Serum Alanine Transaminase Is an Inadequate Nonalcoholic Fatty Liver Screening Test in Adolescents: Results From the National Health and Nutrition Examination Survey 2017-2018

Abrams, Gary A.; Rabil, Anna; Williams, Ana-Ysabel P; Hecht, Eric M.

doi:10.1177/00099228211020177

Cited by 5 publications

(4 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, some researchers have presented contrasting results. For instance, Abrams et al proposed that serum ALT levels were not an adequate screening tool to detect NAFLD [30].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Analysis of risk factors for fatty liver disease in children with Wilson’s disease

Jia,

Wang,

Tao

et al. 2024

European Journal of Gastroenterology &Amp; Hepatology

View full text Add to dashboard Cite

Background and aims Many children with Wilson’s disease are complicated with dyslipidemia. The aim of this study was to investigate the risk factors for the development of fatty liver disease (FLD) in children with Wilson’s disease. Methods We evaluated sex, age, weight, the disease course, treatment course, clinical classification, alanine transaminase (ALT), aspartate transaminase, γ-glutamyl transpeptidase, total biliary acid, triglyceride, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, homocysteine, uric acid, fibrinogen (FBG), creatinine, procollagen III N-terminal propeptide, laminin, hyaluronic acid, type IV collagen, and performed receiver operating characteristic curve analysis to investigate the forecast value of individual biochemical predictors and combined predictive indicators to evaluate FLD in Wilson’s disease. Results The multivariate logistic regression analysis revealed that ALT [odds ratio (OR), 1.011; 95% confidence interval (CI), 1.004–1.02; P = 0.006], uric acid (OR, 1.01; 95% CI, 1.002–1.018; P = 0.017), FBG (OR, 3.668; 95% CI, 1.145–13.71; P = 0.037), creatinine (OR, 0.872; 95% CI, 0.81–0.925; P < 0.001), and laminin (OR, 1.01; 95% CI, 1.002–1.018; P = 0.017) acted as independent risk factors in Wilson’s disease complicated with FLD. The receiver operating characteristic curves for combined predictive indicators demonstrated an area under the curve values of 0.872, which was found to be a significant predictors for FLD in Wilson’s disease. Conclusions We screened out the most important risk factors, namely ALT, uric acid, creatinine, FBG, and laminin for Wilson’s disease complicated with FLD. The joint prediction achieved is crucial for identifying children with Wilson’s disease complicated with FLD.

show abstract

“…However, some researchers have presented contrasting results. For instance, Abrams et al proposed that serum ALT levels were not an adequate screening tool to detect NAFLD [30].…”

Section: Discussionmentioning

confidence: 99%

“…For instance, Abrams et al . proposed that serum ALT levels were not an adequate screening tool to detect NAFLD [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Analysis of risk factors for fatty liver disease in children with Wilson’s disease

Jia,

Wang,

Tao

et al. 2024

European Journal of Gastroenterology &Amp; Hepatology

View full text Add to dashboard Cite

show abstract

“…In 2017, the American Academy of Pediatrics (AAP) issued guidelines that recommended using serum alanine transaminase (ALT), aware of its limitations, to screen for NAFL and NAFLD 9 . However, recent studies, have demonstrated the poor diagnostic sensitivity of serum ALT for identifying adolescents with NAFL or NAFLD 10,11 . Therefore, there are limited clinically useful parameters by which to determine who should be screened for NAFL and NAFLD.…”

Section: Introductionmentioning

confidence: 99%

“…9 However, recent studies, have demonstrated the poor diagnostic sensitivity of serum ALT for identifying adolescents with NAFL or NAFLD. 10,11 Therefore, there are limited clinically useful parameters by which to determine who should be screened for NAFL and NAFLD.…”

mentioning

confidence: 99%

Risk stratification of adolescents for the screening of non‐alcoholic fatty liver disease

et al. 2022

Self Cite

View full text Add to dashboard Cite

Background: Non-alcoholic fatty liver conditions in adolescence are associated with premature mortality in adulthood. Effective screening could impact the population burden of this disease.Objectives: We sought to determine which adolescents should be screened for nonalcoholic fatty liver using vibration-controlled transient elastography. Methods: We simulated a non-alcoholic fatty liver screening program of 938 adolescents from the National Health and Nutritional Examination Survey of 2017/2018.We stratified subjects by body mass index and metabolic parameters and analyzed our data using standard diagnostic statistical measures. Results:The weighted prevalence of non-alcoholic fatty liver and non-alcoholic fatty liver disease was 24.4%, and 3.8%, respectively. For all subjects with obesity (21.8% of the population), screening identified 61.8% of the non-alcoholic fatty liver cases.In a category of all subjects with obesity and overweight subjects with metabolic abnormalities (26.7% of the population), screening identified 71.2% of non-alcoholic fatty liver cases. Conclusions:The two groups most likely to benefit by transient elastography screening are adolescents with obesity and overweight adolescents with one metabolic abnormality. These criteria reduce the number of individuals to be tested by approximately 80% (from an approximate 32 million adolescents to 6-7.5 million adolescents), while retaining a diagnostic accuracy of 84%-85%.

show abstract

NAFLD, the hepatic manifestation of the metabolic syndrome

Chaudhury,

Brodosi,

Marchesini

et al. 2024

Metabolic Syndrome

View full text Add to dashboard Cite

Serum Alanine Transaminase Is an Inadequate Nonalcoholic Fatty Liver Screening Test in Adolescents: Results From the National Health and Nutrition Examination Survey 2017-2018

Cited by 5 publications

References 15 publications

Analysis of risk factors for fatty liver disease in children with Wilson’s disease

Analysis of risk factors for fatty liver disease in children with Wilson’s disease

Risk stratification of adolescents for the screening of non‐alcoholic fatty liver disease

NAFLD, the hepatic manifestation of the metabolic syndrome

Contact Info

Product

Resources

About