Serum alkaline phosphatase and urinary hydroxyproline values in children receiving phenobarbital with and without vitamin D

Liakakos, D; Papadopoulos, Zeta; Vlachos, P; Boviatsi, Ecaterini; Varonos, D.

doi:10.1016/s0022-3476(75)80605-6

Cited by 26 publications

(7 citation statements)

References 21 publications

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“…Previously, AP levels have been found to be elevated in patients receiving a number of drugs 8 ; in pediatrics, the use of anticonvulsants and trimethoprimsulfamethoxazole have been associated with increased AP levels. [9][10][11] Children with infections and/or those with a history of weight loss have also been found to have elevated AP levels. 11 In our unselected population of children, there was no statistical association between either recent illness or medication use and elevated AP levels.…”

Section: Discussionmentioning

confidence: 99%

“…7 However, increased AP levels have also been reported in children with a variety of other diseases and in patients receiving a number of drugs, including anticonvulsants and antibiotics. [8][9][10] In addition, elevations of AP levels that are 3 to 50 times normal values have been reported in young children without other evidence of illness, including bone or liver diseases. [11][12][13][14] This condition, termed transient hyperphosphatasemia of infancy and childhood, occurs primarily in children younger than 5 years old.…”

Section: Introductionmentioning

confidence: 99%

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The Utility of Alkaline Phosphatase Measurement as a Screening Test for Rickets in Breast-fed Infants and Toddlers: A Study From the Puget Sound Pediatric Research Network

Taylor

Richter²,

Done

et al. 2010

Clin Pediatr (Phila)

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To determine if alkaline phosphatase (AP) levels are a useful screening test for rickets, the authors measured serum AP levels in children 6 to 15 months old who were predominantly breast-fed for > 6 months without vitamin D supplementation. Radiographs were obtained on children with elevated AP levels to determine the presence of rickets. AP levels were obtained on 246 children; levels were elevated in 33 (13.4%). Rickets was present in 4 of 18 children with elevated levels on whom radiographs were obtained. The sensitivity and specificity of AP levels as a test for rickets was maximal at a cutoff value of 552 U/L. Using this cutoff value, the specificity of AP levels as a test for rickets was 97.4%, and the positive predictive value (PPV) was 40.0%. These results suggest that AP levels may be a useful screening test for rickets in children who are breast-fed for prolonged periods without vitamin D supplementation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Utility of Alkaline Phosphatase Measurement as a Screening Test for Rickets in Breast-fed Infants and Toddlers: A Study From the Puget Sound Pediatric Research Network

Taylor

Richter²,

Done

et al. 2010

Clin Pediatr (Phila)

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“…In this retrospective study, we identified at least six cases among 227 patients with either a kidney or liver Tx. Some cases have been reported with failure to thrive (3) and the role of some drugs has been suggested to increase ALP activity (6, 14, 15). It has also been reported that patients suffering from leukemia and lymphoma have increased ALP activity (16, 17), without any proven link to the primary disease.…”

Section: Discussionmentioning

confidence: 99%

Transient hyperphosphatasemia after organ transplantation in children

Ranchin

Villard

André

et al. 2002

Pediatric Transplantation

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Transient, isolated hyperphosphatasemia is a rare, benign condition of childhood. Few cases have been described in transplant patients. We report six cases: three after liver transplantation and three after kidney transplantation. Such a phenomenon was found to be as benign after organ transplantation as it is in healthy children. Hence, an isolated increase in the serum alkaline phosphatase level following transplantation should not be of concern in this population of patients.

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“…In surveys of large groups of epileptic patients the frequent occurrence of hypocalcemia, raised alkaline phosphatase, and radiological rickets has been observed (Richens and Rowe, 1970;Hunter et al, 1971;Sontaniemi et al, 1972;Lifshitz and Maclaren, 1973;Crosley et al, 1975;Tol-man et al, 1975), and several studies reported reduced serum 25-hydroxyvitamin D levels (Hahn et al, 1972~;Baud et al, 1974;Bouillon et al, 1975;Mosekilde et al, 1977). Some investigators suggested that supplementary vitamin D should be given to patients on chronic antiepileptic treatment, but estimations of the dosage required ranged from 12.5 pg to 100 pg vitamin D per day (Hahn et al, 1972~;Maclaren and Lifshitz, 1973;Bouillon et al, 1975;Christiansen et al, 1975a,b;Hahn and Avioli, 1975;Liakakos et al, 1975;Berger et al, 1976;Peterson et al, 1976).…”

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confidence: 99%

Antiepileptic Drugs and Vitamin D Supplementation

1979

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The incidence of biochemical signs of vitamin D deficiency and the effects of vitamin D supplementation were investigated in 83 children and 95 adults on chronic antiepileptic therapy and 40 mentally retarded controls living under comparable conditions. Low 25-hydroxyvitamin D and serum calcium, and elevated immunoreactive parathyroid hormone and alkaline phosphatase was a common finding in all groups, but in patients on antiepileptic drugs, signs of vitamin D deficiency were recorded more frequently. Supplementation of 125 microgram or 250 microgram vitamin D3 per week for 9 months normalized the laboratory findings in most patients; the effect of 37.5 microgram/week only slightly exceeded the influences of season observed in the controls and in epileptic patients without vitamin D. It is suggested that a dose between 37.5 and 125 microgram vitamin D3/week might be most suitable to avoid biochemical signs of vitamin D deficiency in children and adults on antiepileptic drugs.

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Serum alkaline phosphatase and urinary hydroxyproline values in children receiving phenobarbital with and without vitamin D

Cited by 26 publications

References 21 publications

The Utility of Alkaline Phosphatase Measurement as a Screening Test for Rickets in Breast-fed Infants and Toddlers: A Study From the Puget Sound Pediatric Research Network

The Utility of Alkaline Phosphatase Measurement as a Screening Test for Rickets in Breast-fed Infants and Toddlers: A Study From the Puget Sound Pediatric Research Network

Transient hyperphosphatasemia after organ transplantation in children

Antiepileptic Drugs and Vitamin D Supplementation

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