Serum amyloid A, fetuin-A, and pentraxin-3 levels in patients with ischemic stroke: novel prognostic biomarkers?

Sezer, Sevilay; Uçar, Fatma; Ulusoy, Ersin Kasım; Erdoğan, Serpil; Bilen, Şule; Züngün, Cevdet; Uysal, Sema; Erdemli, Hacı Kemal

doi:10.3906/sag-1211-90

Cited by 23 publications

(22 citation statements)

References 27 publications

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“…SAA is also a sensitive marker of the acute inflammation and its serum concentrations increase in response to infection, trauma or stress. Whether SAA could be used as a specific diagnostic tool in AIS is still inconclusive [28,29]. Our study showed that the level of SAA was increased after stroke but did not show a significant relationship between SAA and serum sST2.…”

Section: Discussioncontrasting

confidence: 58%

Serum Soluble ST2 as a Novel Inflammatory Marker in Acute Ischemic Stroke

Chen¹,

Ao²,

Yu³

et al. 2018

Clin. Lab.

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Background: Soluble ST2 (sST2) receptor is secreted and detectable in human serum, which acts as a decoy receptor for interleukin (IL)-33 to prevent IL-33-mediated Th2 immune responses. Recently, elevated serum sST2 has been found to be a novel biomarker in cardiovascular diseases such as heart failure and atherosclerosis. Here, we studied the role of sST2 in acute ischemic stroke (AIS) and its relationship with several inflammatory markers. Methods: The study included 112 patients with first-ever acute ischemic stroke, who were admitted within 48 hours after stroke onset. The serum levels of sST2 and IL-33 were measured with ELISA and the severity of AIS patients was evaluated based on the National Institutes of Health Stroke Scale (NIHSS) score. The cerebral infarct volume was calculated according to the Pullicino formula based on the cranial CT scan or MRI. High-sensitivity C-reactive protein (hs-CRP) and serum amyloid A protein (SAA) were measured using the latex-enhanced immunoturbidimetric assay. Results: The serum sST2 level was significantly increased in patients with AIS compared to the control patients without AIS. In addition, the concentration of serum sST2 increased with the infarct volume and the severity of AIS evaluated based on the NIHSS score. Furthermore, the sST2 level correlated positively with the inflammatory marker hs-CRP. Conclusions: Our study suggests that sST2 may be used as a novel diagnostic and predicting inflammatory marker in AIS.

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Section: Discussioncontrasting

confidence: 58%

Serum Soluble ST2 as a Novel Inflammatory Marker in Acute Ischemic Stroke

Chen¹,

Ao²,

Yu³

et al. 2018

Clin. Lab.

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“…Prior work has shown that PTX3 is an inflammatory marker associated with coronary artery disease (10). In cerebrovascular diseases, PTX3 represents baseline atherosclerotic burden more accurately in acute stroke and is related to the severity of the stroke (11). In order to reflect the level of PTX3 more timely and accurately, we detected the concentration of PTX3 within 48 h after ischemic stroke.…”

Section: Discussionmentioning

confidence: 99%

Pentraxin 3, TNF-α, and LDL-C Are Associated With Carotid Artery Stenosis in Patients With Ischemic Stroke

Tang

Shi

et al. 2020

Front. Neurol.

