of SO. The lack of a unified definition for SO might contribute to inconsistent findings about the association of SO with CMD. Complex etiologies are associated with development of SO. A vicious cycle between the loss of muscle and the accumulation of ectopic fat might be associated with CMD via an intricate interplay of factors including proinflammatory cytokines, oxidative stress, mitochondrial dysfunction, insulin resistance, dietary energy, physical activity, mitochondrial dysfunction, and other factors that have yet to be identified. Moreover, recent epidemiological studies suggest that SO is related to CVD and mortality. This review focuses on the current literature with regard to the association between sarcopenia, dynapenia, and obesity, as well as their implications for CMD. The ultimate goal of this Prospects is to encourage conduct of well-designed future studies that elucidate the relationship among sarcopenia, SO, and CMD.

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Serum adipocyte fatty acid-binding protein levels are independently associated with sarcopenic obesity

Cited by 23 publications

References 38 publications

Association between sarcopenic obesity and cardiovascular risk: where are we?

Association between sarcopenic obesity and cardiovascular risk: where are we?

Serum Fatty Acid Binding Protein 4 Concentrations Are Positively and Independently Associated with Blood Pressure and Abdominal Fat among Parameters in Health Check-Ups in Ordinary Middle-Aged Japanese Males

The Implications of Sarcopenia and Sarcopenic Obesity on Cardiometabolic Disease

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