Serum and Erythrocyte Tocopherol in Uremic Patients: Effect of Hemodialysis versus Peritoneal Dialysis

Pastor, María Antonia; Sierra, Carlos; Bonal, J.; Teixidó, J

doi:10.1159/000168626

Cited by 36 publications

(12 citation statements)

References 20 publications

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“…In agreement with the results of earlier studies [43, 44, 45], we did not find any significant changes in the basal plasma levels of either α-tocopherol or α-tocopherol/total lipid between normal controls and hemodialysis patients. In addition, both α-tocopherol or α-tocopherol/total lipid levels of smokers and nonsmokers who were on hemodialysis were similar.…”

Section: Discussionsupporting

confidence: 93%

Evidence for Alterations in Circulating Low-Molecular-Weight Antioxidants and Increased Lipid Peroxidation in Smokers on Hemodialysis

Lim

Wang²,

Lu³

et al. 2001

Nephron

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Background/Aim: Cardiovascular disease is the major cause of mortality in dialysis patients, accounting for about 40% of deaths in most large registries. Oxidative stress has been strongly implicated in the pathogenesis of these events. As end-stage renal disease is a state of elevated free radical activity, the aim of the present study was to investigate the negative impact of smoking in 57 male hemodialysis patients. Methods: The patients, who were 20–85 years of age (mean age 51.0 ± 14 years), had been on hemodialysis for at least 6 months before participating in this study. Fasting blood sampling for serum lipid, albumin, urate and lipophilic antioxidants such as tocopherols, carotenes, ascorbate and lipid peroxides was performed. Results: The plasma malondialdehyde (MDA) concentration was significantly higher in hemodialysis patients who smoked compared to hemodialysis patients who were nonsmokers (1.92 ± 0.52 vs. 1.59 ± 0.42 nmol/ml, p = 0.006). No association was found between levels of MDA in smokers and parameters such as body mass index, serum cholesterol, serum triglycerides and smoking index. There were no significant differences in the plasma levels of uric acid, α-tocopherol, γ-tocopherol, δ-tocopherol, α-carotene, β-carotene and retinol between the two groups. A significantly lower level of plasma ascorbate was observed in hemodialysis patients who smoked compared to the nonsmoking hemodialysis patients or healthy controls (4.59 ± 4.0 vs. 9.57 ± 4.0 and 10.16 ± 4.6 µg/ml, p < 0.05). Moreover, in smokers, the plasma levels of ascorbate were negatively correlated with the levels of plasma MDA (r = –0.43, p < 0.001) of each patient. Partial correlation analysis of the plasma levels of the measured antioxidants and the smoking index revealed a negative correlation between the plasma levels of lipid-normalized lycopene and the smoking index (r = –0.53, p < 0.05). Conclusion: Our data suggest that cigarette smoking further increases plasma-circulating products of lipid peroxidation, which are already increased in nonsmoking hemodialysis patients as compared to matched healthy controls. The lower plasma levels of ascorbate in hemodialysis patients who smoke suggest that these patients may be more susceptible to oxidative tissue damage caused by smoking.

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Section: Discussionsupporting

confidence: 93%

Evidence for Alterations in Circulating Low-Molecular-Weight Antioxidants and Increased Lipid Peroxidation in Smokers on Hemodialysis

Lim

Wang²,

Lu³

et al. 2001

Nephron

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“…Our data confirm that dialyzed patients are in a condition of oxidative stress (high values of plasma MDA-4HNE and ROMs, low plasma thiols) which is exacerbated by the dialytic session and which is less severe in PD patients. This latter finding has been reported previously [20, 21, 22, 23], and it may be due to the lack of contact of the blood with the dialysis membrane, to the absence of intravenous iron administration, and, perhaps, to the persistence of a residual renal function in PD patients.…”

Section: Discussionsupporting

confidence: 81%

“…This may explain the lower intensity of oxidative stress described in peritoneal dialysis (PD) patients [20, 21, 22, 23]as compared with HD patients [24, 25, 26, 27, 28, 29, 30, 31, 32, 33]. …”

Section: Introductionmentioning

confidence: 99%

Oxidative Stress and Cardiovascular Disease in Dialyzed Patients

Usberti

Gerardi

Gazzotti

et al. 2002

Nephron

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Background/Aim: Oxidative damage has been suggested to play a key role in accelerated atherosclerosis and to be involved in cardiovascular disease (CVD) of dialyzed patients who are at risk of increased oxidative stress. The purpose of the present study was to examine the relationship between the severity of CVD and some markers of oxidative stress and antioxidant activity in our hemodialyzed (HD) and peritoneal dialysis (PD) patients. Methods: Plasma reactive oxygen metabolites, malondialdehyde and 4-hydroxynonenal (MDA-4HNE), thiols, α-tocopherol, and total antioxidant status (TAS) were measured in 55 HD and in 16 PD patients. CVD was considered as the result of variably combined cardiac, cerebral, and vascular pathologies which were scored and grouped in a single CVD index and analyzed with respect to the markers of the oxidative status. 16 normal subjects served as controls. Results: All patients showed evidence of increased oxidative stress which was more severe in HD than in PD patients and which was exacerbated by HD. When cardiac, cerebral, and vascular diseases were analyzed separately, plasma MDA-4HNE and TAS were significantly higher in more severely affected HD patients, but not in PD patients. In HD patients the CVD index was directly correlated with both MDA-4HNE and TAS (r = 0.42, p < 0.01; r = 0.39, p < 0.01) and inversely correlated with α-tocopherol (r = –0.32, p < 0.05). MDA-4HNE and TAS were directly correlated in HD patients and inversely correlated in control subjects. Conclusions: Our data show that, in spite of increased antioxidant defense, there is a relationship between the degree of lipid peroxidation and the severity of CVD in HD patients. Moreover, these data underscore the utility of MDA-4HNE, α-tocopherol, and TAS in the evaluation of cardiovascular disease.

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“…These findings have been replicated in several other studies performed outside the US 55,57,61,62 , though not all concur 58 .…”

Section: Evidence For Altered Requirements In Hemodialysis Patientssupporting

confidence: 55%

Is Routine Multivitamin Supplementation Necessary in US Chronic Adult Hemodialysis Patients? A Systematic Review

Tucker

Safadi

Friedman

2015

Journal of Renal Nutrition

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Serum and Erythrocyte Tocopherol in Uremic Patients: Effect of Hemodialysis versus Peritoneal Dialysis

Cited by 36 publications

References 20 publications

Evidence for Alterations in Circulating Low-Molecular-Weight Antioxidants and Increased Lipid Peroxidation in Smokers on Hemodialysis

Evidence for Alterations in Circulating Low-Molecular-Weight Antioxidants and Increased Lipid Peroxidation in Smokers on Hemodialysis

Oxidative Stress and Cardiovascular Disease in Dialyzed Patients

Is Routine Multivitamin Supplementation Necessary in US Chronic Adult Hemodialysis Patients? A Systematic Review

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