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Background: Carotid artery stenosis (CAS), typically resulting from atherosclerotic progression, is more common than intracranial atherosclerotic disease in patients with cerebrovascular disease. Prior literature has incompletely established the relationship of Pentraxin 3 (PTX3) and CAS complexity and severity. This study aims to more thoroughly evaluate the association of plasma PTX3 levels and the prevalence and severity of CAS in patients with cerebrovascular disease. Methods: Two hundred and six patients with ischemic stroke underwent multiphase computerized tomography angiography (CTA) of the head and neck to assess the presence and severity of carotid artery stenosis. Patients were divided into groups with either no carotid artery stenosis (CAS-free) or carotid artery stenosis (CAS). The CAS group was further divided into groups based on the degree of stenosis and the number of involved vessels. The PTX3 and Tumor Necrosis Factor-alpha (TNF-α) concentration were measured by ELISA. Results: Plasma levels of PTX3, TNF-α, and low-density lipoprotein cholesterol (LDL-C) were increased significantly in the CAS group patients vs. the CAS-free group (p = 0.000, 0.002, 0.002, respectively). Within the CAS group, PTX3, TNF-α, and LDL-C were significantly elevated in stenosis of ≥50% group compared to <50% group (p = 0.001, 0.002, 0.049, respectively). The multivariate logistic binary regression analysis revealed that increased age, elevated levels of PTX3, LDL-C, and TNF-α were all independent risk factors for occurrence of carotid stenosis. PTX3 level correlated with the severity of carotid stenosis. Conclusions: High plasma PTX3 levels, TNF-α, and LDL-C are significantly correlated with the prevalence and severity of carotid artery stenosis. PTX3 may be a more powerful predictor for the severity of carotid artery stenosis.

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“…Sezer et al (2014) investigated the levels of fetuin-A, Pentraxin-3, and serum amyloid A in a group of patients with ischemic stroke. Their results proved a signi cant correlation between the in ammatory factors and disease severity and progression [57]. The positive correlation between high plasma fetuin-A concentrations and a signi cantly higher risk of ischemic stroke and myocardial infarction was found in the patients from the EPIC-Potsdam Study with ischemic stroke and myocardial infarction [49,58].…”

Section: Fetuin a In Stroke Patientsmentioning

confidence: 89%

Fetuin-A – Alpha2-Heremans-Schmid Glycoprotein: From Structure to a Novel Marker of Chronic Diseases Part 2. Fetuin-A – A Marker of Insulin Resistance and Related Chronic Diseases

Komsa-Penkova

Kovacheva

Golemanov

et al. 2018

Journal of Biomedical and Clinical Research

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Summary Fetuin-A is a secretory liver glycoprotein with multiple physiological functions such as regulation of insulin resistance, tissue calcification, bone metabolism, cellular proteolytic activity, and self-proliferative signaling. Fetuin-A is a unique molecule which binds to the insulin receptor, modulating its sensitivity, and transducing “the physiological conditions” (serum levels of the metabolites like glucose, free fatty acids, inflammatory signals) from outside into inside the cells. Plasma fetuin-A levels correlate with reduced glucose tolerance and insulin resistance. Impaired insulin sensitivity leads to the development of metabolic syndrome, an increased risk for type 2 diabetes (T2DM), dyslipidaemias and cardiovascular diseases (CVDs). Furthermore, fetuin-A inversely correlates with inflammatory and activation biomarkers, e.g. in patients with T2DM. Thus, circulatory fetuin-A levels may have plausible predictive importance as a biomarker of risk of diabetes and negative acute phase protein. Dysregulated, it plays a crucial role in the pathogenesis of some metabolic disorders and clinical inflammatory conditions like metabolic syndrome, T2DM, CVDs, polycystic ovary syndrome (PCOS), etc.

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Serum amyloid A, fetuin-A, and pentraxin-3 levels in patients with ischemic stroke: novel prognostic biomarkers?

Cited by 23 publications

References 27 publications

Serum Soluble ST2 as a Novel Inflammatory Marker in Acute Ischemic Stroke

Serum Soluble ST2 as a Novel Inflammatory Marker in Acute Ischemic Stroke

Pentraxin 3, TNF-α, and LDL-C Are Associated With Carotid Artery Stenosis in Patients With Ischemic Stroke

Fetuin-A – Alpha2-Heremans-Schmid Glycoprotein: From Structure to a Novel Marker of Chronic Diseases Part 2. Fetuin-A – A Marker of Insulin Resistance and Related Chronic Diseases

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