Serum Angiopoietin-2 and CRP Levels During COPD Exacerbations

Nikolakopoulou, Sofia; Hillas, Georgios; Perrea, Despina; Tentolouris, Nikolaοs; Loukides, Stelios; Κostikas, Κonstantinos; Simoes, Davina Camargo Madeira; Georgakopoulou, Erasmia; Vogiatzakis, E.; Veldekis, Dimitrios; Bakakos, Petros

doi:10.3109/15412555.2013.829436

Cited by 13 publications

(4 citation statements)

References 29 publications

(27 reference statements)

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“…As opposed to the subjective and variable physical and physiological endpoints used to guide therapy in stable COPD, there are no reliable indicators of a patient's exacerbation status, susceptibility, or disease progression. Accordingly, there is a growing interest in the development and use of biomarkers to assess disease and predict disease progression in COPD [26][27][28][29] . Ideally, biomarkers will better reflect disease activity while representing biologically relevant pathways.…”

Section: Scientific Reports |mentioning

confidence: 99%

Unique natural killer cell subpopulations are associated with exacerbation risk in chronic obstructive pulmonary disease

Osterburg

Lach

Panos

et al. 2020

Sci Rep

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open Scientific RepoRtS | (2020) 10:1238 | https://doi.org/10.1038/s41598-020-58326-7www.nature.com/scientificreports www.nature.com/scientificreports/ cytolytic response of NK cells. Activated cells release cytokines such as interferon gamma (IFNγ) and tumor necrosis factor alpha (TNFα), among others, which recruit and activate other immune system cells. Perforin release from NK cells causes pore formation in target cell membranes; proteases such as granzyme A and B can enter the cell to induce apoptosis by caspase cleavage as well as cleave other cellular targets. Therefore, aberrant and/or chronic activation of NK cells can result in chronic inflammation and tissue damage.Given the morbidities and economic burden of COPD and AECOPD, it is important to examine the immune function of these patients in greater detail than previous studies. In this study, we utilized polychromatic flow cytometry to measure the expression of an array of activating and inhibitory receptors on peripheral blood natural killer cells from never smokers, current smokers, and COPD patients. We identified >1,000 significant and unique NK cell subpopulations using the Scalable Weighted Iterative Flow-clustering Technique (SWIFT) 6-8 . These data reveal several changes in the expression of NK cell activating/inhibitory receptors and the size of the NK cell subpopulations associated with smoking and COPD. Furthermore, we demonstrate that logistic regression analysis using population size and receptor expression from peripheral blood NK cells is highly predictive of patients with a previous exacerbation. These findings provide an entry point to more closely examine the effects of smoking on NK cell phenotype and function, the role of NK cells in COPD exacerbations, and the use of NK cells as biomarkers for exacerbations. Scientific RepoRtS |(2020) 10:1238 | https://doi.

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Section: Scientific Reports |mentioning

confidence: 99%

Unique natural killer cell subpopulations are associated with exacerbation risk in chronic obstructive pulmonary disease

Osterburg

Lach

Panos

et al. 2020

Sci Rep

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“…The levels of Ang-2 decreased after a week of treatment. Patients with poorer outcomes also had significantly higher Ang-2 levels [118]. This suggests that Ang-2 might be a useful biomarker for COPD exacerbations and might help clinicians identify patients at risk of worse outcomes at the start of an exacerbation.…”

Section: Introductionmentioning

confidence: 99%

The role of the endothelium in asthma and chronic obstructive pulmonary disease (COPD)

Green

Turner

2017

Respir Res

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COPD and asthma are important chronic inflammatory disorders with a high associated morbidity. Much research has concentrated on the role of inflammatory cells, such as the neutrophil, in these diseases, but relatively little focus has been given to the endothelial tissue, through which inflammatory cells must transmigrate to reach the lung parenchyma and cause damage. There is evidence that there is an abnormal amount of endothelial tissue in COPD and asthma and that this tissue and its’ progenitor cells behave in a dysfunctional manner. This article reviews the evidence of the involvement of pulmonary endothelium in COPD and asthma and potential treatment options for this.

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“…CRP levels were found to be elevated among the smokers than the non-smokers. A similar study showed a decrease in serum CRP levels based on a week of hospitalization in COPD patients [ 50 ].…”

Section: Discussionmentioning

confidence: 91%

Evaluation of Salivary Biomarkers and Spirometry for Diagnosing COPD in Non-Smokers and Smokers of Polish Origin

Rudzinska-Radecka,

Bańcerowski,

Marczyński

et al. 2024

Biomedicines

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Chronic obstructive pulmonary disease (COPD) is a prevalent respiratory condition with global implications. Accurate and timely diagnosis is critical; however, traditional diagnostic methods (based on spirometry) show limitations, prompting the search for predictive biomarkers and modern diagnostic techniques. This study explored the validation of COPD-related biomarkers (C-reactive protein, procalcitonin, neutrophil elastase, and alpha-1 antitrypsin) in saliva. A diverse cohort, including healthy non-smokers, healthy smokers, and COPD patients of Polish origin, underwent spirometry and marker analysis. The data correlated with clinical factors, revealing noteworthy relations. Firstly, salivary biomarker levels were compared with serum concentrations, demonstrating notable positive or negative correlations, depending on the factor. Further analysis within healthy individuals revealed associations between biomarker levels, spirometry, and clinical characteristics such as age, sex, and BMI. Next, COPD patients exhibited an enhanced concentration of biomarkers compared to healthy groups. Finally, the study introduced a breathing assessment survey, unveiling significant associations between self-perceived breathing and spirometric and tested parameters. Outcomes emphasized the relevance of subjective experiences in COPD research. In conclusion, this research underscored the potential of salivary biomarkers as diagnostic tools for COPD, offering a non-invasive and accessible alternative to traditional methods. The findings paved the way for improved modern diagnostic approaches.

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Serum Angiopoietin-2 and CRP Levels During COPD Exacerbations

Cited by 13 publications

References 29 publications

Unique natural killer cell subpopulations are associated with exacerbation risk in chronic obstructive pulmonary disease

Unique natural killer cell subpopulations are associated with exacerbation risk in chronic obstructive pulmonary disease

The role of the endothelium in asthma and chronic obstructive pulmonary disease (COPD)

Evaluation of Salivary Biomarkers and Spirometry for Diagnosing COPD in Non-Smokers and Smokers of Polish Origin

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