Serum amyloid A1 and pregnancy zone protein in pregnancy complications and correlation with markers of placental dysfunction

Fosheim, Ingrid Knutsdotter; Jacobsen, Daniel Pitz; Sugulle, Meryam; Alnæs-Katjavivi, Patji; Fjeldstad, Heidi Elisabeth; Ueland, Thor; Lekva, Tove; Staff, Anne Cathrine

doi:10.1016/j.ajogmf.2022.100794

Cited by 4 publications

(3 citation statements)

References 60 publications

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“…SSA1 has been shown to be produced by placental trophoblasts and to increase at time of parturition 37 . It has also been found to be associated with preeclampsia and placental dysfunction 38 .…”

Section: Discussionmentioning

confidence: 99%

Differential gene expression in two consecutive pregnancies between same sex siblings and implications on maternal constraint

Kallak,

Serapio,

Visser

et al. 2024

Sci Rep

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The objective of this study was to investigate how placental gene expression differs in two consecutive pregnancies in same sex siblings, and its possible association with the “maternal constraint” hypothesis. Material was gathered from the BASIC study (Biological, Affect, Stress, Imaging, and Cognition in Pregnancy and the Puerperium), a population based prospective study that was started in 2009 in Uppsala. Over 900 specimens of placenta biopsies were collected and out of these 10 women gave birth twice, to the same sex child, and were included in this study. The total RNA was isolated and prepared from frozen villous tissue from the placenta and further analyzed by use of Ion AmpliSeq Human Transcriptome Gene Expression kit. A total of 234 genes differed significantly between the first and second pregnancy placentas, when adjusting for delivery mode, maternal BMI and gestational age. Of special interest was the down-regulated group of genes in the second pregnancy. Exemplified by Pentraxin 3, SRY-Box Transcription Factor 9, and Serum Amyloid A1, which all were associated with biological processes involved in the immune system and inflammation. Further, protein–protein interaction analysis visualized them as hub genes interacting with several of the other differentially expressed genes. How these altered gene expressions affect maternal constraint during pregnancy needs further validation in lager study cohorts and also future validation in functional assays.

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Section: Discussionmentioning

confidence: 99%

Differential gene expression in two consecutive pregnancies between same sex siblings and implications on maternal constraint

Kallak,

Serapio,

Visser

et al. 2024

Sci Rep

View full text Add to dashboard Cite

show abstract

“…It is highly uncertain whether elevations in PZP are helpful or detrimental to CV health. So far, most PZP studies have been focused on pregnant women [ 18 , 21 , 31 ]. It has been proposed that low PZP levels during gestation may raise the risk of placental dysfunction [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Pregnancy Zone Protein as an Emerging Biomarker for Cardiovascular Risk in Pediatric Chronic Kidney Disease

Chen,

Liao,

Hsu

et al. 2023

JCM

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Cardiovascular disease (CVD) is a significant cause of mortality and morbidity among children with chronic kidney disease (CKD). The causes of pediatric CKD differ from those in adults, as congenital anomalies in the kidney and urinary tract (CAKUT) are the leading causes in childhood. Identifying ideal markers of CVD risk early is crucial for CKD children to improve their care. Previously, we screened differentially expressed proteins in CKD children with or without blood pressure (BP) abnormalities and identified pregnancy zone protein (PZP). In 106 children and adolescents with CKD stages G1–G4, we analyzed plasma PZP concentration. The associations between PZP and ambulatory BP monitoring (ABPM) profile, parameters of cardiac and carotid ultrasounds, indices of arterial stiffness, and nitric oxide (NO) parameters were determined. We observed that PZP positively correlated with arterial stiffness indices, beta index, and pulse wave velocity in CAKUT. CKD children with abnormalities in ABPM and night dipping displayed a higher PZP concentration than those without. Additionally, the PZP level was positively correlated with NO bioavailability. In conclusion, our results suggest PZP has differential influences on cardiovascular risk in CAKUT and non-CAKUT children. Identification of this relationship is novel in the pediatric CKD literature.

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“…Moreover, PZP stabilizes misfolded proteins [53]. Altered expression of PZP was detected in early pregnancy disorders [54][55][56].…”

Section: Discussionmentioning

confidence: 99%

Quantitative Proteomics of Maternal Blood Plasma in Isolated Intrauterine Growth Restriction

Starodubtseva,

Tokareva,

Volochaeva

et al. 2023

IJMS

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Intrauterine growth restriction (IUGR) remains a significant concern in modern obstetrics, linked to high neonatal health problems and even death, as well as childhood disability, affecting adult quality of life. The role of maternal and fetus adaptation during adverse pregnancy is still not completely understood. This study aimed to investigate the disturbance in biological processes associated with isolated IUGR via blood plasma proteomics. The levels of 125 maternal plasma proteins were quantified by liquid chromatography-multiple reaction monitoring mass spectrometry (LC-MRM MS) with corresponding stable isotope-labeled peptide standards (SIS). Thirteen potential markers of IUGR (Gelsolin, Alpha-2-macroglobulin, Apolipoprotein A-IV, Apolipoprotein B-100, Apolipoprotein(a), Adiponectin, Complement C5, Apolipoprotein D, Alpha-1B-glycoprotein, Serum albumin, Fibronectin, Glutathione peroxidase 3, Lipopolysaccharide-binding protein) were found to be inter-connected in a protein–protein network. These proteins are involved in plasma lipoprotein assembly, remodeling, and clearance; lipid metabolism, especially cholesterol and phospholipids; hemostasis, including platelet degranulation; and immune system regulation. Additionally, 18 proteins were specific to a particular type of IUGR (early or late). Distinct patterns in the coagulation and fibrinolysis systems were observed between isolated early- and late-onset IUGR. Our findings highlight the complex interplay of immune and coagulation factors in IUGR and the differences between early- and late-onset IUGR and other placenta-related conditions like PE. Understanding these mechanisms is crucial for developing targeted interventions and improving outcomes for pregnancies affected by IUGR.

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Serum amyloid A1 and pregnancy zone protein in pregnancy complications and correlation with markers of placental dysfunction

Cited by 4 publications

References 60 publications

Differential gene expression in two consecutive pregnancies between same sex siblings and implications on maternal constraint

Differential gene expression in two consecutive pregnancies between same sex siblings and implications on maternal constraint

Pregnancy Zone Protein as an Emerging Biomarker for Cardiovascular Risk in Pediatric Chronic Kidney Disease

Quantitative Proteomics of Maternal Blood Plasma in Isolated Intrauterine Growth Restriction

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