Serum albumin in Hodgkin's disease

Gobbi, Paolo G.; Gendarini, A; Crema, A.; Cavalli, C.; Attardo-Parrinello, Giuseppe; Fédérico, Massimo; Prisco, Ubaldo Di; Ascari, E

doi:10.1002/1097-0142(19850115)55:2<389::aid-cncr2820550216>3.0.co;2-f

Cited by 26 publications

(10 citation statements)

References 7 publications

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“…Hemoglobin level and serum albumin level were also known prognostic factors for lymphoma [29, 30]. This relationship was also observed on the univariate analysis of this study.…”

Section: Discussionsupporting

confidence: 80%

Mitoxantrone, etoposide, cytarabine, and melphalan (NEAM) followed by autologous stem cell transplantation for patients with chemosensitive aggressive non‐Hodgkin lymphoma

Kim

Lee

et al. 2012

American J Hematol

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Patients with chemosensitive aggressive non‐Hodgkin lymphoma (NHL) could benefit from high‐dose chemotherapy (HDC) followed by autologous stem cell transplantation (auto‐SCT). We report clinical outcomes of HDC using a novel regimen consisting of mitoxantrone, etoposide, cytarabine, and melphalan (NEAM) with auto‐SCT. A total of 69 patients were consecutively enrolled. Median age was 42 years (range, 20–66 years). Median event‐free survival (EFS) was 17.9 months. Median overall survival (OS) has not been reached yet and estimated 2‐year OS was 64.2%. Among patients with measurable lesions, response rate was 79.5%. Median time to recovery of neutrophil (>500 mL) and platelet (gt;20,000 mL) was 12.5 and 13.5 days, respectively. Febrile neutropenia developed in 61 patients (88.4%). Grades 3 or 4 hepatic toxicity developed in 7 patients (10.1%), Grades 3 or 4 renal toxicity in 2 patients (2.9%), and Grade 3 or 4 cardiac toxicity in 2 patients (2.9%). Transplant‐related mortality (TRM) developed in two patients (2.9%). Multiple prior treatments before transplantation, auxiliary bone marrow harvest for stem cell collection, and high serum lactate dehydrogenase level were related to unfavorable treatment outcomes. In conclusion, NEAM conditioning with auto‐SCT demonstrated considerable efficacy with modest toxicity in patients with chemosensitive aggressive NHL. Am. J. Hematol. 87:479–483, 2012. © 2012 Wiley Periodicals, Inc.

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“…Hemoglobin level and serum albumin level were also known prognostic factors for lymphoma [29, 30]. This relationship was also observed on the univariate analysis of this study.…”

Section: Discussionsupporting

confidence: 80%

Mitoxantrone, etoposide, cytarabine, and melphalan (NEAM) followed by autologous stem cell transplantation for patients with chemosensitive aggressive non‐Hodgkin lymphoma

Kim

Lee

et al. 2012

American J Hematol

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“…Age and sex frequently influence the outcome of Hodgkin's lymphoma, and the disseminating potential of the dis-ease is noted by stage IV. Inflammatory processes and effects driven by cytokine release are reflected by serum albumin 17,18,53,54 and hemoglobin 14,[16][17][18]20,55,56 levels, as well as by abnormalities of white-cell counts (leukocytosis 49 and lymphocytopenia 14,40,50,57,58 ).…”

Section: Discussionmentioning

confidence: 99%

A Prognostic Score for Advanced Hodgkin's Disease

Hasenclever

Diehl

Armitage³

et al. 1998

N Engl J Med

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373

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“…The concentration of paraproteins, increased in multiple myeloma, is easy to identify in serum protein electrophoresis (16,17). Significant changes in serum protein fractions were observed in lymphoma (18), leukemia (19), Hodgkin's disease (20) and breast cancer (21,22). In the present investigation, the electrophoretic pattern of serum proteins in different types of cancer patients was studied by agarose gel electrophoresis to find out if there is a specific protein pattern in neoplasia.…”

Section: Introductionmentioning

confidence: 99%

Serum proteins profile as an indicator of malignancy: multivariate logistic regression and ROC analyses

Rasouli¹,

Okhovatian²,

Enderami³

2005

Clinical Chemistry and Laboratory Medicine (CCLM)

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The electrophoretic pattern of serum proteins of 85 patients carrying different types of neoplasia and 85 matched healthy adults were comparatively studied by agarose gel electrophoresis, to find out if there is a specific protein pattern common to different types of cancer. Each protein fraction was analyzed quantitatively by densitometry. Multivariate logistic regression and receiver operating characteristic (ROC) analyses were performed using SPSS software. When total protein and albumin were measured by colorimetric methods, cancer patients, compared to controls, had a decreased concentration of total protein (66.0+/-11.5 g/L vs. 76.4+/-6.8 g/L, p< or =0.0001) and of albumin (39.0+/-8.1 g/L vs. 46.0+/-4.3 g/L, p< or =0.0001). The electrophoretic data of serum proteins showed that the ratio of albumin to globulin (0.92+/-0.30 vs. 1.21+/-0.16, p< or =0.0001), percent of the fractions albumin (46.7+/-8.5% vs. 54.4+/-3.5%, p< or =0.0001) and beta-globulin (11.6+/-4.4% vs. 13.0+/-1.9%, p< or =0.001) were decreased and alpha(1)- (5.3+/-2.5% vs. 2.9+/-0.8%, p< or =0.0001), alpha(2)- (13.5+/-4.8% vs. 11.3+/-2.1%, p< or =0.0001) and gamma-globulins (23.0+/-7.7% vs. 18.3+/-3.1%, p< or =0.0001) were significantly increased in cancer patients relative to controls. Cancer patients also had higher counts of leukocytes (7.98+/-3.11, x10(9) cells/L vs. 6.33+/-1.68 x10(9) cells/L, p< or =0.0001) and erythrocyte sedimentation rate (35.9+/-23.5 mm/h vs. 14.1+/-9.5 mm/h,p< / =0.0001). On the basis of univariate analysis, a protein profile out of the normal ranges was more prevalent in cancer patients than in controls. Analysis of the data using multiple logistic regression indicated that the prevalence of cancer was strongly associated with the serum proteins' profile, and alpha(1)-globulin, erythrocyte sedimentation rate, total protein and the ratio of albumin to globulin were the best parameters to discriminate between malignant and healthy states. The area under the ROC curves were the same for most components of the serum proteins' profile at about 0.75+/-0.09, p< or =0.001. We conclude that the profile of serum proteins indicates high diagnostic values for discriminating between cancer patients and healthy individuals and may be useful as an adjunct diagnosis for detection of malignancy.

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Serum albumin in Hodgkin's disease

Cited by 26 publications

References 7 publications

Mitoxantrone, etoposide, cytarabine, and melphalan (NEAM) followed by autologous stem cell transplantation for patients with chemosensitive aggressive non‐Hodgkin lymphoma

Mitoxantrone, etoposide, cytarabine, and melphalan (NEAM) followed by autologous stem cell transplantation for patients with chemosensitive aggressive non‐Hodgkin lymphoma

A Prognostic Score for Advanced Hodgkin's Disease

Serum proteins profile as an indicator of malignancy: multivariate logistic regression and ROC analyses

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