Serum Albumin Level as a Predictor of Outcome in Patients Admitted to Pediatric Intensive Care Units

Bekhit, Osama E.; Yousef, Remon M.; AbdelRasol, Hoiyda A.; Mohammed, Mohammed A.

doi:10.1097/pec.0000000000002567

Cited by 9 publications

(8 citation statements)

References 32 publications

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“…It has been demonstrated that increasing the serum ALB is an effective means of reducing the mortality rate of patients. 30 , 31 …”

Section: Discussionmentioning

confidence: 99%

Microbiological Analysis and Mortality Risk Factors in Patients with Polymicrobial Bloodstream Infections

Xu¹,

Yuan²,

Wang³

et al. 2023

IDR

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Purpose To study the etiological characteristics and risk factors affecting the prognosis of patients with polymicrobial bloodstream infections. Patients and Methods Overall, 141 patients with polymicrobial bloodstream infections in Henan Provincial People’s Hospital during 2021 were included. Laboratory test indexes, department of admission, sex, age, intensive care unit (ICU) admission, surgical history, and central venous catheter placement were collected. Patients were divided into surviving and deceased groups based on outcomes at discharge. Mortality risk factors were identified by univariate and multivariable analyses. Results Seventy-two of 141 patients survived. Patients were mainly from the ICU and the Departments of Hepatobiliary Surgery and Hematology. Overall, 312 microbial strains were detected: 119 gram-positive, 152 gram-negative, and 13 anaerobic bacteria and 28 fungi. Among the gram-positive bacteria, coagulase-negative staphylococci were most frequent (44/119, 37%), followed by enterococci (35/119, 29.4%). Among coagulase-negative staphylococci, methicillin-resistant coagulase-negative staphylococci incidence was 75% (33/44). Among gram-negative bacteria, Klebsiella pneumoniae was most common (45/152, 29.6%), followed by Escherichia coli (25/152, 16.4%) and Pseudomonas aeruginosa (13/152, 8.6%). Among K. pneumoniae , the incidence of carbapenem-resistant (CR) K. pneumoniae was 45.7% (21/45). On univariate analysis, mortality risk factors included increased white blood cells and C-reactive protein, decreased total protein and albumin, CR strains, ICU admission, central venous catheter, multiple organ failure, sepsis, shock, pulmonary diseases, respiratory failure, central nervous system diseases, cardiovascular diseases, hypoproteinemia, and electrolyte disturbances (P < 0.05). Multivariable analysis showed that ICU admission, shock, electrolyte disorders, and central nervous system diseases were independent mortality risk factors. The survival curve shows that the survival rate of patients with polymicrobial CR bloodstream infections was lower than that of patients with polymicrobial non-CR bloodstream infections (P=0.029). Conclusion Patients with polymicrobial bloodstream infections are typically critically ill and harbor multidrug-resistant bacteria. Thus, to minimize mortality rate in critically ill patients, changes in infectious flora should be monitored, antibiotics selected reasonably, and invasive procedures reduced.

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“…It has been demonstrated that increasing the serum ALB is an effective means of reducing the mortality rate of patients. 30 , 31 …”

Section: Discussionmentioning

confidence: 99%

Microbiological Analysis and Mortality Risk Factors in Patients with Polymicrobial Bloodstream Infections

Xu¹,

Yuan²,

Wang³

et al. 2023

IDR

View full text Add to dashboard Cite

show abstract

“…In a large prospective study, a decrease in albumin levels of 25 g/L was associated with an increase in morbidity of 55%. Consistently, albumin concentrations have also been shown to be associated with poor clinical outcomes in critically ill children ( 2 , 14 ). Each increase of 10 g/L in serum albumin in critically ill children is associated with a 73% reduction in the risk of 60-day mortality (hazard ratio = 0.27; 95% CI: 0.14–0.51) ( 2 ).…”

Section: Discussionmentioning

confidence: 87%

“…Each increase of 10 g/L in serum albumin in critically ill children is associated with a 73% reduction in the risk of 60-day mortality (hazard ratio = 0.27; 95% CI: 0.14–0.51) ( 2 ). In a recent study, albumin levels still showed a negative association with mortality in patients admitted to the PICU (OR = 0.289; 95% CI: 0.136–0.615) ( 14 ).…”

Section: Discussionmentioning

confidence: 99%

U-shaped association between serum albumin and pediatric intensive care unit mortality in critically ill children

Zhang

Wei

et al. 2022

Front. Nutr.

