Serum and hepatic lipid levels in rats infected with Trypanosoma brucei

Igbokwe, I.O.; Buratai, L. B.; Ubah, U. L.; Aromnde, A.; Igbokwe, Nanacha Afifi

doi:10.1007/s00580-008-0765-8

Cited by 7 publications

(5 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is a common finding in trypanosomosis, and is reported due to excessive utilization of blood glucose by the parasites for their metabolism (Anosa, 1988;Cadioli et al, 2006) and hepatocyte degeneration (Von Brand, 1973). Hypertriglyceridemia was reported in experimentally infected rats with T. brucei (Igbokwe et al, 2009). Rabbits infected with T. brucei developed hypertriglyceridemia and increase VLDL levels.…”

Section: Discussionmentioning

confidence: 97%

Effect of the treatment with Achyrocline satureioides (free and nanocapsules essential oil) and diminazene aceturate on hematological and biochemical parameters in rats infected by Trypanosoma evansi

Carmo

Baldissera

Vaucher

et al. 2015

Experimental Parasitology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 97%

Effect of the treatment with Achyrocline satureioides (free and nanocapsules essential oil) and diminazene aceturate on hematological and biochemical parameters in rats infected by Trypanosoma evansi

Carmo

Baldissera

Vaucher

et al. 2015

Experimental Parasitology

View full text Add to dashboard Cite

“…Igbokwe et al . (2009) also reported higher serum HDL cholesterol in male rats (46.35 mg dL −1 ) as compared to female rats (45.20 mg dL −1 ) while decreasing the level of hepatic content. The lipid level was reduced in treated animal due to presence of alkaloids, glycoside, and flavonoids components in prepared herbal formulation (Kumar et al ., 2023).…”

Section: Discussionmentioning

confidence: 87%

“…Results are well in accordance with different findings suggesting that male rats showed significant (P < 0.05) increase in serum cholesterol level (15.83 mg dL À1 ), serum triglycerides level (82.70 mg dL À1 ), serum HDL cholesterol level (50.28 mg dL À1 ), and serum HDL cholesterol level (16.54 mg dL À1 ) as compared to female rats (118.30, 78.15, 58.20, 43.33, and 11.64 mg dL À1 respectively) by intake of herbal extract such as Phyllantus niruri, Achyranthes aspera Linn, Platycodon grandiflorum, and Panax ginseng (Drexel, 2006;Barter et al, 2007;Ihedioha et al, 2013;Singh et al, 2016). Igbokwe et al (2009) also reported higher serum HDL cholesterol in male rats (46.35 mg dL À1 ) as compared to female rats (45.20 mg dL À1 ) while decreasing the level of hepatic content. The lipid level was reduced in treated animal due to presence of alkaloids, glycoside, and flavonoids components in prepared herbal formulation (Kumar et al, 2023).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the acute basic biological effects of herbal formulation to control obesity: a preliminary study

Kumar,

Kaushik,

Kaushik

et al. 2023

Int J of Food Sci Tech

View full text Add to dashboard Cite

SummaryObjectivesObesity is the accumulation of excessive visceral and subcutaneous fat in the body. The herbal formulation can help treat obesity and our study aims to evaluate the acute basic biological effects of herbal formulation to control obesity.MethodsAntiobesity herbal formulation, prepared by the combination of Saussurea lappa root, Betula utilis bark, Aconitum heterophyllum root, Bunium periscum seed, and Bauhinia variegate leaf (4:3:1:1:1), was carried out on Wistar male and female rats. Obesity was induced in the rats by feeding the Chow diet, and the effect of herbal formulation on obesity was studied. The effect on obesity was measured by analyzing variables like weight, water intake, pellet count, hematological parameters, renal function test, liver function test, and lipid profile test.ResultsIn the study, it was observed that the female rats treated at the highest dose showed a significantly (p<0.005) higher decrease in weight compared to male rats after ten days. Thefood intake, hemoglobin, renal, liver function and lipid profile showed significant improvement after the intake of herbal formulation.ConclusionsFrom the above results, it was inferred that herbal formulation increased the activity of metabolism, which is helpful in weight reduction; moreover, it has some beneficial biological effects.

show abstract

“…Impaired synthesis of cholesterol in the liver could also be the result of insufficient hepatocellular respiration due to hypoxia, reproductive endocrine disorders that could impair the reproductive performance of the trypanosome-infected animals (Adamu et al, 2008). Igbokwe et al (2008) observed serum and hepatic lipid levels in rats infected with T. brucei and found that the total serum cholesterol, HDL, and LDL cholesterol concentrations decreased (P <0.0.05) when compared to the control values on days 7 and 11 p.i.…”

Section: Cholesterolmentioning

confidence: 97%

Haemato-Clinical Changes in Pregnant and Non-Pregnant Rats, Rattus rattus Linnaeus, 1758 under Parasitic Stress

2013

Egyptian Journal of Veterinary Sciences

View full text Add to dashboard Cite

ERUM chemistry of non-pregnant (Group I) and pregnant (Group …. II) female Rattus rattus (n=389) collected alive from wild conditions in rat traps was investigated in different weight groups (A: 50-100gm, B: 100-150gm and C: 150-200gm) under uninfected and infected (Trypanosoma and Cysticercus) conditions. Groups I and II were further subdivided into four subgroups each, a: Uninfected rats, b: T. lewisi infected rats, c: C. fasciolaris-infected rats, d: T. lewisi and C. fasciolaris-infected rats. A significant maximum fall of 38.01% in glucose was recorded in pregnant rats of Group IIb (weight category B). Changes in cholesterol were insignificant in most of the groups except Group IIc (weight category B) where the fall was maximum (25.32%). Total serum protein (TSP) changes were again insignificant in most of the groups except in weight categories B of Group IIb showing 18.54% rise and Group IIc showing 22.62% fall. Changes were significant (P<0.05) in hemoglobin in parasitized rats showing a maximum fall of 36.63% in Group IIb (weight category B). The results infer that glucose and hemoglobin are the most vulnerable biochemical constituents to parasitism and that older (weight category B and C) pregnant rats (Group II) and rats with dual infection (Group IId) exhibit greater changes in their biochemical constituents.

show abstract

Serum and hepatic lipid levels in rats infected with Trypanosoma brucei

Cited by 7 publications

References 24 publications

Effect of the treatment with Achyrocline satureioides (free and nanocapsules essential oil) and diminazene aceturate on hematological and biochemical parameters in rats infected by Trypanosoma evansi

Effect of the treatment with Achyrocline satureioides (free and nanocapsules essential oil) and diminazene aceturate on hematological and biochemical parameters in rats infected by Trypanosoma evansi

Evaluation of the acute basic biological effects of herbal formulation to control obesity: a preliminary study

Haemato-Clinical Changes in Pregnant and Non-Pregnant Rats, Rattus rattus Linnaeus, 1758 under Parasitic Stress

Contact Info

Product

Resources

About