Serum adiponectin and markers of endothelial injury in hemodialysis patients with arteriosclerosis obliterans

Saito, Osamu; Saitô, Takako; Okuda, Kousuke; Okuda, Kenji; Kotoda, Atsushi; Akimoto, Tetsu; Ando, Yumiko; Muto, Shigeaki; Ishikawa, San‐e; Kusano, Eiji

doi:10.1007/s10157-007-0012-7

Cited by 13 publications

(6 citation statements)

References 28 publications

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“…Although some studies [ 30 , 31 ] showed increased adiponectin level in patients with renal dysfunction but our study showed as the same of Shibata et al [ 32 ] that there is no association between adiponectin and renal function in atherosclerotic patients with normal renal function.…”

Section: Discussionsupporting

confidence: 53%

Is adiponectin associated with acute myocardial infarction in Iranian non obese patients?

2009

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Section: Discussionsupporting

confidence: 53%

Is adiponectin associated with acute myocardial infarction in Iranian non obese patients?

2009

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“…It has been shown that in hemodialysed patients, similarly to subjects with normal kidney function, lower plasma adiponectin concentrations are associated with cardiovascular complications: coronary artery disease or peripheral arterial occlusive disease (30,31). Similarly, plasma adiponectin concentration in peritoneal dialysis patients with carotid artery plaques was lower than in those without (32).…”

Section: Plasma Adiponectin Concentration and Vascular Pathology In Cmentioning

confidence: 99%

PROGRESS IN UREMIC TOXIN RESEARCH: Adiponectin in Patients with Chronic Kidney Disease

Adamczak

Chudek

Wiȩcek

2009

Seminars in Dialysis

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Adiponectin is one of many so called "adipokines"--cytokines, chemokines, growth factors, and complement proteins secreted by adipose tissue--that can affect the function of other organs. This antiatherogenic and insulin-sensitizing polypeptide is eliminated from the circulation mostly by the kidneys. Thus, in patients with chronic kidney disease, adiponectin accumulates in the circulation; its plasma concentration is approximately three times higher in end stage kidney disease than in healthy subjects. As no biological consequences of these unusually high adiponectin concentrations have been demonstrated, this polypeptide cannot be considered as a uremic toxin. On the contrary, inadequately low instead of high plasma adiponectin concentration is recognized as a new nontraditional risk factor of cardiovascular morbidity and mortality in these patients. This review summarizes the causes and clinical consequences of adiponectin accumulation in the circulation of patients with chronic kidney disease.

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“…Adiponectin levels have been found to be decreased in obesity and increased during weight loss; however, CKD has been associated with markedly elevated levels of adiponectin probably due to its decreased renal excretion [13,14]. Previously, it has been demonstrated that adiponectin has potential antiinflammatory and anti-atherogenic properties due to its modulatory effect on endothelial adhesion molecules acting as protective factor against atherogenesis [15].…”

Section: Introducionmentioning

confidence: 99%

Effect of Nutritional Status on Human Paraoxonase-1 Activity in Patients with Chronic Kidney Disease

Sztanek

Serés

Harangi

et al. 2012

Kidney Blood Press Res

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Background/Methods: The association between nutritional status, antioxidant human paraoxonase-1 (PON1) activity and low grade inflammation in hemodialized (HD) patients with chronic kidney disease (CKD) is unclear. The aim of this study was to determine PON1 paraoxonase and lactonase activities, ADMA, adiponectin and leptin concentrations, and to clarify the relationship between paraoxonase activity and a set of cardiovascular risk factors in malnourished, normal weight and obese HD patients; 114 HD patients with end-stage renal failure were enrolled. Results: Leptin levels were significantly higher and PON1 paraoxonase activities were significantly lower in obese patients compared to the other groups. Plasma adiponectin concentration was significantly lower in obese subjects compared to malnourished patients. Paraoxonase activity was negatively correlated with CRP level in HD and malnourished patients. Furthermore, we found significant inverse correlation between paraoxonase activity and BMI in the whole patient group. In multiple regression analysis, PON1 lactonase activity, CRP level and leptin concentration proved to be independent predictors of paraoxonase activity. Conclusion: Despite the previous findings of reverse epidemiology for the mortality rate of HD patients, further studies are needed to clarify the effects of nutritional state on atherosclerosis in obese and malnourished patients with end-stage renal failure.

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Serum adiponectin and markers of endothelial injury in hemodialysis patients with arteriosclerosis obliterans

Cited by 13 publications

References 28 publications

Is adiponectin associated with acute myocardial infarction in Iranian non obese patients?

Is adiponectin associated with acute myocardial infarction in Iranian non obese patients?

PROGRESS IN UREMIC TOXIN RESEARCH: Adiponectin in Patients with Chronic Kidney Disease

Effect of Nutritional Status on Human Paraoxonase-1 Activity in Patients with Chronic Kidney Disease

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