Serum amyloid A and haptoglobin concentrations in relation to growth and colostrum intake in neonatal lambs

Peetsalu, Kristel; Tummeleht, Lea; Kuks, Ants; Orro, Toomas

doi:10.1016/j.livsci.2019.01.002

Cited by 7 publications

(14 citation statements)

References 21 publications

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“…However, only a few studies have analysed the APPs in sheep (Arslan, Cenesiz, Nisbet, & Yazici, ; Dow, Rogers‐Niemana, Holáskováa, Elsasserb, & Daileya, ; Melling, Bårdsen, & Ulvund, ; Miglio et al, , ; Peetsalu, Tummeleht, Kuks, & Orro, ; Yang et al, ). The APPs have been estimated in neonatal lambs (Peetsalu et al, ), during the pregnancy of ewes, but only in the first six weeks of pregnancy (Dow et al, ), in the period from 60 to 140 days of pregnancy and postpartum, and during the three‐month period of lactation (Miglio et al, ) therefore, they have not been determined strictly in the periparturient period. The major APPs in ewes are SAA, Hp and fibrinogen (Fb); these concentrations are usually very low but increase markedly in the course of subclinical inflammation and may have important diagnostic value as early markers of subclinical diseases involving acute inflammation (Jain, Gautam, & Naseem, ).…”

Section: Introductionmentioning

confidence: 99%

“…Reference values of serum haptoglobin (Hp) and serum amyloid A (SAA) have been determined for pigs, horses, ponies, camels, cows and goats. However, only a few studies have analysed the APPs in sheep (Arslan, Cenesiz, Nisbet, & Yazici, 2007;Dow, Rogers-Niemana, Holáskováa, Elsasserb, & Daileya, 2010;Melling, Bårdsen, & Ulvund, 2012;Miglio et al, 2015Miglio et al, , 2018Peetsalu, Tummeleht, Kuks, & Orro, 2019;Yang et al, 2018).…”

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confidence: 99%

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Acute‐phase proteins, cortisol and haematological parameters in ewes during the periparturient period

Greguła-Kania

Kosior-Korzecka

Patkowski

et al. 2020

Reprod Domestic Animals

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Numerous subclinical diseases in sheep occur in the periparturient period and involve inflammatory processes; therefore, determining markers, such as acute‐phase proteins (APPs), can allow an early diagnosis. Therefore, the objective of the present study was to assess changes in the plasma concentration of APPs and cortisol in clinically healthy ewes in the periparturient period for use in future studies. At the same time, haematological parameters were monitored. We showed that plasma APPs and cortisol concentrations were significantly higher in pregnant ewes than before insemination. A gradual increase in the SAA concentration was observed from the 14th day before to the day of parturition, while Hp was reduced from 2 weeks before up to 2 weeks after delivery. A significant increase in the Fb concentration was detected from the 14th day before to the 1st week after delivery. The cortisol concentration did not undergo significant changes in the periparturient period. We found an increase in the SAA and Fb concentrations and decrease in Hp in the periparturient period. The direction of the change in APPs of healthy ewes in the current study may be related to their distinct regulatory mechanisms during pregnancy. The APPs are usually altered during infection, inflammation, neoplasia, stress and trauma; therefore, knowing their reference values could help lead to an early diagnosis of subclinical forms of some diseases and pregnancy complications in ewes. The haematological analysis showed that ewes in late pregnancy and postpartum compared to dry period were under metabolic stress related to pregnancy and lactation.

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%

Acute‐phase proteins, cortisol and haematological parameters in ewes during the periparturient period

Greguła-Kania

Kosior-Korzecka

Patkowski

et al. 2020

Reprod Domestic Animals

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“…A proteomic study in sheep demonstrated colostrum led to higher SAA concentrations in lambs (Hernández-Castellano et al, 2014). In our previous study, we found positive associations between colostrum SAA and lamb serum SAA at 1 to 5 d of age, which indicates the important effect of ewe's colostrum on lambs (Peetsalu et al, 2019).…”

