Serum and Hair Levels of Zinc and Other Elements in Dogs with Visceral Leishmaniasis

Paşa, Serdar; Kargin, Funda; Bildik, Ayşegül; Seyrek, Kamil; Özbel, Yusuf; Ozensoy, S

doi:10.1385/bter:94:2:141

Cited by 18 publications

(21 citation statements)

References 20 publications

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“…To this end, increased levels of serum copper may be explained with a relocation of copper, decrease in stores and reciprocal increase in circulating copper. Furthermore, increased serum copper concentration in infected animals observed in the present study is consistent with the previous findings that host leukocyte-induced metabolic changes resulting in an increase of serum copper (Delacruz et al 1993;Pasa et al 2003).…”

Section: Discussionsupporting

confidence: 93%

“…The trace element concentrations in serum samples change during infection (Pasa et al 2003;Wagner et al 1991). These changes are part of the defence strategies of the organism, induced by IL-1, IL-6, and TNF-α (Klasing 1988;Wagner et al 1991).…”

Section: Discussionmentioning

confidence: 99%

“…Copper is required for caeruloplasmin, which loads iron onto transferrin (Evans and Halliwell 2001). Increased plasma copper concentrations have been found in infectious processes; thus, following serum Cu concentrations is a useful monitor for some diseases (Pasa et al 2003;Schroeder et al 1967).…”

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confidence: 99%

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Serum Zinc, Iron and Copper Concentrations in Dogs Infected with Hepatozoon canis

et al. 2009

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In Turkey, canine hepatozoonosis is an emerging infection with a large number of cases detected during the past five years. In the present study, serum zinc, copper and iron concentrations of dogs infected with Hepatozoon canis were measured for the first time. Compared to the controls (n = 10), serum zinc and iron concentrations in infected animals (n = 14) decreased significantly (p < 0.05 and p < 0.01, respectively), whereas the concentrations of copper in diseased animals increased significantly (p < 0.05). In conclusion, the results of the present study indicate that Hepatozoon canis infection may cause alterations in serum zinc iron and copper concentrations. Furthermore, in the treatment of infected animals addition of zinc and iron to the ration of infected animals should be taken into consideration. Hepatozoonozis, dog, trace minerals

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

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Serum Zinc, Iron and Copper Concentrations in Dogs Infected with Hepatozoon canis

et al. 2009

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“…; Pasa et al . ), possibly related to host susceptibility (Faryadi & Mohebali ; Weyenbergh et al . ).…”

Section: Discussionmentioning

confidence: 99%

A potential link among antioxidant enzymes, histopathology and trace elements in canine visceral leishmaniasis

Souza¹,

Barreto

Silva

et al. 2014

Int J Experimental Path

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Canine visceral leishmaniasis (CVL) is a severe and fatal systemic chronic inflammatory disease. We investigated the alterations in, and potential associations among, antioxidant enzymes, trace elements and histopathology in CVL. Blood and tissue levels of Cu-Zn superoxide dismutase, catalase and glutathione peroxidase were measured in mixed-breed dogs naturally infected with Leishmania infantum chagasi, symptomatic (n = 19) and asymptomatic (n = 11). Serum levels of copper, iron, zinc, selenium and nitric oxide, and plasma lipid peroxidation were measured. Histological and morphometric analyses were conducted of lesions in liver, spleen and lymph nodes. We found lower blood catalase and glutathione peroxidase activity to be correlated with lower iron and selenium respectively. However, higher activity of Cu-Zn superoxide dismutase was not correlated with the increase in copper and decreased in zinc observed in infected animals compared to controls. Organ tissue was characterized by lower enzyme activity in infected dogs than in controls, but this was not correlated with trace elements. Lipid peroxidation was higher in symptomatic than in asymptomatic and control dogs and was associated with lesions such as chronic inflammatory reaction, congestion, haemosiderin and fibrosis. Systemic iron deposition was observed primarily in the symptomatic dogs showing a higher tissue parasite load. Dogs with symptomatic CVL displayed enhanced LPO and Fe tissue deposition associated with decreased levels of antioxidant enzymes. These results showed new points in the pathology of CVL and might open new treatment perspectives associated with antioxidants and the role of iron in the pathogenesis of CVL.

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“…[1617] Zinc is involved in the determination of structural properties of molecules concerned with connection and entry of leishmania into white blood cells. [18] Several studies have shown that the serum zinc level in patients with leishmaniasis has been lower compared to control group;[19–21] and following treatment with Antimony compounds the serum zinc level has increased. [22] Regarding the above statements, several clinical trials have been conducted to evaluate the effects of oral and intralesional zinc sulfate in the treatment of cutaneous leishmaniasis.…”

Section: Discussionmentioning

confidence: 99%

Comparison of intralesional two percent zinc sulfate and glucantime injection in treatment of acute cutaneous leishmaniasis

et al. 2012

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Introduction:Cutaneous leishmaniasis is an endemic disease in developing countries caused by different species of leishmania parasite, and if left untreated, it will result in a deformed scar after a relatively long period. Although various systemic and topical treatments have been proposed for leishmaniasis, pentavalent Antimony compounds remain the first-line treatment for it. Considering the cases with treatment failure, potential side effects and reluctance of patients to receive the drug, there are continuing efforts to find better treatment alternatives.Aim:Comparison of the effect of intralesional 2% zinc sulfate injection with Glucantime in treatment of acute cutaneous leishmaniasis.Materials and Methods:In this clinical trial, 45 patients with clinical diagnosis of cutaneous leishmaniasis and positive direct smear for leishman body were treated by intralesional injection of either 2% zinc sulfate or Glucantime. After simple randomization, in one group the patients were treated with 2 bouts of intralesional 2% zinc sulfate with a 2-week interval, and in the other group they were treated with 6 weekly bouts of intralesional Glucantime. The patients were monitored in two week intervals for 8 weeks. Healing of the lesions was evaluated clinically and by direct smear, and the data were analyzed using SPSS (11.5) software, t-Student, Mann-Whitney and Analysis of covariance (ANCOVA) statistical tests.Findings:In the end of study, 34 patients completed the study, 10 of whom received intralesional Glucantime and 24 of whom received intralesional 2% zinc sulfate. The healing rate after 8 weeks was 80% in the group receiving intralesional Glucantime and 33.3% in the one receiving 2% zinc sulfate (P=0.009).Conclusion:Based on the results of this study, intralesional injection of 2% zinc sulfate was less effective in treatment of cutaneous leishmaniasis than intralesional Glucantime.

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Serum and Hair Levels of Zinc and Other Elements in Dogs with Visceral Leishmaniasis

Cited by 18 publications

References 20 publications

Serum Zinc, Iron and Copper Concentrations in Dogs Infected with Hepatozoon canis

Serum Zinc, Iron and Copper Concentrations in Dogs Infected with Hepatozoon canis

A potential link among antioxidant enzymes, histopathology and trace elements in canine visceral leishmaniasis

Comparison of intralesional two percent zinc sulfate and glucantime injection in treatment of acute cutaneous leishmaniasis

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