Serum and aqueous humor vitamin D levels in patients with diabetic macular edema

Kim, Kyoung Lae; Moon, Su Young; Noh, Hye-Mi; Park, Sung Pyo; Kim, Yong-Kyu

doi:10.1007/s00417-019-04305-2

Cited by 12 publications

(15 citation statements)

References 30 publications

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“…[13,14] Accordingly, some authors have suggested that intraocular 25(OH)D levels may not depend on systemic 25(OH)D levels. [1] It has also been reported that the 1,25dihydroxycholecalciferol can upregulate the expression of the VEGFs; it has been shown that the regulation of VEGF promoter by vitamin D receptor increases the secretion of VEGFs in vascular smooth muscles. [15,16] A similar effect has not been established in retinal cells, however, this finding can hypothesize a correlation between high ocular vitamin D levels and high concentration of ocular VEGFs.…”

Section: Discussionmentioning

confidence: 97%

“…[15,16] A similar effect has not been established in retinal cells, however, this finding can hypothesize a correlation between high ocular vitamin D levels and high concentration of ocular VEGFs. [1] Previous studies have revealed paradoxical results about the relationship between the severity of DR and serum 25(OH)D levels. Some authors have reported an inverse relationship, [10,11,[17][18][19] while others have not shown such a correlation.…”

Section: Discussionmentioning

confidence: 99%

“…[22] On the other hand, a recent study performed by Kim et al reported that patients with DME had a greater aqueous humor amounts of vitamin D than the patients without DME. [1] It should also be considered that studies on vitamin D levels encounter some challenges such as different cultural backgrounds as well as different Since the prior studies have not resulted in an exact conclusion about vitamin D and its role in DR, we investigated the treatment of DME with an anti-VEGF agent, bevacizumab, in the presence of vitamin D deficiency. We also tested the role of concurrent vitamin D3 therapy in optimizing the IVB therapy for DME.…”

Section: Discussionmentioning

confidence: 99%

“…of diabetic retinopathy (DR). [1] DME is the main cause of decreased vision in diabetic patients. [1] Elevated levels of various inflammatory and angiogenic factors lead to serious damage of retinal vascular endothelial cells, and the consequent impairment of blood-retinal barrier (BRB) causes fluid accumulation in the retinal tissue.…”

Section: Diabetic Macular Edema (Dme) May Develop In Diabetic Patients Independent Of the Severitymentioning

confidence: 99%

“…[1] DME is the main cause of decreased vision in diabetic patients. [1] Elevated levels of various inflammatory and angiogenic factors lead to serious damage of retinal vascular endothelial cells, and the consequent impairment of blood-retinal barrier (BRB) causes fluid accumulation in the retinal tissue. [2] Vitamin D is a well-known endocrine secosteroid which plays an essential role in many physiologic processes, including the control of cellular apoptosis and differentiation, as well as angiogenesis and metastasis potential of human cancer cells.…”

Section: Diabetic Macular Edema (Dme) May Develop In Diabetic Patients Independent Of the Severitymentioning

confidence: 99%

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Effects of Oral Vitamin D Supplement Therapy on Clinical Outcomes of Intravitreal Bevacizumab in Diabetic Macular Edema

Karimi

Movafaghi

Arabi

et al. 2021

JOVR

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Purpose: To assess the effects of oral vitamin D supplement therapy on clinical outcomes of intravitreal bevacizumab (IVB) injections in patients with diabetic macular edema (DME). Method: Seventy-one patients with center-involving DME received IVB injections three times monthly. Cases with serum 25-hydroxyvitamin D (25(OH)D) levels <30 ng/ml were divided into treatment and control groups. The treatment group received 50000 IU of oral vitamin D once a week for eight weeks. One month after the third IVB injection, changes in the best-corrected visual acuity (BCVA) and central macular thickness (CMT) were analyzed for each group. Results: Thirty-seven patients had sufficient levels of 25 (OH) D, while 34 patients had insufficient levels. Nineteen cases with deficient levels of 25(OH)D were treated with oral vitamin D, while 15 patients were assigned to the control group. The mean of serum 25(OH)D in patients was 27.9 ng/ml [mean 20.3 ± 5.4 and 17.3 ± 5.4 ng/ml in control and treatment groups, respectively (P = 0.231)]. After three IVB injections, BCVA improved significantly in each group, but the difference between the study groups was not statistically significant. CMT decreased significantly in all the groups. The mean CMT reduction was more prominent in the vitamin D-treated group, but the difference between groups did not reach statistical significance (P = 0.29). Conclusion: In DME patients with vitamin D deficiency, vitamin D supplement therapy had some beneficial effects on CMT reduction following three injections of IVB; nevertheless, these effects were not statistically significant. Definite conclusion needs further prospective studies with a larger sample size.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Diabetic Macular Edema (Dme) May Develop In Diabetic Patients Independent Of the Severitymentioning

