Serum Amino Acid Levels and Mortality in Patients Undergoing Percutaneous Endoscopic Gastrostomy

Sivritepe, Rıdvan; Basat, Sema; Gökmen, Neslihan

doi:10.29271/jcpsp.2021.11.1278

J Coll Physicians Surg Pak

2021

DOI: 10.29271/jcpsp.2021.11.1278

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Serum Amino Acid Levels and Mortality in Patients Undergoing Percutaneous Endoscopic Gastrostomy

Rıdvan Sivritepe

Sema Basat

Neslihan Gökmen

Abstract: Objective: To evaluate the effect of feeding via percutaneous endoscopic gastrostomy tube (PEG) on serum amino acid levels and mortality.

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2024

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Could Urinary Amino Acids Be as New Biomarkers for Detection of Sarcopenia?

Sivritepe,

Basat,

Gökmen

et al. 2024

Preprint

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Background Sarcopenia is one of the syndromes that cause falls, fractures, and morbidity in geriatric patients. Early diagnosis of sarcopenia is important as it is known that muscle functions improve with early intervention. We aimed to investigate whether urinary amino acid levels are a biomarker of sarcopenia. Methods The study included ninety-one patients aged 45–65 who applied to our outpatient clinic. The patients underwent physical examinations, blood tests and sixteen different urine amino acid levels were analyzed. Anthropometric measurements were made. Physical performances were evaluated. Muscle strengths were measured. Muscle masses were analyzed. Patients were divided into 4 groups: pre-sarcopenic, sarcopenic, severe sarcopenic and non-sarcopenic. Statistical significance level was determined as p < 0.05. Results A total of ninety-one patients, fifty-three female and thirty-eight males, were included in the study. Three patients had pre-sarcopenia, eleven had sarcopenia, and two met the criteria for severe sarcopenia, while seventy-five patients were non sarcopenic. A significant difference was found between the sarcopenia and non-sarcopenia groups in terms of glutamine and valine levels (p < 0.001 for both). In the ROC analysis, the cut-off value of glutamine and valine levels in detecting sarcopenia was determined as 492 micromole/L and 209 micromole/L (AUC:0.875;0.968 respectively). In correlation analysis between urine amino acid levels and muscle strength-mass a negative correlation was found between leucine and muscle strength and muscle mass. Conclusions We found that patients with sarcopenia had high urinary glutamine and valine levels and that urinary leucine levels were associated with both muscle strength and muscle mass.

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Could Urinary Amino Acids Be as New Biomarkers for Detection of Sarcopenia?

Sivritepe,

Basat,

Gökmen

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

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Serum Amino Acid Levels and Mortality in Patients Undergoing Percutaneous Endoscopic Gastrostomy

Abstract: Objective: To evaluate the effect of feeding via percutaneous endoscopic gastrostomy tube (PEG) on serum amino acid levels and mortality.

Cited by 1 publication

References 4 publications

Could Urinary Amino Acids Be as New Biomarkers for Detection of Sarcopenia?

Could Urinary Amino Acids Be as New Biomarkers for Detection of Sarcopenia?

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