Serum Amyloid A Promotes Invasion of Feline Mammary Carcinoma Cells

Tamamoto, Takashi; Ohno, Koichi; Goto‐Koshino, Yuko; Tsujimoto, Hajime

doi:10.1292/jvms.14-0108

Cited by 11 publications

(14 citation statements)

References 30 publications

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“…Increases in circulating CRP, SAA and Hp have been detected in female dogs with mammary cancer with metastasis in regional lymph nodes and/or distant organs (clinical stages IV and V) when compared with diseased females without metastasis and also with controls in the study of Tecles et al 22 however, no significant differences in CRP or Hp were detected between diseased dogs with and without lymph node metastasis in the study of Planellas et al 23 In the feline species, an in vitro study showed that SAA promotes invasion of mammary carcinoma cells. 60 In addition, higher concentrations of enzymatic antioxidants, including GPox, were described in neoplastic tissues of bitches with mammary tumours in clinical stages III and IV when compared with animals with mammary tumours of clinical stages I and II. 57 In the present study, serum Hp at diagnosis was higher in cases of neoplasms with vascular invasion, with metastasis in regional lymph nodes and with metastasis in distant organs, suggesting that it might be clinically useful in assessment of metastatization of feline mammary tumours.…”

Section: Discussionmentioning

confidence: 99%

Acute phase proteins and biomarkers of oxidative status in feline spontaneous malignant mammary tumours

Vilhena

Tvarijonaviciute

Cerón

et al. 2019

Vet Comparative Oncology

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Acute phase proteins (APP) and biomarkers of oxidative status change in human and canine mammary tumours, however, they have not been studied in feline mammary tumours. The aims of this study were to investigate the APP and antioxidant responses in feline malignant mammary tumours, to evaluate their relation with tumour features, and to assess their prognostic value. Serum amyloid A (SAA), haptoglobin (Hp), albumin, butyrylcholinesterase (BChE), insulin‐like growth factor1 (IGF1), paraoxonase1 (PON1), total serum thiols (Thiol), glutathione peroxidase (GPox) and total antioxidant capacity determined by different assays, including trolox equivalent antioxidant capacity assessed by two different methodologies (TEAC1/2), ferric reducing ability of plasma (FRAP), and cupric reducing antioxidant capacity (CUPRAC), were determined in serum of 50 queens with spontaneous mammary carcinomas and of 12 healthy female cats. At diagnosis, diseased queens presented significantly higher SAA and Hp, and lower albumin, BChE, GPox, TEAC1, TEAC2 and CUPRAC than controls. Different tumour features influenced concentrations of APP and antioxidants. Increases in serum Hp, and decreases in albumin, Thiol and FRAP were significantly associated with neoplastic vascular emboli, metastasis in regional lymph nodes and/or in distant organs. Distant metastasis development during the course of the disease was associated with increases in SAA and TEAC1. At diagnosis, decreased albumin was associated with a longer survival, and BChE <1.15 μmoL/mL.minute was associated with a shorter survival time on multivariate analysis. Feline malignant mammary tumours are associated with an APP response and oxidative stress, and different tumour features influence the inflammatory response and the oxidative damage. Furthermore, some of these analytes proved to have prognostic value.

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Section: Discussionmentioning

confidence: 99%

Acute phase proteins and biomarkers of oxidative status in feline spontaneous malignant mammary tumours

Vilhena

Tvarijonaviciute

Cerón

et al. 2019

Vet Comparative Oncology

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“…It is known to be increased in immune-mediated diseases, in tumors with inflammation, in infections, specifically those caused by Hemoplasma spp. [9], as well as in urinary tract disorder, post-surgery [4], pancreatitis [10], injury, infection-related disease, feline lower urinary tract disease, tumor, hyperthyroidism, diabetes mellitus [5,11,12], renal disease [5,7,13,14], mammary tumors [15], lymphoma, mesothelioma [16], feline infectious peritonitis [5,7,17,18], and sepsis [19], and is reported to be useful as a diagnostic aid. These reports include endocrine diseases not generally associated with inflammation, such as hyperthyroidism or diabetes mellitus.…”

Section: Discussionmentioning

confidence: 99%

A Clinical Investigation on Serum Amyloid A Concentration in Client-Owned Healthy and Diseased Cats in a Primary Care Animal Hospital