confidence: 99%

Section: Diabetic Macular Edema (Dme) May Develop In Diabetic Patients Independent Of the Severitymentioning

confidence: 99%

See 3 more Smart Citations

Effects of Oral Vitamin D Supplement Therapy on Clinical Outcomes of Intravitreal Bevacizumab in Diabetic Macular Edema

Karimi

Movafaghi

Arabi

et al. 2021

JOVR

View full text Add to dashboard Cite

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Sample preparation techniques for extraction of vitamin D metabolites from non-conventional biological sample matrices prior to LC–MS/MS analysis

Αλεξανδρίδου

Volmer

2022

Anal Bioanal Chem

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The determination of vitamin D metabolites as status marker or for diagnostic purposes is almost entirely conducted from blood serum or plasma. Other biological matrices, however, have also interested researchers, for two main reasons: (1) alternative matrices may allow non-invasive sampling, permit easier sample transfer and require less demanding storage conditions; and (2) the levels of vitamin D metabolites in other body compartments may further aid the understanding of vitamin D metabolism and function. Thus, the development of reliable and efficient sample preparation protocols for sample matrices other than serum/plasma, which will remove potential interferences and selectively extract the targeted metabolites, is of great importance. This review summarizes sample preparation methods for measurement of vitamin D metabolites using liquid chromatography-(tandem)mass spectrometry in more than ten different human tissues, including hair, saliva, adipose tissue, brain and others. Graphical abstract

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Associations between vitamin D status and sight threatening and non-sight threatening diabetic retinopathy: a systematic review and meta-analysis

Trott

Driscoll

Iraldo

et al. 2022

J Diabetes Metab Disord

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Background Vitamin D levels have been shown to be associated with diabetic retinopathy, however to date, no review has examined the relationship between vitamin D and sight threatening diabetic retinopathy (STDR) and non-sight threatening diabetic retinopathy (NSTDR). The aim of this review, therefore, was to pool associations between vitamin D deficiency (25(OH)D < 20 ng/mL) and STDR/NSTDR. A further aim was to examine associations between circulating 25(OH)D levels and STDR/NSTDR. Methods A systematic review of major databases was undertaken for studies published from inception to 22/04/2022, using a pre-published protocol. Studies reporting prevalence of STDR or NSTDR versus a control group with diabetes and no DR or DME and either (a) vitamin D deficiency prevalence, or (b) circulating 25(OH)D levels, were included. A random effects meta-analysis was undertaken. Results Following screening, 12 studies (n = 9057) were included in the meta-analysis. STDR was significantly associated with vitamin D deficiency (OR = 1.80 95%CI 1.40–2.30; p = <0.001), whereas NSTDR was not (OR = 1.07 95%CI 0.90–1.27; p = 0.48). Both conclusions were graded as low credibility of evidence. Furthermore, circulating 25(OH)D levels were significantly associated with both NSTDR (SMD = -0.27 95%CI -0.50; −0.04; p = 0.02) and STDR (SMD = −0.49 95%CI -0.90; −0.07; p = 0.02), although these were graded as low credibility of evidence. Conclusion Vitamin D deficiency is significantly associated with STDR (including DME), but not with NSTDR. Given the well-reported associations between vitamin D deficiency and other unfavourable outcomes, it is important that vitamin D deficiency is managed appropriately and in a timely manner to reduce the risk of blindness in people with diabetes.

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Serum and aqueous humor vitamin D levels in patients with diabetic macular edema

Cited by 12 publications

References 30 publications

Effects of Oral Vitamin D Supplement Therapy on Clinical Outcomes of Intravitreal Bevacizumab in Diabetic Macular Edema

Effects of Oral Vitamin D Supplement Therapy on Clinical Outcomes of Intravitreal Bevacizumab in Diabetic Macular Edema

Sample preparation techniques for extraction of vitamin D metabolites from non-conventional biological sample matrices prior to LC–MS/MS analysis

Associations between vitamin D status and sight threatening and non-sight threatening diabetic retinopathy: a systematic review and meta-analysis

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