Serum alkaline phosphatase in diabetes mellitus.

Maxwell, D B; Fisher, Edward A.; rd, H A Ross-Clunis; Estep, Herschel L.

doi:10.1080/07315724.1986.10720112

Cited by 34 publications

(23 citation statements)

References 20 publications

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“…Osteocalcin is also a marker of bone turnover, when bone formation and resorption are coupled [25]. An increase in serum alkaline-phosphatase, derived from bone, is frequently found in diabetic patients [26,27], but in the present study serum leucine amino peptidase also decreased after glycemic control. It is not concluded that the decrease in serum total alkaline-phosphatase was due to the change in its iso-enzyme from bone.…”

Section: Discussioncontrasting

confidence: 28%

Effect of Glycemic Control on Calcium and Phosphorus Handling and Parathyroid Hormone Level in Patients with Non-Insulin-Dependent Diabetes Mellitus.

et al. 1995

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Section: Discussioncontrasting

confidence: 28%

Effect of Glycemic Control on Calcium and Phosphorus Handling and Parathyroid Hormone Level in Patients with Non-Insulin-Dependent Diabetes Mellitus.

et al. 1995

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“…[56] Both ALP and phosphate levels are more effective in predicting the risk of total mortality of people with diabetes and cardiovascular diseases. It is reported that 38% of diabetic patients have elevated serum alkaline phosphatase levels, mean fasting serum glucose level is positively associated with ALP, and bone ALP is the predominant type, which may be caused by diabetic bone diseases [57]. Indeed 9 out of 15 studies on the association of phosphate level with total mortality have shown an ascending incidence of diabetes in higher categories of phosphate (data now shown).…”

Section: Discussionmentioning

confidence: 90%

Can Serum Levels of Alkaline Phosphatase and Phosphate Predict Cardiovascular Diseases and Total Mortality in Individuals with Preserved Renal Function? A Systemic Review and Meta-Analysis

Cui

Fan

et al. 2014

PLoS ONE

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BackgroundIt is demonstrated that elevated serum levels of alkaline phosphatase (ALP) and phosphate indicate a higher risks of cardiovascular disease (CVD) and total mortality in population with chronic kidney disease (CKD), but it remains unclear whether this association exists in people with normal or preserved renal function.MethodClinical trials were searched from Embase and PubMed from inception to 2013 December using the keywords “ALP”, “phosphate”, “CVD”, “mortality” and so on, and finally 24 trials with a total of 147634 patients were included in this study. Dose-response and semi-parametric meta-analyses were performed.ResultsA linear association of serum levels of ALP and phosphate with risks of coronary heart disease (CHD) events, CVD events and deaths was identified. The relative risk(RR)of ALP for CVD deaths was 1.02 (95% confidence interval [CI], 1.01–1.04). The RR of phosphate for CVD deaths and events was 1.05 (95% CI, 1.02–1.09) and 1.04 (95% CI: 1.03–1.06), respectively. A non-linear association of ALP and phosphate with total mortality was identified. Compared with the reference category of ALP and phosphate, the pooled RR of ALP for total mortality was 1.57 (95% CI, 1.27–1.95) for the high ALP group, while the RR of phosphate for total mortality was 1.33 (95% CI, 1.21–1.46) for the high phosphate group. It was observed in subgroup analysis that higher levels of serum ALP and phosphate seemed to indicate a higher mortality rate in diabetic patients and those having previous CVD. The higher total mortality rate was more obvious in the men and Asians with high ALP.ConclusionA non-linear relationship exists between serum levels of ALP and phosphate and risk of total mortality. There appears to be a positive association of serum levels of ALP/phosphate with total mortality in people with normal or preserved renal function, while the relationship between ALP and CVD is still ambiguous.

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“…Heazell et al 2006 reported a case of pregnancy complicated by gestational diabetes and hypertension in which extremely high elevation of bone specific isoenzyme of alkaline phosphatase was noted during labour this lead to elevation in total serum alkaline phosphatase which couldn’t be assume to arise from placenta. [5354]…”

Section: Discussionmentioning

confidence: 99%

A study of bone turnover markers in gestational diabetes mellitus

Siddiqi

Borse

Pervez

et al. 2017

Indian J Endocr Metab

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Introduction:Gestational diabetes is defined as carbohydrate intolerance resulting in hyperglycemia of variable severity with the first recognition during pregnancy. Established risk factors for gestational diabetes mellitus (GDM) are maternal age, obesity, family history of diabetes, etc. Vitamin D, parathyroid hormone (PTH), and various other hormones are known for their function in maintaining calcium and phosphorous homeostatic. Furthermore, Vitamin D, PTH serum ionized calcium, and alkaline phosphatase (ALP) have been reported to be altered with glucose homeostasis. The present study compares the bone markers in pregnant women with and without gestational diabetes.Materials and Methods:This cross-sectional study was conducted at outpatient antenatal check-up clinic and outpatient diabetic clinics at J. N. Medical College and Hospital, Aligarh. One hundred pregnant females, of which fifty with GDM and fifty without GDM, were included in the study from January 2014 to November 2015. Detailed history, physical examination, and anthropometric measurement were done. Bone turnover markers in the form of Vitamin D, parathyroid hormone, serum ionized calcium, and serum ALP were measured in pregnant women who had gestational diabetes which was compared with normal pregnant women.Results:In our study, the mean age of participate of GDM group was 28.2 ± 3 years, while the mean age group in non-GDM group was 25.44 ± 2.78 years. Ionized calcium in GDM was found to be 4.606 ± 0.354 mEq/L, while in non-GDM, it was 4.548 ± 0.384 mEq/L, P = 0.430. Vitamin D came out to be 21.80 ± 9.48 ng/ml, while it was 32.346 ± 8.37 ng/ml in non-GDM group. Serum PTH in GDM group was 71.436 ± 36.189 pg/ml and 37.168 ± 8.128 pg/ml in nondiabetic gestational group. Serum ALP in GDM group was 9.1 ± 4.56 KA U/dl and 6.98 ± 2.2 KA U/dl in nondiabetic gestational group, P - 0.0038. In GDM group, there was a significant negative linear correlation between PTH and 25-hydroxyvitamin D with research correlation coefficient r = −0.9073, P = 0; there was a significant positive linear correlation coefficient between PTH and ALP with Persian correlation coefficient r = 0.6597, P = 0; there was no statistically significant correlation between PTH and ionized calcium r = 0.1416, P = 0.3267.Conclusion:All GDM subjects should ideally be screened for serum calcium, vitamin D, PTH, ALP. If found impaired should immediately be corrected in order to prevent its adverse effects on maternal and fetal outcome. Vitamin D supplementation should ideally be initiated in all GDM females even if the above parameters are not investigated in Indian setup.

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Serum alkaline phosphatase in diabetes mellitus.

Cited by 34 publications

References 20 publications

Effect of Glycemic Control on Calcium and Phosphorus Handling and Parathyroid Hormone Level in Patients with Non-Insulin-Dependent Diabetes Mellitus.

Effect of Glycemic Control on Calcium and Phosphorus Handling and Parathyroid Hormone Level in Patients with Non-Insulin-Dependent Diabetes Mellitus.

Can Serum Levels of Alkaline Phosphatase and Phosphate Predict Cardiovascular Diseases and Total Mortality in Individuals with Preserved Renal Function? A Systemic Review and Meta-Analysis

A study of bone turnover markers in gestational diabetes mellitus

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