Yuki

Aoyama

Nakagawa

et al. 2020

Veterinary Sciences

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Although measurement of serum amyloid A (SAA) concentration in client-owned cats has already been shown to be clinically useful, limited data are available on common diseases at primary care hospitals. In this study, we measured the SAA concentration in cats with various diseases and investigated their clinical significance using a primary care hospital as a population. We measured the SAA concentrations in healthy cats (n = 98) and those with various clinical signs (n = 444). The SAA concentrations in healthy cats did not differ significantly by age, breed, sex, and presence/absence of neutering/spaying. The SAA concentrations were significantly higher in the diseased cat group than in the healthy cat group (p < 0.001). We observed significant increases in SAA concentrations in cats with confirmed diagnosis of inflammatory disease such as upper respiratory tract infections (p < 0.001), pneumonia (p < 0.001), pyometra (p = 0.001), and feline infectious peritonitis (p < 0.001), compared with those observed in healthy cats. Conversely, no increase was observed in cardiomyopathy, hyperthyroidism, and diabetes mellitus without systemic inflammation. In univariate analysis, survival at 30 days (p = 0.03) differed significantly between the low and high SAA concentration groups, but not at 180 days. In multivariate analysis, survival at 30 days did not significantly affect SAA concentration. Measurement of SAA concentration is a useful biomarker for detecting the presence or absence of inflammation in diseased cats. However, it may not be useful as a biomarker for determining the prognosis of the disease.

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“…Together, the results of this meta- analysis should be more stable. Previous studies have found that SAA can distinguish lung cancer patients from healthy controls as well as predict prognosis of lung cancer [8, 12, 15, 17]. SAA is secreted during the acute phase of inflammation, including invertebrates and vertebrates, suggests that SAA has an essential role in all animals including humans [15].…”

Section: Discussionmentioning

confidence: 99%

“…Serum amyloid A (SAA), a kind of cytokine-induced, acute inflammatory response proteins, has been known to be likely involved in cancers [7]. Research shows that liver is mainly workplace for producing SAA protein which can stimulates the production of various cytokines, and SAA plays an important role in acute immune response [8]. SAA protein in blood of patients with cancer often rises at its early stage, which have been identified both by immunochemistry and by proteomics methods in different cancers, such as lung, ovarian, renal, uterine, nasopharyngeal cancer and in melanoma [7].…”

Section: Introductionmentioning

confidence: 99%

Increased serum amyloid A as potential diagnostic marker for lung cancer: a meta-analysis based on nine studies

et al. 2016

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BackgroundPrevious studies have disclosed that serum amyloid A (SAA) is likely involved in the lung cancer pathogenesis and progression. We performed a systematic evaluation and meta-analysis to disclose the correlation between the expression of SAA and lung cancer and to evaluate its value for lung cancer diagnosis.MethodsWe searched the relevant articles from the databases of Medline, Embase, Cochrance Library and Web of Science and calculated the standardized mean difference (SMD) with 95 % confidence interval (CI) to assess the expression difference of SAA between lung cancer and normal patients. Moreover, we counted the positive rate, sensitivity and specificity and drew a summary receiver operating characteristic curve (SROC) to evaluate the diagnostic value of SAA for lung cancer.ResultsA total of nine studies with 1392 individuals were included in this analysis. The results showed an increased SAA was correlated with the incidence of lung cancer (P < 0.001), especially with the lung squamous cell carcinoma (LSCC) (p = 0.012). The overall sensitivity and specificity of SAA for discerning lung cancer was 0.59 (95 % CI: 0.54–0.63) and 0.92 (95 % CI: 0.88–0.95), respectively. The area under the SROC curve was 0.9066 (SE = 0.0437).ConclusionsIncreased SAA in lung cancer was intimately correlated with the development and progression of lung cancer. A higher specificity of SAA suggested that it should be a significant biomarker for discerning lung cancer from normal individuals, especially for LSCC (p = 0.012).

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Serum Amyloid A Promotes Invasion of Feline Mammary Carcinoma Cells

Cited by 11 publications

References 30 publications

Acute phase proteins and biomarkers of oxidative status in feline spontaneous malignant mammary tumours

Acute phase proteins and biomarkers of oxidative status in feline spontaneous malignant mammary tumours

A Clinical Investigation on Serum Amyloid A Concentration in Client-Owned Healthy and Diseased Cats in a Primary Care Animal Hospital

Increased serum amyloid A as potential diagnostic marker for lung cancer: a meta-analysis based on nine studies

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