Serum amyloid A as a marker to detect sepsis and predict outcome in hospitalized neonatal foals

Hoeberg, Emma; Sånge, Alexandra; Saegerman, Claude; Bohlin, Anna; Nostell, Katarina; Durie, Inge; Husted, Louise; Öhman, Annika; Jacobsen, Stine; Berg, Lise C.; Laursen, Sigrid Hyldahl; Galen, Gaby Van

doi:10.1111/jvim.16550

Cited by 10 publications

(6 citation statements)

References 37 publications

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“…However, further studies with bigger case numbers are needed to better compare the usefulness of these two biomarkers to predict sepsis. A recent study with larger case numbers and similar sepsis categorisation revealed an optimal cut-off value of 1050 mg/L for SAA as predictor of sepsis [16], demonstrating how strong these values can fluctuate based on study population. Considering how useful and popular SAA has become in equine medicine, identifying another biomarker that performs similarly with regards to sensitivity and specificity during early testing phases is promising.…”

Section: Discussionmentioning

confidence: 93%

Use of admission serum neutrophil gelatinase-associated lipocalin (NGAL) concentrations as a marker of sepsis and outcome in neonatal foals

Laurberg,

Saegerman,

Jacobsen

et al. 2023

PLoS ONE

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Background Equine neonatal sepsis can be challenging to diagnose and prognosticate. Neutrophil gelatinase-associated lipocalin (NGAL), a new marker of renal damage and inflammation, can potentially be helpful. Objectives To evaluate NGAL in neonatal foals with sepsis, and assess its relation to outcome. Animals Foals ≤ 14 days, with admission blood analysis and stored serum. Methods NGAL was measured on stored serum from 91 foals. Foals were scored for sepsis and survival and categorized according to sepsis status (septic, sick non-septic, healthy, and uncertain sepsis status) and outcome groups (survivors and non-survivors). The septic foals were further sub-categorized according to severity (normal sepsis, severe sepsis and septic shock). A Kruskal-Wallis test was used to compare serum NGAL concentrations in survivors and non-survivors, in the sepsis status groups, and in the sepsis severity groups. Optimal cut-off values for serum NGAL concentrations to diagnose sepsis and outcome were determined with receiver operating characteristic (ROC) curves. NGAL was compared to creatinine and SAA. Results Median serum NGAL concentrations were significantly higher in septic than non-septic foals. However, serum NGAL concentrations did not differ between sepsis severity subgroups. Serum NGAL concentrations were significantly lower in survivors than in non-survivors. Optimal cut-off values of serum NGAL concentrations were 455 μg/L (sensitivity 71.4%, specificity 100%) and 1104 μg/L (sensitivity 39.3%, specificity 95.2%) for predicting sepsis and non-survival, respectively. NGAL correlated to SAA, but not to creatinine. NGAL performed similarly to SAA to diagnose sepsis. Conclusion Serum NGAL concentrations may be useful for diagnosing sepsis and predicting outcome.

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Section: Discussionmentioning

confidence: 93%

Use of admission serum neutrophil gelatinase-associated lipocalin (NGAL) concentrations as a marker of sepsis and outcome in neonatal foals

Laurberg,

Saegerman,

Jacobsen

et al. 2023

PLoS ONE

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“…Several studies have investigated the utility of SAA in predicting sepsis, either alone or in combination with other biomarkers. Many animal studies found that SAA concentration was higher in septic groups and can be used as a marker to rule out sepsis and nonsurvival 26,27 . Yuan et al concluded that the level of SAA in sepsis is most useful in combination with other markers such as CRP and PCT as well as determining their correlation and SAA could be promising and meaningful in the diagnosis of neonatal sepsis 28 .…”

Section: Discussionmentioning

confidence: 99%

A biomarker panel of C-reactive protein, procalcitonin and serum amyloid A is a predictor of sepsis in severe trauma patients

