Serum adiponectin correlates with viral characteristics but not histologic features in patients with chronic hepatitis C

Liu, Chun‐Jen; Chen, Pei‐Jer; Jeng, Yung‐Ming; Huang, Wen-Ling; Yang, Wei-Shiung; Lai, Ming-Yang; Kao, Jia‐Horng; Chen, Ding‐Shinn

doi:10.1016/j.jhep.2005.02.044

Cited by 65 publications

(68 citation statements)

References 50 publications

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“…In addition, adiponectin might have hepatic cytoprotective properties such as improving hepatic steatosis and injury in animal models of NAFLD [23]. Our recent data further showed that adiponectin may correlate with hepatitis C viral factors at both serum and liver tissue levels [24,25].…”

Section: Introductionmentioning

confidence: 79%

Metabolic profiles in patients with chronic hepatitis C: a case–control study

Hsu

Liu

et al. 2008

Hepatol Int

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BackgroundThe clinical implications of metabolic profiles in patients with chronic hepatitis C remain controversial. To study the association of metabolic abnormalities with chronic hepatitis C, we conducted a case-control study with special emphasis on serum lipid pattern, fasting blood glucose, and adiponectin. Methods We enrolled 500 patients with chronic hepatitis C and 536 sex and age-matched controls. Unadjusted and adjusted associations of demographic and metabolic variables were estimated. Results Chronic hepatitis C patients had higher alanine aminotransferase (ALT) and high-density lipoprotein-cholesterol levels, but lower total cholesterol (TC), triglyceride (TG), and low-density lipoprotein-cholesterol levels than controls. Stratifying ALT level according to its upper limit of normal, HCV infection was associated with younger age, female gender, and higher TC levels in chronic hepatitis C patients with normal ALT levels, but with lower TC and lower TG levels in those with abnormal ALT levels. By using multiple linear regression analyses for subjects with available adiponectin data, presence of HCV infection was independently associated with higher serum adiponectin levels. Conclusions Metabolic profiles of chronic hepatitis C patients are affected by age, gender, serum adiponectin, and ALT levels. Further longitudinal studies are needed to clarify the complex interplay between HCV infection and metabolic profiles.

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Section: Introductionmentioning

confidence: 79%

Metabolic profiles in patients with chronic hepatitis C: a case–control study

Hsu

Liu

et al. 2008

Hepatol Int

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“…The implications of adiponectin have been investigated extensively in patients with NAFLD [5,6,8] and limitedly in patients with chronic HVC infection [16]. However, the role of adiponectin in the development of HBV-related liver cirrhosis and HCC remains largely unknown.…”

Section: Discussionmentioning

confidence: 99%

“…Quantification of serum adiponectin level Serum adiponectin level was determined by a commercial ELISA assay (Human Adiponectin ELISA Kit, B-Bridge International, Inc., Mountain View, CA, USA) according to the manufacturer's instructions [16].…”

Section: Quantification and Genotyping Of Hbvmentioning

confidence: 99%

High serum adiponectin correlates with advanced liver disease in patients with chronic hepatitis B virus infection

et al. 2008

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Purpose Adiponectin possesses anti-inflammatory and insulin-sensitizing properties. Little is known about the role of adiponectin in hepatitis B-related liver disease.Methods Serum adiponectin and hepatitis B viral factors were cross-sectionally assayed in 280 patients with chronic hepatitis B virus (HBV) infection including 120 patients with chronic HBV infection, 40 patients with cirrhosis, and 120 patients with hepatocellular carcinoma (HCC); 116 healthy adults were used as controls. The dynamics of serum adiponectin level was also studied longitudinally in 25 patients with hepatitis B e antigen (HBeAg) seroconversion (SC). Results We found that serum adiponectin level in patients with chronic HBV infection was similar to that in healthy controls and was significantly lower than patients with cirrhosis and HCC. In univariate analysis, high serum adiponectin level significantly correlated with the presence of HBV-related cirrhosis or HCC, abnormal serum ALT level, and HBV genotype C. Multivariate analysis revealed that high serum adiponectin level significantly correlated with the development of HCC. Serum adiponectin levels remained stationary in patients experiencing HBeAg SC. Conclusions Our findings suggest that HBV infection itself does not affect adiponectin levels. Serum adiponectin level correlates with the progression of HBV-related liver diseases but not with the development of HBeAg SC.

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“…Es gibt also eine späte Phase, in der das Virus im Serum unter die Nachweisgrenze fallen kann. [4,10]. Wir selbst haben Polymorphismen im Exon 2 des Adiponektin-Gens untersucht und gefunden, dass Patienten mit einer chronischen Hepatitis C und Steatohepatitis mit Entzün-dungsgrad 3 bis 4 Polymorphismen in diesem Lokus aufweisen [13].…”

Section: Hepatitis Bunclassified

Aktuelle Probleme der Hepatitis

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Drebber

2008

Pathologe

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In den letzten Jahren hat sich das Bild der Virushepatitis, bedingt durch den raschen Fortschritt in der molekularen Virologie, erheblich geändert. Es wurden verschiedene neue Formen der Hepatitis heraus gearbeitet, die einer speziellen Diagnostik vor allem mit den modernen Mitteln der Molekularbiologie bedürfen, wobei diese auch am Paraffinmaterial der Biopsien angewendet werden können. Im Folgenden sollen die neuen Erkenntnisse auf dem Gebiet der Virushepatitiden B, C, D und E sowie bei Erkrankungen mit nichthepatotropen Viren, wie Epstein-Barr-Virus (EBV) und Zytomegalievirus (CMV), besprochen werden.Für die Diagnose der autoimmunen Hepatitis wurden kürzlich neue Kriterien vorgeschlagen, die hier kurz eingeführt und kommentiert werden. Hepatitis BDer natürliche Verlauf der chronischen Hepatitis B wird inzwischen besser verstanden, weil die modernen molekularbiologischen Methoden noch einzelne Virusgenome nachweisen können und das Schicksal des Virus im Organismus inzwischen so beschrieben wird, dass mit dem Fortgang der Erkrankung die Menge an replizierenden Viren allmählich und kontinuierlich abnimmt. Es gibt also eine späte Phase, in der das Virus im Serum unter die Nachweisgrenze fallen kann.

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Serum adiponectin correlates with viral characteristics but not histologic features in patients with chronic hepatitis C

Cited by 65 publications

References 50 publications

Metabolic profiles in patients with chronic hepatitis C: a case–control study

Metabolic profiles in patients with chronic hepatitis C: a case–control study

High serum adiponectin correlates with advanced liver disease in patients with chronic hepatitis B virus infection

Aktuelle Probleme der Hepatitis

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