Serum Adiponectin Concentrations are not Related to Glycosylated Hemoglobin Levels (HbA1c) in Obese Diabetic and Non-diabetic Caucasians

Owecki, Maciej; Miczke, Anna; Pupek-Musialik, Danuta; Bryll, W.; Cymerys, Maciej; Nikisch, Elzbieta; Sowiński, Jerzy

doi:10.1055/s-2007-992116

Cited by 12 publications

(8 citation statements)

References 30 publications

(33 reference statements)

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“…One reason of this discrepancy may be physiological concentration in patients receiving insulin injection dose in our study. In addition, changes in glycaemia and HbA1c were not significantly associated with adiponectin and leptin, as previously reported [15,23,27,33]. These results suggest that adiponectin and leptin levels were primarily regulated by factors other than glycaemic control in type 2 diabetes.…”

Section: Discussionsupporting

confidence: 82%

Weight gain and changes in plasma adiponectin and leptin concentrations after 12-month insulin intensive therapy for Chinese male patients with newly diagnosed type 2 diabetes

Zhang

Zhao

Chen

et al. 2016

Obesity Research & Clinical Practice

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Section: Discussionsupporting

confidence: 82%

Weight gain and changes in plasma adiponectin and leptin concentrations after 12-month insulin intensive therapy for Chinese male patients with newly diagnosed type 2 diabetes

Zhang

Zhao

Chen

et al. 2016

Obesity Research & Clinical Practice

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“…Changes in adiponectin levels were not associated with improvement in metabolic control as assessed by fasting glucose and HbA1c. This lack of association between adiponectin and indices of diabetic control was also observed in earlier studies [34], although not in all [35]. Similarly, although we found a positive correlation of adiponectin with the gynoid depot and an inverse correlation with the android/gynoid ratio, we could not demonstrate a positive response of adipo-nectin levels to weight reduction.…”

Section: Discussionsupporting

confidence: 59%

Changes in adiponectin level and fat distribution in patients with type 2 diabetes

Miazgowski

Dziwura-Ogonowska

Safranow

et al. 2013

Eur J Clin Investigation

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“…On the other hand white Caucasians appear to be relatively protected from reduced adiponectin until they reach very high BMIs i.e. ≥35 [31]. Adiponectin is produced from subcutaneous and visceral adipocytes and the exact proportion of circulating adiponectin attributed to each depot is debated [32], [33].…”

Section: Discussionmentioning

confidence: 99%

Adipocyte Hypertrophy, Fatty Liver and Metabolic Risk Factors in South Asians: The Molecular Study of Health and Risk in Ethnic Groups (mol-SHARE)

et al. 2011

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ObjectiveWe sought to determine if differences in the distribution and characteristics of adipose tissue between South Asians and white Caucasians account for differences in risk factors for cardiovascular disease.Research Design and MethodsWe recruited 108 healthy South Asians (36.8 years) and white Caucasians (34.2 years) within three BMI strata. Body composition, adipocyte size, abdominal fat area, and hepatic adiposity were assessed and related to fasting glucose, insulin, lipids and adiponectin.ResultsAfter adjustment for age, sex, and BMI, South Asians compared to white Caucasians had higher ln fasting insulin (mean difference (md): 0.44; 95% CI: 0.20–0.69), lower HDL cholesterol (md: −0.13; 95% CI:−0.26 to −0.01), and lower adiponectin (md: −2.38; 95% CI: −3.59 to −1.17). South Asians also had more body fat (md: 2.69; 95% CI: 0.70 to 4.69), lower lean muscle mass (md: −3.25; 95%CI: −5.35 to −1.14), increased waist to hip ratio (md: 0.03; 95% CI: 0.01–0.05), less superficial subcutaneous abdominal adipose tissue (md: −2.94; 95% CI: −5.56 to−0.32), more deep/visceral to superficial adipose tissue ratio (md 0.34; 95% CI: 0.02 to 0.65), and more liver fat (md: 7.43%; 95% CI: 2.30 to 12.55%). Adipocyte area was increased in South Asians compared to white Caucasians (md: 64.26; 95% CI: 24.3 to 104.1) units2. Adjustment for adipocyte area attenuated the ethnic differences in insulin (md: 0.22; 95% CI: −0.07 to 0.51), HDL (md: −0.01; 95% CI: −0.16 to 0.13) and adiponectin (md: −1.11; 95% CI: −2.61 to 0.39). Adjustment for differences in adipocyte area and fat distribution attenuated the ethnic difference in liver fat (md: 5.19; 95% CI: 0.31 to 10.06).ConclusionSouth Asians have an increased adipocyte area compared to white Caucasians. This difference accounts for the ethnic differences in insulin, HDL cholesterol, adiponectin, and ectopic fat deposition in the liver.

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Serum Adiponectin Concentrations are not Related to Glycosylated Hemoglobin Levels (HbA1c) in Obese Diabetic and Non-diabetic Caucasians

Abstract: Concentrations of adiponectin were not correlated with levels of glycosylated hemoglobin in the diabetic and non-diabetic subjects examined.

Cited by 12 publications

References 30 publications

Weight gain and changes in plasma adiponectin and leptin concentrations after 12-month insulin intensive therapy for Chinese male patients with newly diagnosed type 2 diabetes

Weight gain and changes in plasma adiponectin and leptin concentrations after 12-month insulin intensive therapy for Chinese male patients with newly diagnosed type 2 diabetes

Changes in adiponectin level and fat distribution in patients with type 2 diabetes

Adipocyte Hypertrophy, Fatty Liver and Metabolic Risk Factors in South Asians: The Molecular Study of Health and Risk in Ethnic Groups (mol-SHARE)

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