Serum amylase and lipase values in acute renal failure.

Zachée, Pierre; Lins, R.L.; Broe, Marc E. De

doi:10.1093/clinchem/31.7.1237

Cited by 14 publications

(8 citation statements)

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“…12 Berk et al 13 indicated that hyperamylasemia was found in 50% of their uremic patients, and fewer than three times the URL. Hyperlipasemia was reported by Sommer et al 14 in 46% and by Zachee et al 15 in 65% of their patients. Jiang et al 2 in their study on patients with ESRD found high levels of SA and SL in 60.7% and 57.1%, respectively.…”

Section: Discussionmentioning

confidence: 77%

Pancreatic Enzymes in End-stage Renal Disease Patients on Maintenance Hemodialysis

Aatif¹,

Akka²

2018

Indian Journal of Medical Biochemistry

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Background: Elevated serum levels of pancreatic enzymes are frequently observed in end-stage renal disease (ESRD) in the absence of pancreatic diseases. Aim: Evaluate the prevalence of elevated pancreatic enzymes in patients on maintenance hemodialysis (HD) and compare it with healthy controls. Materials and methods: Serum amylase (SA) and serum lipase (SL) levels were evaluated in 20 patients on maintenance HD (group I) and compared with levels in 25 healthy controls (group II). Results: In group I, hyperamylasemia and/or hyperlipasemia were found in 14 (70%) patients. Abnormal levels of both SA and SL simultaneously were noted in 7 (35%); however, hyperamylasemia and hyperlipasemia only were noted, respectively, in 11 (55%) and in 10 (50%) patients. There was a significant moderate positive correlation between SA and serum creatinine (103.8 ± 50.6 vs 89.9 ± 20.9; r = 0.48; p = 0.029), and between SL and serum creatinine (61.2 ± 40.1 vs 89.9 ± 20.9; r = 0.47; p = 0.034) in group I. Mean SA values were significantly higher in group I in comparison with group II: 103.8 ± 50.6 vs 64.1 ± 31.5 U/L; p = 0.005, and mean SL values were significantly higher in group I in comparison with group II: 61.2 ± 40.1 vs 31.8 ± 17.7 U/L; p = 0.002. Conclusion:Our results indicate that elevated serum levels of pancreatic enzymes in ESRD patients on maintenance HD is slight but frequently occurs. There is a general agreement that reduced glomerular filtration rate would be the cause. The occurrence of hypothetical concomitant pancreatic damage has been suggested and the complex hemodynamic, biochemical, and physiological alterations in uremia were speculated to cause an excessive release of pancreatic enzymes.

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Section: Discussionmentioning

confidence: 77%

Pancreatic Enzymes in End-stage Renal Disease Patients on Maintenance Hemodialysis

Aatif¹,

Akka²

2018

Indian Journal of Medical Biochemistry

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“…Pancreas amylase, lipase, and trypsin are sensitive and specific parameters for which reliable assays are known. Nevertheless, determinations of amylase and lipase show some limitations: Hyperamylasemia presents not only in pancreatic disease but also in other pathologic situations like parotitis, mumps, renal insufficiency, or macroamylasemia (225)(226)(227)(228)(229). Urinary measurement of amylase is not specific and is no longer encouraged.…”

Section: Analytes Of Clinical Interestmentioning

confidence: 99%

Clinical chemistry

Stinshoff¹,

Stein²,

Wood³

et al. 1987

Anal. Chem.

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“…Amylase and lipase are both filtered at the glomerulus, however no increase was observed in AKI in this study. Elevations in amylase concentrations have however been described by others in the context of AKI in patients with no clinical evidence of pancreatitis [ 13 ]. Of these analytes, only a fall in serum creatinine >40% was associated with median reductions in amylase more than the RCV.…”

Section: Discussionmentioning

confidence: 99%