Serum and Plasma in Treatment of Haemorrhage in Experimental Animals

Magladery, J. W.; Solandt, D. Y.; Best, C. H.

doi:10.1136/bmj.2.4155.248

Cited by 14 publications

(2 citation statements)

References 5 publications

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“…While the clinical effects of serum and plasma transfusions are probably similar (Magladery et al, 1940) there are certain advantages in collecting serum rather than plasma. Serum will dry somewhat more easily than plasma owing to the absence of fibrin, sodium citrate, sodiurh chloride (and possibly glucose).…”

Section: Concentration and Drying Of Plasma By The Cellophanementioning

confidence: 99%

The Concentration and Drying of Plasma

Aylward¹,

Mainwaring²,

Wilkinson³

1940

BMJ

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On the other hand, we must offset against the above advantages the difficulties and expense of the drying process, the relative stability of ordinary liquid plasmna, and, the fact that in many centres there will be a sufficiently rapid turnover of plasma in the bank to discount the necessity for storage for more than a few weeks. (Schmidt, 1938). Even a small amount of denaturation renders plasma unsuitable for clinical use, anid therefore it is impossible to place too much stress on the necessity for adequate temperature control of the dryinig process.2. Solibility. The dried product must dissolve readily and completely in sterile distilled water. The speed of solution appears to be related to some extent to the temperature of the final drying process: plasma dried from the frozen state usually yields a bulky porous powder which is readily soluble in water.3. Sterility-.-The dried plasma powder must be sterile. The above conditions are necessary whatever the scalle of the process, but when large volumes have to be, dried certain other factors also assume importance. The plasma should be diied as rapidly as possible, with the minimum of labour and attention and the minimuLm capital otutlay and running expenses.In the method of drying developed by Flosdorf and Mudd (1935) for the production of lyophil seruLIm the serum is frozen in ampoules and the water is disWilled off under high vacutLm into a vessel cooled in solid 4165

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Section: Concentration and Drying Of Plasma By The Cellophanementioning

confidence: 99%

The Concentration and Drying of Plasma

Aylward¹,

Mainwaring²,

Wilkinson³

1940

BMJ

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show abstract

“…A different point of view is that of Magladery, Solandt, and Best (1940), who state dogmatically that "there is no need to differentiate between serum and plasma. In theory and in our experience they are therapeutically identical."…”

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confidence: 99%