Serum and Tissue Granulysin as a Possible Key Markers to Detect the Severity of Psoriasis

Abstract

Background: Psoriasis is a chronic immune-mediated inflammatory skin disease, it is a disorder of both the innate and adaptive immune system. However, new updates are still emerging in its pathogenesis. Psoriasis is characterized by overexpression of antimicrobial peptides. Granulysin (GNLY) is an antimicrobial peptide that may have a role in psoriasis pathogenesis. Objective: To detect the level of serum and tissue (GNLY) in psoriatic patients and correlate it with psoriasis severity. Patients and Methods: The study was performed on 50 individuals, including 2 groups. The first group included 30 psoriasis vulgaris patients and the second group included 20 age and sex matched apparently healthy control individuals. Serum GNLY was determined in all individuals and tissue GNLY was determined in the skin of 8 patients (from lesional and perilesional skin) and 8 controls. Results: serum GNLY was slightly higher in patients group compared to control group with no statistically significant difference while, the level of tissue GNLY of lesional and perilesional skin in psoriatic patients, was significantly higher when compared to control group. Conclusion: In conclusion, granulysin is supposed to play a role in psoriasis pathogenesis and it is positively correlated with psoriasis severity