Serum agouti-related protein (AgRP) levels in bipolar disorder: Could AgRP be a state marker for mania?

Blood levels of agouti-related peptide (AgRP), obestatin, corticosteroid-binding globulin (CBG), and cortisol in patients with bipolar disorder (BD): a case–control study

“…This might be explained by documented data about indifference in AgRP levels between obese and nonobese schizophrenic patients [17,31]. In contrast to our results, Parlak et al reported significant lower serum levels of AgRP in manic non-obese patients than euthymic and control group, and attributed it to impaired energy homeostasis [14]. The different results may be attributed to the weight status of the patients and actual period of the disease.…”

“…AgRP is a powerful orexigenic neuropeptide, elevation in which leads to hyperphagia and obesity [11], but its role in the development of obesity in BD is undefined. Parlak et al reported a significant lower AgRP levels in manic patients, and linked it to impaired homeostasis [14]. In addition to its orexigenic effect, it is defined as a powerful modulator of energy balance.…”

“…The role of AgRP in schizophrenia obesity treated with antipsychotics has been investigated in a few studies [12,13]. However, its role in BD obesity has not previously been investigated but it is implicated to have a role in impaired energy homeostasis during manic episode [14]. Since during manic episode AgRP levels are reported to be higher than euthymic patients and controls, AgRP is suggested to be a state marker for manic episodes.…”

“…To the best of our knowledge, there are studies present that relate adipokine levels with BD, but only one study is present with regard to AgRP levels in BD [14]. This study was designed to investigate various sociodemographic characteristics and biochemical parameters including serum levels of AgRP, obestatin, CBG, and total cortisol in patients with BD.…”

The Relationship Between Eating-Attitudes and Clinical Characteristics, Agouti-Related Peptide, and Other Biochemical Markers in Adult-Attention Deficit Hyperactivity Disorder

“…It has been reported in the literature that AgRP, which functions as an orexigenic neuropeptide, regulates energy metabolism by increasing appetite and decreasing energy consumption, leads to weight gain by increasing food intake, and maybe a candidate gene for obesity ((Ilnytska & Argyropoulos, 2008; Shen et al, 2002). Serum AgRP levels were found to be significantly lower in patients with manic episodes compared to euthymic and control groups, and it was suggested that this might be an indicator of impaired energy homeostasis during manic episodes (Parlak et al, 2018). In our study, it was observed that serum AgRP levels of patients who did not receive methylphenidate treatment were lower than those of healthy volunteers, but they did not reach statistical significance.…”