Serum and Urinary Selenium Status in Patients with the Pre-diabetes and Diabetes in Northeast China

Abstract

Homeostasis imbalance of selenium (Se) in diabetes has received great attention. This study investigated serum and urinary Se levels in patients with impaired fasting glucose (IFG), impaired glucose tolerance (IGT), type 1 diabetes (T1D), and type 2 diabetes (T2D) in Northeast Chinese populations. From January 2010 to October 2011, patients with IFG ( n = 12), IGT ( n = 15), T1D ( n = 25), T2D ( n = 137), and healthy controls ( n = 50) were enrolled in the First Hospital of Jilin University. Se was detected using inductively coupled plasma spectrometer. The serum Se level was dramatically lower in patients with T1D and was significantly higher in IFG subjects, and the urinary Se concentration was markedly lower in IGT and T2D groups. The serum Se levels were positively correlated with serum zinc (Zn) in both IFG and IGT groups, while urinary Se were positively associated with urinary Zn and copper (Cu) in IGT group. The serum Se levels were positively correlated with serum Cu in both T1D and T2D groups, and urinary levels of Se were positively associated with serum zinc and urinary Cu, Zn, calcium (Ca), and magnesium (Mg) and negatively correlated with serum Ca and Mg in T2D group, while the urinary levels of Se were positively correlated with urinary Zn and Mg both in peripheral neuropathy (DPN) and retinopathy (DR) groups. One month of simvastatin therapy reduced serum Se levels. These results suggest the potential role of Se in diabetes should receive attention.

Association between magnesium concentrations and prediabetes: a systematic review and meta-analysis

“…By examining the remaining 12 full-text articles, we exclude one study because it assessed the magnesium levels in red blood cell (RBC) 33 . In addition, one similar data was published twice 18 , 34 and we included the article that report data in detail and extractable form 18 . Eventually, ten observational studies met our eligibility criteria and include in final analysis (Fig.…”

“…Eventually, ten observational studies met our eligibility criteria and include in final analysis (Fig. 1 and Supplementary Table 1 ) 18 – 22 , 35 – 39 .

Figure 1 PRISMA flowchart describing the study’s systematic literature search and study selection.

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“…Out of 10 studies, 3 studies were conducted in China 18 , 19 , 36 and others were conducted in the United states 21 , Netherlands 37 , Sweden 20 , Bangladesh 22 , India 39 , Italy 38 and Turkey 35 . Two studies assessed magnesium level by inductively coupled plasma spectrometry 18 , 19 , two studies used atomic absorption 20 , 36 and in other studies other methods were used. Six studies used cross-sectional design 20 , 21 , 35 , 37 – 39 and the rest of them applied case–control design.…”

“…Eventually, ten observational studies met our eligibility criteria and include in final analysis (Fig. 1 and Supplementary Table 1) [18][19][20][21][22][35][36][37][38][39] .…”

“…Previous studies that investigated the associations between the circulating levels of magnesium and prediabetes have yielded inconsistent results. Some studies documented the lower levels of magnesium in people with prediabetes compared to their healthy controls [18][19][20] , while others did not find significant differences 21,22 . Till now, there is no meta-analyses to address these inconsistent results.…”