Serum albumin levels in ischemic stroke and its subtypes: Correlation with clinical outcome

Serum Albumin and High-Sensitivity C-reactive Protein are Independent Risk Factors of Chronic Kidney Disease in Middle-Aged Japanese Individuals: the Circulatory Risk in Communities Study

“…In addition, serum albumin acts as an extracellular antioxidant by inhibiting the formation of oxidized LDL-cholesterol 23) and by binding and thus preventing the toxic effects of free fatty acids in the serum 24) . Accordingly, low serum albumin levels have been associated with the risks of myocardial infarction, atrial fibrillation, cardiovascular disease, and death 25–28) .…”

Serum albumin level is associated with the recurrence of acute ischemic stroke

“…Low albumin level has been shown to be capable to predict the severity of ischemic stroke for follow-up at 30 days [18] and 3 months [10]. Several studies in different populations found that serum albumin level had a negative correlation with stroke severity [8,11]. To the best of our knowledge, few researchers have investigated the correlation of albumin level with stroke recurrence.…”

“…In addition, albumin also has been reported to reduce the hematocrit value, block the erythrocyte aggregation, and decrease the erythrocyte sedimentation rate [4,30,31]. Serum albumin is conducive to sustaining neuronal metabolism by increasing the export of pyruvate to neurons after entering the brain under pathologic conditions [8]. Belayev et al [32] found that delayed high-concentration albumin therapy initiated 2 to 4 hours after stroke onset of transient focal ischemia in rats had beneficial effects.…”

“…Several studies have demonstrated the obvious protective influence of serum albumin in many diseases, such as myocardial infarction and cardiovascular diseases [7][8][9]. In recent years, some studies have showed a neuroprotective effect of serum albumin in ischemic stroke on animal models.…”

Albumin impact on clinical practice and complications of ischemic stroke in patients with stroke

“…Babu MS and et al in a study showed that higher rate of serum albumin in ischemia stroke decrease from bad prognosis of disease. 12 According to the Chkaraborty and et al study rate of albumin has significant relation with increasing severity of disease and long bad prognosis of diseases. 13 Yuko and et al showed that higher doses of albumin therapy may have neuroprotective effects on ischemic stroke.…”