Serum adipokines and HIV viral replication in patients undergoing antiretroviral therapy

Aramă, Victoria; Tilişcan, Cătălin; Ion, Daniela Adriana; Mihăilescu, Raluca; Munteanu, Daniéla; Streinu‐Cercel, Anca; Tudor, Ana Maria; Hristea, Adriana; Leoveanu, Viorica; Olaru, Ioana D.; Aramă, Ștefan Sorin

doi:10.11599/germs.2012.1008

Cited by 6 publications

(5 citation statements)

References 22 publications

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“…This fungus survives even if the milk is treated at a temperature of 74°C for 15 seconds or at 64°C for 30 minutes, but complete destruction of the organism is possible when the milk is heated at 66°C for 30 minutes. Other fungal species such as Nocardia brasiliensis, Candida tropicalis, 35 Candida albicans 36 or Candida krusei 37 have also been shown to cause bovine mastitis and therefore can be transmitted to humans through incorrectly processed milk, posing a threat of fungal infection 38 particularly in immunodepressed patients (for example in case of diabetes, 39 HIV-positive patients with decreased CD4 count, [40][41][42][43][44] patients with cirrhosis 45 or with chronic alcohol consumption). 46…”

Section: Fungal Infectionsmentioning

confidence: 99%

Milk-borne infections. An analysis of their potential effect on the milk industry

Dhanashekar

Akkinepalli

Nellutla

2012

GERMS

107

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In developed countries such as the United States of America, foodborne illnesses account for 48 million infections per year. Developing countries such as India face greater simultaneous challenges particularly since incorrect processing or storage of dairy products can represent a transmission hazard for a large number of pathogens and can be responsible for outbreaks of brucellosis, listeriosis, tuberculosis, etc. It is important to recognize the types of germs which can be transmitted through insufficient thermal preparation of milk or milk products or through post-pasteurization contamination, in order to successfully avoid transmission of milk-borne infections.

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Section: Fungal Infectionsmentioning

confidence: 99%

Milk-borne infections. An analysis of their potential effect on the milk industry

Dhanashekar

Akkinepalli

Nellutla

2012

GERMS

107

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“…This test uses a mixture of 14 peptides representing ESAT-6, CFP-10 and a part of TB7.7. A recent study has compared QuantiFERON-TB Gold In-Tube, T-SPOT.TB and tuberculin skin test (TST) in 373 HIV-infected patients, 54,55 reporting that IGRAs were more sensitive than TST for the diagnosis of M tuberculosis infection in this category of patients. Ramos et al propose dual sequential testing with both TST and IGRAs as the optimal approach for latent tuberculosis infection screening in this population.…”

Section: Quantiferon-tb Gold In-tubementioning

confidence: 99%

Recent advances in the diagnosis of Mycobacterium tuberculosis

Anochie¹,

Onyeneke²,

Ogu³

et al. 2012

GERMS

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Molecular technologies offer the greatest potential for laboratories in resource-rich countries because they have the highest sensitivity and specificity.Continued use of new technologies will be crucial in elucidating the true epidemiology and pathogenesis of a disease, including the less well studied diseases.Continued development of affordable, sensitive, and specific diagnostic tools will be required for use in resource-poor settings, where the incidence of disease is highest.

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“…Given this unique background, and the patients’ history of over 20 years of HIV infection [3], we performed a study to check for renal impairment and bone demineralization in patients monitored for HIV infection in one Romanian HIV reference center in Bucharest [4], in order to design individualized therapeutic approaches and updated guidelines for screening and management in this particular patient population [5, 6]. …”

Section: Introductionmentioning

confidence: 99%

Prevalence of osteo-renal impairment in the Romanian HIV cohort

et al. 2016

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Background: The Romanian HIV cohort has certain particularities that render it unique in Europe. We have performed a study to evaluate the prevalence of bone and kidney impairment in this particular group of HIVinfected patients. Methods: We performed dual-energy X-ray absorptiometry (DXA) evaluation of the lumbar vertebrae and the femur, as well as laboratory tests including standard serum panels, bone-related markers and urinalysis in patients from the Romanian HIV cohort. Results: The study included 72 patients, of which 46 (58.3 %) were males. The median (IQR) age was 38 (18) years and the median (IQR) time from HIV infection diagnosis was 9 (13) years. Most patients (55.6 %) were non-smokers, but a relatively high proportion (37.5 %) was currently smoking. Only a small percentage of patients (20.8 %) did not present any comorbidities, while 40.3 % had one comorbidity, the most frequent being dyslipidemia (present in 25 patients, 38.5 %). Only 6 patients had a medical history suggestive for renal disease and 3 for bone-related abnormalities. The median (IQR) glomerular filtration rate was 97.5 (33.0) mL/min/1.73sqm. We diagnosed 21 patients (29.6 %) with stage 2 chronic kidney disease and one patient (1.4 %) with stage 3 chronic kidney disease. Proteinuria was present in 9 (12.7 %) patients. The estimated glomerular filtration rate was significantly lower in patients with cardiac comorbidities (p = 0.013). Vitamin D was significantly lower in smokers compared with non-smokers, with a mean value of 15 vs. 21 ng/mL and a moderate effect size (Cohen's d = −0.5) (p = 0.046). Lumbar osteopenia and osteoporosis were diagnosed in 33.3 and 13.7 % of patients, while femoral osteopenia and osteoporosis were diagnosed in 37.3 and 7.8 %, respectively. Lower nadir CD4 cell counts were found in patients with bone-related comorbidities (p = 0.000). Conclusions: We identified a relatively high prevalence of chronic kidney disease in the Romanian HIV cohort, and a fairly low prevalence of osteopenia and osteoporosis, compared with other European countries. In this category of patients smoking should be avoided altogether, as it may be an indirect risk factor for kidney disease (associating cardiac comorbidities) and it may impair bone metabolism by altering serum levels of hydroxy-vitamin D.

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Serum adipokines and HIV viral replication in patients undergoing antiretroviral therapy

Cited by 6 publications

References 22 publications

Milk-borne infections. An analysis of their potential effect on the milk industry

Milk-borne infections. An analysis of their potential effect on the milk industry

Recent advances in the diagnosis of Mycobacterium tuberculosis

Prevalence of osteo-renal impairment in the Romanian HIV cohort

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