Serum and BAL cytokine and antioxidant enzyme levels at different stages of pneumoconiosis in coal workers

Ülker, Özge Cemiloğlu; Yücesoy, Berran; Demir, Özgür; Tekin, İshak Özel; Karakaya, Asuman

doi:10.1177/0960327108098332

Cited by 23 publications

(15 citation statements)

References 31 publications

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“…Preliminary populations findings showed that IL6 mRNA expression in peripheral blood of patients with pneumoconiosis was significantly higher than in that of controls, and in line with the screening results (3.271 times) and reports 23 , 24) . IRF2 and PTGS2 results were inconsistent with the screening results (3.269 times and 3.361 times, respectively).…”

Section: Discussionsupporting

confidence: 86%

Differential gene expression associated with inflammation in peripheral blood cells of patients with pneumoconiosis

Liu

Wang

Jiao

et al. 2016

Journal of Occupational Health

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Objectives: To study expression changes in inflammation-related genes in peripheral blood of patients with pneumoconiosis and to explore the possibility of these genes as pneumoconiosis biomarkers. Methods: Peripheral blood samples of patients with pneumoconiosis patients and controls were collected, and total RNA of the blood cells were extracted and reverse transcribed to cDNA. Screenings of deferentially expressed genes associated with inflammation between patients with pneumoconiosis and controls were performed using real-time quantitative PCR array and the expressions of the three most upregulated genes were confirmed by real-time PCR. Results: The expression of 11 genes was significantly altered in patients with pneumoconiosis compared with those of the control. Among these 11 genes, 8 genes were upregulated and 3 were downregulated. Preliminary results indicated that interleukin 6 (IL-6) mRNA expression in patients with pneumoconiosis was higher than that in controls (P=0.019). The level of IL6 mRNA expression in the patients was higher than that in non-smoking controls, but it was neither affected by type and stage of pneumoconiosis nor by time of contact with dust. Conclusions: IL6 was possibly involved in the development of pneumoconiosis.

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Section: Discussionsupporting

confidence: 86%

Differential gene expression associated with inflammation in peripheral blood cells of patients with pneumoconiosis

Liu

Wang

Jiao

et al. 2016

Journal of Occupational Health

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“…13,28 In particular, THP-1 cells have been proven helpful to study the pro-inflammatory and pro-fibrotic effects of LAR nanomaterials such as multiwalled carbon nanotubes (MWCNTs). 21,29 Using confocal microscopy to study uptake of fluorescein isothiocyanate (FITC)-labeled La 2 O 3 and Gd 2 O 3 nanoparticles, we found that most of the labeled nanoparticles colocalized with an Alexa fluor 594-labeled LAMP1-positive compartment with coefficients of colocalization ranging from 66 to 91% by Image J analysis (Figure 2A and S2A).…”

Section: Resultsmentioning

confidence: 99%

Surface Interactions with Compartmentalized Cellular Phosphates Explain Rare Earth Oxide Nanoparticle Hazard and Provide Opportunities for Safer Design

et al. 2014

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Growing international exploitation of rare earth oxides (REOs) for commercial and biological use has increased the possibility of human exposure and adverse health effects. Occupational exposure to rare earth materials in miners and polishers leads to a severe form of pneumoconiosis, while gadolinium-containing MRI contrast agents cause nephrogenic systemic fibrosis in patients with renal impairment. The mechanisms for inducing these adverse pro-fibrogenic effects are of considerable importance for the safety assessment of REO particles as well as presenting opportunities for safer design. In this study, using a well-prepared REO library, we obtained a mechanistic understanding of how REOs induce cellular and pulmonary damage by a compartmentalized intracellular biotransformation process in lysosomes that results in pro-fibrogenic growth factor production and lung fibrosis. We demonstrate that rare earth oxide ion shedding in acidifying macrophage lysosomes leads to biotic phosphate complexation that results in organelle damage due to stripping of phosphates from the surrounding lipid bilayer. This results in nanoparticle biotransformation into urchin shaped structures and setting in motion a series of events that trigger NLRP3 inflammasome activation, IL-1β release, TGF-β1 and PDGF-AA production. However, pretreatment of REO nanoparticles with phosphate in a neutral pH environment prevents biological transformation and pro-fibrogenic effects. This can be used as a safer design principle for producing rare earth nanoparticles for biological use.

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“…4,8 IL-6 is a cytokine that has been associated with silicosis. The study by Ulker et al 23 showed that bronchoalveolar lavage and the plasma concentrations of IL-6, IL-1b, and TNF-a were elevated in patients with pneumoconiosis, with higher levels found in patients with progressive massive fibrosis. Sauni et al 4 found elevated IL-6 plasma levels in construction workers exposed to silica.…”

Section: Discussionmentioning

confidence: 99%

Influence of Cytokines and Soluble Receptors in the Quality of Life and Functional Capacity of Workers Exposed to Silica

Braz¹,

Carneiro

Avelar³

et al. 2016

Journal of Occupational &Amp; Environmental Medicine

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Interleukin-6 plasma levels were higher in subjects exposed to silica with and without silicosis than in the control group. There was a positive correlation between radiological severity and the quality of life, whereas there was a negative correlation between radiological severity and pulmonary function. A negative correlation between sTNFR1 plasma level and functional capacity was found. Interleukin-10 was negatively correlated with the quality of life total score and was positively correlated with the functional capacity and pulmonary function.

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Serum and BAL cytokine and antioxidant enzyme levels at different stages of pneumoconiosis in coal workers

Cited by 23 publications

References 31 publications

Differential gene expression associated with inflammation in peripheral blood cells of patients with pneumoconiosis

Differential gene expression associated with inflammation in peripheral blood cells of patients with pneumoconiosis

Surface Interactions with Compartmentalized Cellular Phosphates Explain Rare Earth Oxide Nanoparticle Hazard and Provide Opportunities for Safer Design

Influence of Cytokines and Soluble Receptors in the Quality of Life and Functional Capacity of Workers Exposed to Silica

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