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IntroductionThe detailed association between albumin levels and mortality has not been studied in critically ill children. The aim of this study was to reveal an association between albumin levels in detail and mortality in critically ill children.Materials and methodsWe retrospectively collected data from children admitted to four pediatric intensive care units (PICUs) in China between January 2015 and October 2020. Restricted cubic spline curves based on logistic regression models were generated to evaluate the detailed associations between serum albumin levels and PICU mortality. Threshold effect analysis was performed using two piecewise regression models.ResultsThe study included 9,123 children. The overall mortality was 5.3%. The detailed association between serum albumin levels and the risk of mortality followed a U-shape. The risk of mortality decreased with increasing serum albumin levels (OR = 0.919; 95% CI: 0.886, 0.954) in children with serum albumin levels < 43.2 g/L and increased with increasing serum albumin levels (OR = 1.174; 95% CI: 1.044, 1.316) in children with serum albumin levels ≥ 43.2 g/L.ConclusionThere was a U-shaped association between serum albumin levels and mortality in critically ill children in the PICU.

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“…Literature reported that low serum albumin level was associated to poor outcomes in critically ill patients [12,13]. Also, in children with nephrotic syndrome serum albumin level < 1.5gm/dl was found to be an independent risk factor for all types of infection [14].…”

Section: Introductionmentioning

confidence: 95%

Serum albumin level as predictor of infection in children with nephrotic syndrome age 2- 18years in northwest and East Amhara region, Ethiopia: a multi-center cross-sectional retrospective study

Mekonnen,

Alene,

Yimer

et al. 2024

Preprint

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Background Infection is the most common complication of pediatric patients with nephrotic syndrome. The factors associated with infection in nephrotic syndrome are lacking in the setting where this research was done. This study aimed to identify the prevalence and associated factors among children with nephrotic syndrome aged 2 to 18 years. Methods A hospital based retrospective cross-sectional study was conducted. An Epi5 collector electronic data collector installed with a smartphone was used to collect the data. The collected data was exported to Stata version 15.1 for analysis. Descriptive findings like mean, standard deviation and percentage were reported. Logistic regression was used to identify the factors associated with infection. Results In this study, the prevalence of infection among nephrotic syndrome children is 39.8% (95%CI: 30.7, 49.7). The types of infection identified were pneumonia, urinary tract infection, diarrheal disease, cutaneous fungal infection, intestinal parasitic infection, and sepsis. Serum albumin level, hematuria, and residence were significantly associated with infection. Conclusions The presence of hematuria predicted the presence of infection in nephrotic syndrome in children. Increasing the level of serum albumin decreased the likelihood of infection in children with nephrotic syndrome. Further study is recommended to strengthen this finding.

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Serum Albumin Level as a Predictor of Outcome in Patients Admitted to Pediatric Intensive Care Units

Cited by 9 publications

References 32 publications

Microbiological Analysis and Mortality Risk Factors in Patients with Polymicrobial Bloodstream Infections

Microbiological Analysis and Mortality Risk Factors in Patients with Polymicrobial Bloodstream Infections

U-shaped association between serum albumin and pediatric intensive care unit mortality in critically ill children

Serum albumin level as predictor of infection in children with nephrotic syndrome age 2- 18years in northwest and East Amhara region, Ethiopia: a multi-center cross-sectional retrospective study

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