Section: Introductionmentioning

confidence: 53%

“…In calves, it has been shown that colostrum SAA isoforms do not directly cross calf intestines (Orro et al, 2008). Our previous studies demonstrated that ewe colostrum SAA and lamb serum SAA were positively associated during the first 5 d of life, and we hypothesized that colostrum has a direct influence on the systemic innate immune response of lambs (Niine et al, 2018a;Peetsalu et al, 2019). The present study did not confirm this hypothesis, but because lambs, in contrast to calves, have ad libitum access to colostrum, the colostrum effect may be different in these 2 species.…”

Section: Discussionmentioning

confidence: 93%

“…The concentrations of different APP change during the first few weeks of ruminant life and are termed age-related changes in APP. In lambs and goat kids, SAA concentrations increase during the first week of life, start to decrease during the second week, and then stabilize at the end of the third week (Eckersall et al, 2008;Ulutas et al, 2017;Niine et al, 2018a;Peetsalu et al, 2019;Dinler et al, 2020). It has been suggested that colostrum intake influences the APP concentration in calves, as their SAA concentrations were found to be low before colostrum consumption and then increased during the first 24 h after birth (Orro et al, 2008;Tóthová et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

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Effect of colostrum on the acute-phase response in neonatal dairy calves

Peetsalu

Niine

Loch

et al. 2022

Journal of Dairy Science

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The core part of the mammal innate immune system is the acute-phase response (APR), during which acutephase proteins (APP) are synthesized. Colostrum contains immunomodulating factors such as proinflammatory cytokines and APP in large quantities. We looked at proinflammatory cytokines [IL-1β, IL-6, and tumor necrosis factor-α (TNF-α)] and APP [serum amyloid A (SAA) and haptoglobin (Hp)] in colostrum and in calves' serum. The aim of this study was to evaluate the effects of colostrum on the calves' systemic APR and the associations of the calves' serum APR with short-and long-term weight gain (at the age of 1, 3, and 9 mo). A total of 143 female dairy calves were studied during their first 3 wk of life. The calves were separated from their mothers immediately after birth and bottle-fed 3 L of quality-controlled colostrum once within 2 h after birth. Serum samples were collected once a week during the first 3 wk of life (a total of 1-3 samples per calf). Mean sampling age (±standard deviation) was 4.3 (±2.0) d in the first week, 11.0 (±2.0) d in the second week, and 18.0 (±2.0) d in the third week. Linear regression models were used to study associations of colostrum APP and cytokine concentration with serum APR markers and for studying associations of colostrum and serum APR markers with calves' average daily weight gain (ADWG). Mixed linear regression models were used to compare serum concentrations of APR markers by study weeks. The colostrum IL-6 concentrations were positively associated with serum IL-6 in the first 3 wk of life. Colostrum IL-1β was positively associated with calves' serum IL-1β during the first week of life, and colostrum TNF-α was positively associated with calves' serum TNF-α during the first 2 wk of life. Serum IL-1β concentrations differed over the 3 wk, being the highest during the first week and the lowest during the second week. For IL-6, the concentration during the first week was the highest, and for TNF-α, a steady decline in the concentration was observed. Serum SAA concentrations were elevated during the first 2 wk of life and subsequently declined during the third week. Albumin concentrations were lowest in the first week, whereas Hp concentrations were highest during the second week. Serum concentrations of SAA, Hp, IL-6, and TNF-α during the second week were negatively associated with ADWG at 9 mo of age. The SAA concentrations during the third week of age had a negative association with 9-mo ADWG. Serum Hp concentrations in the third week were negatively associated with 3-mo ADWG. The results of our study suggest that colostrum cytokines influence calf serum cytokine concentrations. Thus, they influence the newborn calves' adaptation to the environment and the development of their immune system. Factors that activate an APR during the second and third week of life have a long-term influence on calves' development.

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Factors affecting sow colostrum yield and composition, and their impact on piglet growth and health

et al. 2019

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Serum amyloid A and haptoglobin concentrations in relation to growth and colostrum intake in neonatal lambs

Cited by 7 publications

References 21 publications

Acute‐phase proteins, cortisol and haematological parameters in ewes during the periparturient period

Acute‐phase proteins, cortisol and haematological parameters in ewes during the periparturient period

Effect of colostrum on the acute-phase response in neonatal dairy calves

Factors affecting sow colostrum yield and composition, and their impact on piglet growth and health

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