Serum and liver concentrations of tumor necrosis factor α and interleukin-1β following administration of carbon tetrachloride to male rats

Protective Effect of Cornuside against Carbon Tetrachloride-Induced Acute Hepatic Injury

“…activates Kupffer cells to release TNF-. 17) In the present study, hepatic expression of TNFincreased abnormally in the CCl 4 -treated animals. Cornuside pretreatment inhibited elevated TNF-production following CCl 4 injection, and the low level of TNF-might have played a protective role by inducing hepatocyte proliferation and the release of mediators involved in tissue repair.…”

Sparassis crispaAttenuates Carbon Tetrachloride-Induced Hepatic Injury in Rats

“…An increase in the TNF-α level has been directly correlated with the histological evidence of hepatic necrosis and the elevation in the serum aminotransferase levels [15]. DeCicco et al have reported the stimulation of TNF-α production in both serum and liver following CCl 4 administration, and it is suggested that CCl 3 • activates Kupffer cells to release TNF-α [16]. In this study, the hepatic expression of TNF-α increased abnormally in CCl 4 -administered animals.…”

Preventive effect of neutropenia on carbon tetrachloride-induced hepatotoxicity in rats

“…Inflammatory processes in which Kupffer cells, i.e. the resident macrophages of the liver, cytokines such as tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1), interleukin-6 (IL-6) and interleukin-10, and adhesion molecules such as intercellular adhesion molecule-1 are implicated in the development of CCl 4 -induced acute hepatic injury (Czaja et al, 1989(Czaja et al, , 1995ArmendarizBorunda et al, 1991;Edwards et al, 1993;Tower et al, 1994;DeCicco et al, 1998;Louis et al, 1998;Neubauer et al, 1998;Muriel et al, 2001;Simeonova et al, 2001;Hojo et al, 2002;Nakamoto et al, 2003). It is known that neutrophils, i.e.…”