Serum adipocytokines are related to lipodystrophy and metabolic disorders in HIV-infected men under antiretroviral therapy

Abstract

These results suggest that adiponectin and the TNFalpha system are related to lipodystrophy, insulin resistance and metabolic alterations in patients under PI-based HAART. A/L and sTNFR1 could predict insulin sensitivity and potential cardiovascular risk in these patients.

Leptin inhibits apolipoprotein M transcription and secretion in human hepatoma cell line, HepG2 cells

“…In the present study, we further examined the effects of leptin on apoM synthesis in HepG2 Leptin is a cytokine-like peptide secreted by adipose tissue, known to regulate hepatic lipid and lipoprotein metabolism [12][13][14][15]. Mice with genetic defects in leptin exhibit hyperlipidemia, hyperinsulinemia, hyperglycemia and resistance to insulin [16][17][18].…”

Cardiovascular complications in the acquired immunodeficiency syndrome

“…Adipocytes secrete a range of adipocytokines which control insulin sensitivity 66 . There is evidence that an adipocytokine, adiponectin, a protein product of the apM1 gene, which is expressed exclusively in adipocytes, plays a role in development of HIV-associated lipodystrophy as well as in congenital and acquired lipodystrophies in non-HIV infected subjects 67 .…”

“…In vitro and animal studies and cross-sectional studies in humans have shown that adiponectin is inversely correlated with features of HAART-associated metabolic syndrome. This syndrome has recently been linked to a quantitative trait locus on chromosome 3q27, the location of the apM1 gene 66,68,69 . These studies have shown that both adiponectin levels and the adiponectin-to-leptin ratio are positively correlated with features of HAART-associated metabolic syndrome 66,68,69 .…”

“…This syndrome has recently been linked to a quantitative trait locus on chromosome 3q27, the location of the apM1 gene 66,68,69 . These studies have shown that both adiponectin levels and the adiponectin-to-leptin ratio are positively correlated with features of HAART-associated metabolic syndrome 66,68,69 . According to these studies, this ratio could be used to predict insulin sensitivity and potential cardiovascular risk in HIV-infected patients receiving HAART.…”

Association of the leptin to high-molecular-weight adiponectin ratio with metabolic syndrome

“…A combination of adiponectin and leptin as an index of insulin sensitivity was first proposed in 2003 [21]. Subsequently, many investigators have reported that the adiponectin/leptin ratio (or leptin/adiponectin ratio) is a relevant and reliable marker of insulin resistance in comparison with other parameters [20].…”