Serum albumin: clinical significance of drug binding and development as drug delivery vehicle

Tayyab, Saad; Feroz, Shevin Rizal

doi:10.1016/bs.apcsb.2020.08.003

Cited by 61 publications

(26 citation statements)

References 81 publications

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“…The mechanism of low serum albumin leading to poor tumor prognosis is complex. For example, low serum albumin level could impair the body’s natural defense mechanisms [ 25 ], reduce the efficiency of treatment options [ 26 ], as well as delayed recovery and increased mortality [ 27 ]. Various blood examination-based nutritional parameters have been implicated in tumor prognosis (prognostic nutritional index [ 28 ], albumin-globulin ratio [ 29 ] and c-reactive protein to albumin ratio [ 30 ]).…”

Section: Discussionmentioning

confidence: 99%

Advanced lung cancer inflammation index (ALI) predicts prognosis of patients with gastric cancer after surgical resection

et al. 2022

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Introduction Advanced lung cancer inflammation index (ALI) has been implicated in the prognosis of many types of tumors. But few studies elucidate its role in gastric cancer (GC). Materials and methods We consecutively recruited 615 GC patients who underwent radical gastrectomy. Patients were grouped according to ALI status. Risk factors for overall survival (OS) and disease-free survival (DFS) in overall and sex-stratified cohorts were determined using multivariate cox regression analysis. We also compared survival differences between the two groups after one-to-one propensity score matching (PSM). Results Patients with low ALI showed larger tumor size, more advanced TNM staging, shorter OS (median: 37 vs 42 months) and DFS (median: 37 vs 42 months) (all P < 0.001). Multivariate analysis showed that elevated ALI was independently associated with longer OS and DFS. After stratification by sex, low ALI was an independent risk factor for OS and DFS in male patients but not in female patients. But our further PSM analysis showed prognostic value of ALI in both male and female subgroups. Conclusion Preoperative ALI is an independent prognostic factor for GC patients undergoing curative gastrectomy.

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Section: Discussionmentioning

confidence: 99%

Advanced lung cancer inflammation index (ALI) predicts prognosis of patients with gastric cancer after surgical resection

et al. 2022

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“…A better knowledge of mycolactone interaction with serum carriers is thus essential for the therapeutic use of mycolactone. Many studies report efforts to develop drug delivery systems using albumin or HDLs as a drug carriers ( Wasan et al, 2008 ; Larsen et al, 2016 ; Hoogenboezem and Duvall, 2018 ; Tayyab et al, 2021 ). Accumulation of albumin in solid tumors as well as overexpression of SR-B1 in most malignancies warrant developing carrier-based drug delivery systems for tumor targeting ( Larsen et al, 2016 ; Raut et al, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

Molecular Mechanisms Underpinning the Circulation and Cellular Uptake of Mycobacterium ulcerans Toxin Mycolactone

et al. 2021

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Mycolactone is a diffusible lipid toxin produced by Mycobacterium ulcerans, the causative agent of Buruli ulcer disease. Altough bacterially derived mycolactone has been shown to traffic from cutaneous foci of infection to the bloodstream, the mechanisms underpinning its access to systemic circulation and import by host cells remain largely unknown. Using biophysical and cell-based approaches, we demonstrate that mycolactone specific association to serum albumin and lipoproteins is necessary for its solubilization and is a major mechanism to regulate its bioavailability. We also demonstrate that Scavenger Receptor (SR)-B1 contributes to the cellular uptake of mycolactone. Overall, we suggest a new mechanism of transport and cell entry, challenging the dogma that the toxin enters host cells via passive diffusion.

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“…Whereas a low binding affinity suggests immediate availability of the administered compound, a high binding affinity infers that HSA may function as a reservoir maintaining homogeneous distribution to the tissues thereby increasing biological lifetimes [45]. Considering its role on overall drug pharmacokinetics [46], HSA may limit and/or control toxicity while modulating metabolic inactivation and elimination through excretory pathways. A secondary yet equally relevant objective underlying initial assessment of HSA binding properties is to identify predominant molecular species in the compound mixture and determine an average molecular weight.…”

Section: Experimental Strategymentioning

confidence: 99%

Characterization of Aurintricarboxylic Acid (ATA) Interactions with Plasma Transporter Protein and SARS-CoV-2 Viral Targets: Correlation of Functional Activity and Binding Energetics

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Hashimoto

et al. 2022

Life

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In an effort to identify functional-energetic correlations leading to the development of efficient anti-SARS-CoV-2 therapeutic agents, we have designed synthetic analogs of aurintricarboxylic acid (ATA), a heterogeneous polymeric mixture of structurally related linear homologs known to exhibit a host of biological properties, including antiviral activity. These derivatives are evaluated for their ability to interact with a plasma transporter protein (human serum albumin), eukaryotic (yeast) ribosomes, and a SARS-CoV-2 target, the RNA-dependent RNA polymerase (RdRp). The resultant data are critical for characterizing drug distribution, bioavailability, and effective inhibition of host and viral targets. Promising lead compounds are selected on the basis of their binding energetics which have been characterized and correlated with functional activities as assessed by inhibition of RNA replication and protein synthesis. Our results reveal that the activity of heterogeneous ATA is mimicked by linear compounds of defined molecular weight, with a dichlorohexamer salicylic-acid derivative exhibiting the highest potency. These findings are instrumental for optimizing the design of structurally defined ATA analogs that fulfill the requirements of an antiviral drug with respect to bioavailability, homogeneity, and potency, thereby expanding the arsenal of therapeutic regimens that are currently available to address the urgent need for effective SARS-CoV-2 treatment strategies.

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Serum albumin: clinical significance of drug binding and development as drug delivery vehicle

Cited by 61 publications

References 81 publications

Advanced lung cancer inflammation index (ALI) predicts prognosis of patients with gastric cancer after surgical resection

Advanced lung cancer inflammation index (ALI) predicts prognosis of patients with gastric cancer after surgical resection

Molecular Mechanisms Underpinning the Circulation and Cellular Uptake of Mycobacterium ulcerans Toxin Mycolactone

Characterization of Aurintricarboxylic Acid (ATA) Interactions with Plasma Transporter Protein and SARS-CoV-2 Viral Targets: Correlation of Functional Activity and Binding Energetics

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