Serum Adiponectin Levels are Inversely Correlated with Insulin Resistance in Obese Men with Type 2 Diabetes

Izadi, Morteza; Goodarzi, Mohammad Taghi; Khalaj, Hamidreza Samari; Davood, Khorshidi; Hossein, Doali

doi:10.5812/kowsar.1726913x.1966

Cited by 11 publications

(3 citation statements)

References 28 publications

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“…Insulin resistance is also inversely correlated with serum adiponectin, as anti-inflammatory cytokines, in type II diabetic patients (18). The prevalence of obesity in patients with type 2 diabetes mellitus has been reported in both developed and developing country (19). The change in TNF-α expression in adipose tissue is directly related to the rate of obesity and hyperinsulinemia levels (20,21).…”

Section: Discussionmentioning

confidence: 99%

The Effect of Regular Aerobic Training on Tumor Necrosis Factor-Alpha (TNF-α) in Males With Type II Diabetes

Ghasemalipour¹,

Eizadi²,

Hajirasouli³

2015

Avicenna J Med Biochem

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Background: A growing body of literature suggests that systemic inflammation is associated with obesity, type II diabetes and metabolic syndrome. Objectives: The aim of this study was to evaluate the effect of three months of aerobic training on serum Tumor Necrosis Factor-alpha (TNF-α), as an inflammatory cytokine, in males with type II diabetes. Patients and Methods: Twenty-four adult obese males aged 38 to 48 years and Body Mass Index (BMI) of 30 to 36 kg/m 2 with type II diabetes were randomly divided to exercise (n = 12) and control (n = 12) groups. The exercise group completed an aerobic training program (for three months, three times/week) and the control group did not participate in the exercise program. Fasting serum TNF-α and all anthropometrical markers were measured before and after the training program. Data was analyzed by independent-paired sample T test. Results: Exercise training resulted in a significant increase in body weight (P < 0.001), body fat percentage (P < 0.001), BMI (P < 0.001) and abdominal circumference (P < 0.001). There was no significant difference in serum TNF-a before-compared to after-training program (P = 0.83). Conclusions: Based on these data, we conclude that the aerobic training program does not have an anti-inflammatory property with emphasis on serum TNF-α in type II diabetic patients.

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Section: Discussionmentioning

confidence: 99%

The Effect of Regular Aerobic Training on Tumor Necrosis Factor-Alpha (TNF-α) in Males With Type II Diabetes

Ghasemalipour¹,

Eizadi²,

Hajirasouli³

2015

Avicenna J Med Biochem

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“…This protein plays a major role in the regulation of serum triglycerides (TG) level via interaction with ANGPTL-3 and -4 (6,8), as well as lipoprotein lipase blocking; therefore, ANGPTL-8 increases TG level (9). It is noted that dyslipidemia is a characteristic of T2D and insulin resistance; the high level of TG, cholesterol, and low-density lipoprotein as ordinary facets of dyslipidemia is reported in T2D (10,11). This protein, as a hepatokine (12), is associated with hepatocellular lipid content (13).…”

Section: Introductionmentioning

confidence: 99%

A Short Review on ANGPTL-8 as an Important Regulator in Diabetes

Esfahani

Goodarzi

2019

Avicenna J Med Biochem

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ANGPTL8, a new hormone, is regarded as a novel target for type-2 diabetes and associated metabolic disorder. Nutritional state and hormonal factors are involved in the regulation of ANGPTL-8 expression. This protein is associated with some myokines or adipokines. Several studies confirmed the function of ANGPTL-8 in glucose metabolism and diabetes complications; however, there are opposite results. The accurate function of ANGPTL-8 in T2D remains unclear. Further strictly controlled studies including measuring methods, nutritional state, diagnostic criteria of overweight/obesity, age, and ethnicity may help to resolve discrepancies. In addition, more studies are demanded to clarify the potential role of ANGPTL-8 in humans, a cause or an effect of this protein in association with insulin resistance, the regulatory mechanism of ANGPTL-8 expression, and the association of ANGPTL8 with other adipokines or myokines. In this mini review, we described various roles of ANGPTL-8 in diabetes.

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“…Other important factors in obesity-related T2DM are the release of pro-inflammatory cytokines by adipocytes; however their pathological role in inducing insulin resistance and diabetes is unclear. Both fasting plasma levels of TNF-α and dysregulation of interleukin-6 activity are associated with increased insulin resistance and T2DM (41).…”

mentioning

confidence: 99%

Obesity-linked diabetes in the Arab world: a review

Abuyassin¹,

Laher²

2015

East Mediterr Health J

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The Arab world is experiencing an epidemic of obesity and type 2 diabetes mellitus. This review summarizes the major pathological factors linking obesity to diabetes, focussing on current epidemiological data related to obese diabetic patients in the Arab world, the etiology of the disease and the genetic determinants of diabetes and obesity. There are alarming data related to the rising prevalence of obesity and type 2 diabetes mellitus in children of Arab ethnicity. Replication studies identify several genetic variants in Arabs with obesitylinked diabetes. For example, variants of the ADIPOQ gene (the rs266729 single-nucleotide polymorphism) are associated with obesity and diabetes in various Arab countries. Gaps exist in our information about diabetes and obesity in Arab populations in relation to ethnic-specific cut-off points for diagnosis and treatment of diabetes. Further genome-wide association studies in obese and diabetic Arab populations could add to our understanding of the pathophysiology, prevention and reversal of this disease.

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Serum Adiponectin Levels are Inversely Correlated with Insulin Resistance in Obese Men with Type 2 Diabetes

Cited by 11 publications

References 28 publications

The Effect of Regular Aerobic Training on Tumor Necrosis Factor-Alpha (TNF-α) in Males With Type II Diabetes

The Effect of Regular Aerobic Training on Tumor Necrosis Factor-Alpha (TNF-α) in Males With Type II Diabetes

A Short Review on ANGPTL-8 as an Important Regulator in Diabetes

Obesity-linked diabetes in the Arab world: a review

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