Li,

Qin,

Zhang

et al. 2024

Sci Rep

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Severe trauma could induce sepsis due to the loss of control of the infection, which may eventually lead to death. Accurate and timely diagnosis of sepsis with severe trauma remains challenging both for clinician and laboratory. Combinations of markers, as opposed to single ones, may improve diagnosis. We compared the diagnostic characteristics of routinely used biomarkers of sepsis alone and in combination, trying to define a biomarker panel to predict sepsis in severe patients. This prospective observational study included patients with severe trauma (Injury severity score, ISS = 16 or more) in the emergency intensive care unit (EICU) at a university hospital. Blood samples were collected and plasma levels of procalcitonin (PCT), C-reactive protein (CRP), interleukin-6 (IL-6) and serum amyloid A (SAA) were measured using commercial enzyme linked immunosorbent assay (ELISA) kits. A total of 100 patients were eligible for analysis. Of these, 52 were diagnosed with sepsis. CRP yielded the highest discriminative value followed by PCT. In multiple logistic regression, SAA, CRP, and PCT were found to be independent predictors of sepsis. Bioscore which was composed of SAA, CRP, and PCT was shown to be far superior to that of each individual biomarker taken individually. Therefore, compared with single markers, the biomarker panel of PCT, CRP, and SAA was more predictive of sepsis in severe polytrauma patients.

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“…Many animal studies found that SAA concentration was higher in septic groups and can be used as a marker to rule out sepsis and nonsurvival. [30,31]. Yuan et al concluded that the level of SAA in sepsis is most useful in combination with other markers such as CRP and PCT as well as determining their correlation and SAA could be promising and meaningful in the diagnosis of neonatal sepsis [32].…”

Section: Discussionmentioning

confidence: 99%

A biomarker panel of C-reactive protein, procalcitonin and serum amyloid A is a predictor of sepsis in severe trauma patients: a case control study

Qin

Zhang

et al. 2023

Preprint

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Background Severe trauma could induce sepsis due to the loss of control of the infection, which may eventually lead to death. Accurate and timely diagnosis of sepsis with severe trauma remains challenging both for clinician and laboratory. Combinations of markers, as opposed to single ones, may improve diagnosis. We therefore compared the diagnostic characteristics of routinely used biomarkers of sepsis alone and in combination, trying to define a biomarker panel to predict sepsis in severe patients. Methods This prospective observational study included patients with severe trauma(ISS 16 or more) in the EICU at a university hospital. Blood samples were collected at 8 a.m. every day after admission to the EICU, until the day included patients were transferred out of EICU. Plasma levels of PCT, CRP, IL-6 and SAA were measured using commercial ELISA kits. Receiver operating characteristic (ROC) curves were used to evaluate the ability of the biomarkers to identify the possibility of sepsis in the enrolled patients. Logistic regression models were used to identify independent risk factors for sepsis. Results A total of 100 patients were eligible for analysis. Of these, 52 were diagnosed with sepsis. CRP yielded the highest discriminative value with an area under the ROC curve (AUC) of 0.82 (82% confidence interval [CI], 0.73–0.91; P<0.001), followed by PCT (AUC 0.77 [0.68–0.86]; P<0.001). Whereas, in multiple logistic regression, SAA, CRP, and PCT were found to be independent predictors of sepsis. Bioscore which was composed of SAA, CRP, and PCT, with AUC=0.89(95%CI, 0.82-0.95), cut-off=0.28, sensitivity=0.77, specificity=0.9, P<0.001, was shown to be far superior to that of each individual biomarker taken individually. Conclusions Compared with single markers, the biomarker panel of PCT, CRP, and SAA was more predictive of sepsis in severe polytrauma patients.

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Serum amyloid A as a marker to detect sepsis and predict outcome in hospitalized neonatal foals

Cited by 10 publications

References 37 publications

Use of admission serum neutrophil gelatinase-associated lipocalin (NGAL) concentrations as a marker of sepsis and outcome in neonatal foals

Use of admission serum neutrophil gelatinase-associated lipocalin (NGAL) concentrations as a marker of sepsis and outcome in neonatal foals

A biomarker panel of C-reactive protein, procalcitonin and serum amyloid A is a predictor of sepsis in severe trauma patients

A biomarker panel of C-reactive protein, procalcitonin and serum amyloid A is a predictor of sepsis in severe trauma patients: a case control study

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